Physiochemical extraction, spectroanalytical identification, antibacterial and docking studies of four new source phytochemicals from the bark of Millettia ovalifolia

Paper Details

Research Paper 01/07/2017
Views (586)
current_issue_feature_image
publication_file

Physiochemical extraction, spectroanalytical identification, antibacterial and docking studies of four new source phytochemicals from the bark of Millettia ovalifolia

Taj Ur Rahman, Muhammad Aurang Zeb, Sajjad Hussain, Wajiha Liaqat
Int. J. Biosci. 11(1), 222-231, July 2017.
Copyright Statement: Copyright 2017; The Author(s).
License: CC BY-NC 4.0

Abstract

The Spectroanalytical analysis and physiochemical extraction of bark of Millettia ovalifolia yielded phytochemicals, which included four new source compounds comprising of flavonoid characterized as 3,7-Dihydroxy-2-phenyl-4H-chromen-4-one, cinnamic acids, characterized as (E)-Ethyl 13-(3,4-dimethoxyphenyl) acrylate, (E)-Methyl 3-(3,4-dimethoxyphenyl) acrylate and N-Ethylacetamide. These isolated compounds were characterized by using advance modern Spectro analytical techniques such as UV, IR, 1D, 2D NMR and mass spectrometry. The isolated compounds were further studies for their antibacterial potency and docking studies.

Ali SI. Flora of Pakistan: Shamim Printing Press: Karachi, 1977 100, 51-52.

Carron Ra, Maran JM, Montero L, Fernandozaigo L, Dominguez AA. 1987. Pl. Med. Phytother 21, 195-202.

Fuendjiep V, Nkengfack AE, Fomum ZT, Sondengam BL, Bodo B. 1998. Conrauinones C and D, two isoflavones from stem bark of Millettia conraui. Phytochemistry 47(1), pp.113-115.

Jakupovic J. 2003. New caffeic acid esters from Plazia daphnoides. Zeitschrift für Naturforschung C 58(1-2), pp.39-41.

Ito C, Itoigawa M, Tan HT, Tokuda H, Mou XY, Mukainaka T, Ishikawa T, Nishino H, Furukawa H. 2000. Anti-tumor-promoting effects of isoflavonoids on Epstein–Barr virus activation and two-stage mouse skin carcinogenesis. Cancer letters 152(2), pp.187-192.

Katsuhiko ONO, NAKANE H, Zeng-Mu MENG, Youki OSE, SAKAI Y, MIZUNO M, 1989. Differential inhibitory effects of various herb extracts on the activities of reverse transcriptase and various deoxyribonucleic acid (DNA) polymerases. Chemical and Pharmaceutical Bulletin 37(7), pp.1810-1812.

Ngamga D, Free SF, Tane P, Fomum ZT. 2007. Millaurine A, a new guanidine alkaloid from seeds of Millettia laurentii. Fitoterapia 78(3), pp.276-277.

Palazzino G, Rasoanaivo P, Federici E, Nicoletti M, Galeffi C. 2003. Prenylated isoflavonoids from Millettia pervilleana.  Phytochemistry 63(4), pp.471-474.

Shafaghat A, Salimi FARSHID. 2008. Extraction and determining of chemical structure of flavonoids in Tanacetum parthenium (L.) Schultz. Bip. from Iran. Journal of Sciences Islamic Azad University 18(68), pp.39-42.

Wolfrom ML, Benton FL, Gregory AS, Hess WW, Mahan JE, Morgan PW. 1939. Osage orange pigments. II. Isolation of a new pigment, pomiferin. Journal of the American Chemical Society 61(10), pp.2832-2836.

Yankep E, Mbafor JT, Fomum ZT, Steinbeck C, Messanga BB, Nyasse B, Budzikiewicz H, Lenz C, Schmickler H. 2001. Further isoflavonoid metabolites from Millettia griffoniana (Bail). Phytochemistry 56(4), pp.363-368.

Yenesew A, Derese S, Midiwo JO, Heydenreich M, Peter MG. 2003. Effect of rotenoids from the seeds of Millettia dura on larvae of Aedes aegypti. Pest management science 59(10), pp.1159-1161.

Yenesew A, Derese S, Midiwo JO, Oketch-Rabah HA, Lisgarten J, Palmer R, Heydenreich M, Peter MG, Akala H, Wangui J, Liyala P. 2003. Anti-plasmodial activities and X-ray crystal structures of rotenoids from Millettia usaramensis subspecies usaramensis. Phytochemistry 64(3), pp.773-779.

Related Articles

Modelling the current and future distribution of Okoubaka aubrevillei Pellegr. & Normand under climate change scenarios in Côte d’Ivoire

Sié Fernand Pacôme Ouattara, Franck Placide Junior Pagny, Kouassi Bruno Kpangui, Int. J. Biosci. 27(5), 237-246, November 2025.

Proximate analysis of pelleted sorghum-based feeds as substitute for corn

I. I. Juan S. Daquioag, Michael M. Uy, Int. J. Biosci. 27(5), 232-236, November 2025.

Evolution of the weight of carcasses and offal of Cobb 500 broiler chickens according to the age of slaughter

Soro Soronikpoho, Kouadio Kouakou Parfait, Kouassi Koffi Dongo, Brou Gboko Konan Gatien, Int. J. Biosci. 27(5), 225-231, November 2025.

Agronomic performance of the newly pruned coffee trees at the CSU Lal-lo old coffee plantation

Maribel L. Fernandez, Florante Victor M. Balatico, Ronel A. Collado, Int. J. Biosci. 27(5), 217-224, November 2025.

A comprehensive review and meta-analysis on Alzheimer’s genetics: Exploring the genetic architecture and its application in future genomic medicine

Shafee Ur Rehman, Shabeer Khan, Muhammad Usman, Sakarie Khadar Ibrahim, Int. J. Biosci. 27(5), 204-216, November 2025.

Effect of aqueous leaf extract of Senna occidentalis (Fabaceae) on induced arrhythmia in Rabbits

Obrou Jean Luc Amiltone, Nagalo Ousmane, Mossoun Mossoun Arsène, Abo Kouakou Jean-Claude, Int. J. Biosci. 27(5), 198-203, November 2025.

Targeting proteolytic enzymes in the hemoglobin degradation pathway to inhibit Plasmodium falciparum: An in silico approach

Sethupathi Virumandi, Elumalai Balamurugan, Aakash Ganesan, Sowmiya Ganesan, Srinidhi Raveenthiran, Int. J. Biosci. 27(5), 182-197, November 2025.