Physiochemical extraction, spectroanalytical identification, antibacterial and docking studies of four new source phytochemicals from the bark of Millettia ovalifolia

Paper Details

Research Paper 01/07/2017
Views (566)
current_issue_feature_image
publication_file

Physiochemical extraction, spectroanalytical identification, antibacterial and docking studies of four new source phytochemicals from the bark of Millettia ovalifolia

Taj Ur Rahman, Muhammad Aurang Zeb, Sajjad Hussain, Wajiha Liaqat
Int. J. Biosci. 11(1), 222-231, July 2017.
Copyright Statement: Copyright 2017; The Author(s).
License: CC BY-NC 4.0

Abstract

The Spectroanalytical analysis and physiochemical extraction of bark of Millettia ovalifolia yielded phytochemicals, which included four new source compounds comprising of flavonoid characterized as 3,7-Dihydroxy-2-phenyl-4H-chromen-4-one, cinnamic acids, characterized as (E)-Ethyl 13-(3,4-dimethoxyphenyl) acrylate, (E)-Methyl 3-(3,4-dimethoxyphenyl) acrylate and N-Ethylacetamide. These isolated compounds were characterized by using advance modern Spectro analytical techniques such as UV, IR, 1D, 2D NMR and mass spectrometry. The isolated compounds were further studies for their antibacterial potency and docking studies.

Ali SI. Flora of Pakistan: Shamim Printing Press: Karachi, 1977 100, 51-52.

Carron Ra, Maran JM, Montero L, Fernandozaigo L, Dominguez AA. 1987. Pl. Med. Phytother 21, 195-202.

Fuendjiep V, Nkengfack AE, Fomum ZT, Sondengam BL, Bodo B. 1998. Conrauinones C and D, two isoflavones from stem bark of Millettia conraui. Phytochemistry 47(1), pp.113-115.

Jakupovic J. 2003. New caffeic acid esters from Plazia daphnoides. Zeitschrift für Naturforschung C 58(1-2), pp.39-41.

Ito C, Itoigawa M, Tan HT, Tokuda H, Mou XY, Mukainaka T, Ishikawa T, Nishino H, Furukawa H. 2000. Anti-tumor-promoting effects of isoflavonoids on Epstein–Barr virus activation and two-stage mouse skin carcinogenesis. Cancer letters 152(2), pp.187-192.

Katsuhiko ONO, NAKANE H, Zeng-Mu MENG, Youki OSE, SAKAI Y, MIZUNO M, 1989. Differential inhibitory effects of various herb extracts on the activities of reverse transcriptase and various deoxyribonucleic acid (DNA) polymerases. Chemical and Pharmaceutical Bulletin 37(7), pp.1810-1812.

Ngamga D, Free SF, Tane P, Fomum ZT. 2007. Millaurine A, a new guanidine alkaloid from seeds of Millettia laurentii. Fitoterapia 78(3), pp.276-277.

Palazzino G, Rasoanaivo P, Federici E, Nicoletti M, Galeffi C. 2003. Prenylated isoflavonoids from Millettia pervilleana.  Phytochemistry 63(4), pp.471-474.

Shafaghat A, Salimi FARSHID. 2008. Extraction and determining of chemical structure of flavonoids in Tanacetum parthenium (L.) Schultz. Bip. from Iran. Journal of Sciences Islamic Azad University 18(68), pp.39-42.

Wolfrom ML, Benton FL, Gregory AS, Hess WW, Mahan JE, Morgan PW. 1939. Osage orange pigments. II. Isolation of a new pigment, pomiferin. Journal of the American Chemical Society 61(10), pp.2832-2836.

Yankep E, Mbafor JT, Fomum ZT, Steinbeck C, Messanga BB, Nyasse B, Budzikiewicz H, Lenz C, Schmickler H. 2001. Further isoflavonoid metabolites from Millettia griffoniana (Bail). Phytochemistry 56(4), pp.363-368.

Yenesew A, Derese S, Midiwo JO, Heydenreich M, Peter MG. 2003. Effect of rotenoids from the seeds of Millettia dura on larvae of Aedes aegypti. Pest management science 59(10), pp.1159-1161.

Yenesew A, Derese S, Midiwo JO, Oketch-Rabah HA, Lisgarten J, Palmer R, Heydenreich M, Peter MG, Akala H, Wangui J, Liyala P. 2003. Anti-plasmodial activities and X-ray crystal structures of rotenoids from Millettia usaramensis subspecies usaramensis. Phytochemistry 64(3), pp.773-779.

Related Articles

Flammability of tropical grasses: Towards a functional ecology of fire in savannas

Kouamé Fulgence Koffi, Yao Anicet Gervais Kouamé, Tionhonkélé Drissa Soro, Koffi Prosper Kpangba, Int. J. Biosci. 27(4), 57-68, October 2025.

Sensory qualities, proximate composition and microbial activity of cacao pod-based food products

John Carlo L. Banan, Aiza T. Ramos, Int. J. Biosci. 27(4), 48-56, October 2025.

Perception of oil palm producers on infestations of Trabanta rufisquamata defoliating caterpillars in palm groves in southern Benin

Abilou Oloyiwola Olorounto, Hervé Nonwegnon Sayimi Aholoukpe, Micheline Vignon Hintenou, Houngan Judicaël Yelian Yan, Ladekpo Sylvain Ogoudjobi, Antoine Badou, Aimé H. Bokonon-Ganta, Int. J. Biosci. 27(4), 34-47, October 2025.

Fire spread control for management purpose: Fuel moisture critical threshold in annually burned dry savanna of west Africa

Tionhonkélé Drissa Soro, Jean-Luc Kouassi, Bareremna Afelu, Amara Ouattara, Moussa Koné, Int. J. Biosci. 27(4), 19-33, October 2025.

Renal protection by Okra (Abelmoschus esculentus) seed oil against cadmium toxicity in male rats

Amani A. R. Filimban, Nada O. Batais, Int. J. Biosci. 27(4), 8-18, October 2025.

Effects of an organic amendment based on biodigester effluent on cotton yield parameters in the Cascades region of Burkina Faso

F. Y. Lankoande, A. Bamogo, M. Traore, S. Ouedraogo, Int. J. Biosci. 27(4), 1-7, October 2025.

Organic feed additive Alpha-Bio+ as an alternative to chemical antibiotics: Effect on zootechnical performance and coccidial burden in laying hens Lohmann Brown

Coulibaly Assetou Ya, Yapi Jean Noel, Kadjo Vincent, Ouattara N’Golo , Yao Kouakou, Int. J. Biosci. 27(3), 221-228, September 2025.

Effects of different postharvest treatments on the physicochemical properties and shelf life of fresh-cut Mango and Guava

Rashiduzzaman Emran, , Md. Mejbah Uddin, Md. Mahmudul Hasan Manik, Md. Nuruddin Miah, Int. J. Biosci. 27(3), 210-220, September 2025.