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Pharmacological activities of Andrographis paniculata, Allium sativum and Adhatoda vasica

Review Paper | March 1, 2013

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Manoharan Sivananthan

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Int. J. Biomol. & Biomed.3( 2), 13-20, March 2013


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Andrographis paniculata, Allium sativum and Adhatoda vasica are the three important medicinal plants in which it is used for daily consumption by the user especially in the rural areas. Not only rural people are seeking for the medical benefits from the medicinal plants but also urban people because trying to eliminate the side effects of synthetic medicine on health. Research using these three plants should not stop here and must be extensively employed by the researchers and try to get more medical properties which is useful for the public. Andrographolide from Andrographis paniculata is the active component obtained from the aerial parts of this plant, having very bitter taste. It is a bicyclic diterpenoid lactone with multiple pharmacological activities. In 1997, garlic (Allium sativum) was the most widely used natural supplement in US house-holds. Garlic was shown to be used more than twice as much as any other natural supplement. Extract of Adhatoda vasica leaves has been used for the treatment of various diseases and disorders in Ayurved and Unani medicine. The plant has been used in the indigenous system of medicine in India for more than 2000 years. Compounds which are present in the plant/s which when consumed it promote the health of the consumers although some studies suggest that consumption may lead to toxic effect but in general it is safe to consume moderately. In many literature survey, researchers are trying the best to overcome the bacterial resistance by isolating compounds from the medicinal plants (one of the method) due to the resistance of bacterias towards synthetic chemicals. Overally this proved the importance of the medicinal plants.


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Pharmacological activities of Andrographis paniculata, Allium sativum and Adhatoda vasica

Alireza V, Mihdzar AK, Soon GT, Daryush T, Mohd PA, Sonia N. 2011. Nain-e Havandi Andrographis paniculata present yesterday, absent today: a plenary review on underutilized herb of Iran’s pharmaceutical plants. An International Journal on Molecular and Cellular Biology 39(5), 5409- 5424.

Bathaei FS, Akhondzadeh S. 2008. Cardiovascular Effects of Allium Sativum (Garlic): An Evidence-Based Review, Journal of Tehran University Heart Center 1, 5- 10.

Bhandari PR, 2012. Garlic ( allium sativum L): A review of potential therapeutic applications. International journal green pharmacy 6, 118- 129.

Bhattacharya S, Puri S, Jamwal A, Sharma S. 2012. Studies on seed germination and seedling growth in kalmegh ( Andrographis paniculata wall. Ex Nees) under abiotic stress condition. International Journal of Science, Environment and Technology 1(3), 197– 204.

Bongiorno  PB,  Fratellone  PM,  LoGiudice  P. 2008. Potential Health Benefits of Garlic (Allium Sativum): A Narrative Review. Journal of Complementary and Integrative Medicine 5(1), 1- 24, http://dx.doi.org/10.2202/1553-3840.1084

Chiramel T, Bagyaraj DJ, Patil CSP. 2006. Response of Andrographis paniculata to different arbuscular mycorrhizal fungi. Journal of Agricultural Technology 2(2), 221- 228.

Dandin VS, Murthy HN. 2012. Regeneration of Andrographis paniculata Nees: Analysis of genetic fidelity and andrographolide content in micropropagated plant. African Journal of Biotechnology 11(61), 12464- 12471, http://dx.doi.org/10.5897/AJB12.1551

Doro AK. 2012. Effect of irrigation interval on the yield of garlic (Allium sativum L.) at ajiwa irrigation site of Katsina state- Nigeria. Jorind 10(2), 30- 33.

Hernawan UE, Setyawan AD. 2003, Review: Senyawa Organosulfur Bawang Putih (Allium sativum L.) dan Aktivitas Biologinya. Biofarmasi 1(2), 65- 76.

Jadhao M. Estimation of andrographolide in herbal powder and polyherbal asava by HPTLC. International Journal of Pharma and Bio Sciences 1(4), 242- 245.

Jegathambigai R, Devaraj S, Kumar P, Sivaramakrishnan S. 2010. A Study on the hepatoprotective effect of Andrographis paniculata (Burm. F) nees on mice. Journal of Phytology 2(11), 25- 30.

Kumar KPS, Bhowmik D, Chiranjib, Tiwari P, Kharel R. 2010. Indian traditional herbs Adhatoda vasica and its Medicinal application. Journal of Chemical and Pharmacy Research 2(1), 240- 245.

Kunwar RM, Shrestha KP, Bussmann RW. 2010. Traditional herbal medicine in Far-west Nepal: A pharmacological appraisal. Journal of Ethnobiology and Ethnomedicine 6, 35, http://dx.doi.org/10.1186/1746-4269-6-35

Maiti K, Gantait A, Mukherjee K, Saha BP, Mukherjee PK. 2006. Therapeutic potentials of Andrographolide from Andrographis paniculata : A review. Journal of Natural Remedies 6(1), 1 – 13.

Martin KP. 2004. Plant regeneration protocol of medicinally important Andrographis paniculata (Burm. F) Ex nees via somatic embryogenesis. In Vitro Cell Devision Biology of Plant 40, 204- 209, http://dx.doi.org/10.1079/IVP2003520

Rachana, Sujata B, Mamta P, Priyanka KJ, Sonam S. 2011. Review and Future Perspectives of Using Vasicine, and Related Compounds. Indo-Global Journal of Pharmaceutical Sciences 1(1), 85- 98.

Rajpar I, Khanif YM, Hassan ZU, Shah AN, Arshad M, Galani S. 2011. Growth, herb yield and phytochemical contents in a medicinal herb Andrographis paniculata under saline Irrigation. Journal of Medicinal Plants Research 5(23), 5528-5533.

Ranjani R, Raju MA. 2012. Anticancer Properties of Allium sativum- A Review. Asian Journal of Biochemical and Pharmaceutical Research 3(2), 190-196.

Singh TP, Singh OM, Singh HB. 2011. Adhatoda vasica Nees: Phytochemical and Pharmacological Profile. The Natural Products Journal 1, 29- 39.

Sivananthan M, Elamaran M. 2013. In vitro evaluation of antibacterial activity of chloroform extract Andrographis paniculata leaves and roots, Durio zibethinus wood bark and Psidium guajava leaves against selected bacterial strains. International Journal of Biomolecule and Biomedicine 3(1), 12- 19.

Soni S, Anandjiwala S, Patel G, Rajani M. 2008. Validation of Different Methods of Preparation of Adhatoda vasica Leaf Juice by Quantification of Total Alkaloids and Vasicine. Indian Journal of Pharmaceutical Science 70(1), 36-42 http://dx.doi.org/10.4103/0250-474X.40329

Sudhakaran MV. 2012. Botanical pharmacognosy of Andrographis paniculata (burm. f). wall. Ex. Nees. Pharmacognosy journal 4(32), 1-10, http://dx.doi.org/10.5530/pj.2012.32.1

Talei D, Kadir MA, Yusop MK, Valdiani A, Abdullah MP. 2013. Growth indices and salinity tolerance threshold in a medicinal plant Andrographis paniculata Nees. Journal of Medicinal Plants Research 7(3), 104- 110.

Yadav AK, Tangpu V. 2008. Anticestodal activity of Adhatoda vasica extract against Hymenolepis diminuta infections in rats. Journal of Ethnopharmacology 119, 322– 324, http://dx.doi.org/10.1016/j.jep.2008.07.012