Philippine ethnobotanicals show anti-proliferative and cytotoxic activities in human breast cancer cells (MCF-7)

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Research Paper 01/11/2018
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Philippine ethnobotanicals show anti-proliferative and cytotoxic activities in human breast cancer cells (MCF-7)

Edlyn E. Pooten, Glenn G. Oyong, Khristina G. Judan Cruz
Int. J. Biosci.13( 5), 239-251, November 2018.
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Abstract

The increasing trend and threat of breast cancer had paved the search for novel compounds to discover drugs for its treatment.  Since the discovery and development of plant-based anti-tumor drugs, plants has been the focus of several researches to discover species with pharmacological potential. The Philippine Ilongot-Egongot ethno botanicals were tested for anti-proliferative and cytotoxic activities to determine their anticancer potential against breast adenocarcinoma (MCF-7) cancer cell line using PrestoBlue® Assay.  Nine extracts showed toxic effects on MCF-7 cells: Cestrum nocturnum, Sarcandra glabra, Oreocnide trinervis, Pittosporum pentandrum, Derris elliptica, Alstonia scholaris, Ageratina adenophora, Ayapana triplinervis and Lop-lopiit (no known scientific name), Two extracts showed anticancer activity against MCF-7 while being nontoxic to the normal cells (normal primary dermal fibroblast, neonatal (HDFn):  O. trinervis and A. triplinervis.  This preferential toxicity makes these enthnobotanicals ideal candidates for anti-cancer drug discovery and development.

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