Phytochemical and pharmacological profile of Sambucus nigra

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Review Paper 01/05/2021
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Phytochemical and pharmacological profile of Sambucus nigra

Muhammad Faizan, Farah Feroz
Int. J. Biosci. 18(5), 14-19, May 2021.
Copyright Statement: Copyright 2021; The Author(s).
License: CC BY-NC 4.0

Abstract

The plants are used to promote health and also used for the treatment of various diseases for mankind nowadays. But, the plant-based drugs which are recently identified or researched by the modern framework, are more reliable and beneficial for clinical use. The plant “Elderberry” (Sambucus nigra) is the best source to extract proteins and its extractsare being used for multi-purpose activities including treatment of cardiovascular diseases,good impact on the immune system, antitumor activity and are also used for UV rays protection, etc. A very simple and environmentally friendly method is applied for the synthesis of silver nanoparticles by using European black elderberry(Sambucus nigra).By this,the extraction of different fruits was developed.Thousands of plant species are growing worldwide which have medicinal use and contain different active constituents that have a direct effect or action on the human body. This article gives an overview of the key concepts based on the pharmacological profile of Sambucus nigra.

Abuja PM, Murkovic M, Pfannhauser W. 1998.  Antioxidant and prooxidant activities of elderberry (Sambucus nigra) extract in low-density lipoprotein oxidation. Journal ofAgricultural and Food Chemistry 46, 4091–4096.

Barnes J, Anderson LA, Phillipson JD. 2007. Herbal medicines 3, 1421-1424.

Barak V, Birkenfeld S, Halperin T, Kalickman I. 2002. The effect of herbal remedies on the production of human inflammatory and anti-inflammatory cytokines. The Israel Medical Association Journal 4, 919–922.

Bratu MM, Doroftei E, Negreanu-Pirjof T, Hostina C, Porta S. 2012. Antioxidant activity and toxicity of Sambucus nigra. Food Technology and Biotechnology 50, 177–182.

Ciocoiu M, Badescu L, Badulescu O, Tutunaru D, Badescu M. 2012. Protective intervention of Sambucus Nigra polyphenols in the diabetic heart. Annals of the RomanianSociety for Cell Biology 17, 312–317.

Casati CB, Sánchez V, Baeza R, Magnani N, Evelson P, Zamora MC. 2012.  Relationships between color parameters, phenolic content and sensory changes of processed blueberry, elderberry and blackcurrant commercial juices. International Journal of Food Science and Technology 47, 1728–1736.

Cejpek K, Maloušková I, Konecˇný M, Velíšek J. 2009.  Antioxidant activity in variously prepared elderberry foods and supplements. Czech Journal of Food Sciences 27, 45–48.

Christensen LP, Kaack K, Fretté XC. 2008.  Selection of elderberry (Sambucus nigra) genotypes best suited for the preparation of elderflower extracts rich in flavonoids and phenolic acids. European Food Research and Technology 227, 293-305.

Duymus HG, Göger F, Bas er KHC. 2014. In vitro antioxidant properties and anthocyanin compositions of elderberry extracts. Food Chemistry, 155, 112–119.

Cherniack EP. 2013. Use of complementary and alternative medicine to treat constipation in the elderly, Journal of the American Chemical Society 13, 533-538.

Gray AM, Abel-Wahab YHA, Flatt PR. 2000. The traditional plant treatment, Sambucus nigra(elder), exhibits insulin-like and insulin-releasing actions in vitro. The Journalof Nutrition, 113, 15–20.

Groza M, Jitaru D, Ba˘descu L, Ciocoiu M, Ba˘descu M. 2011. Evaluation of the immune defense in diabetes mellitus using an experimental model. Romanian Biotechnology Letters 16, 5971–5979.

Gil-Izquierdo A, Gil MI, Ferreres F, Tomas-Barberan FA. 2001. In vitro availability of flavonoids and other phenolics in orange juice. Journal of Agricultural and Food Chemistry 49, 1035–1041.

Groza M, Ciocoiu M, Badescu L, Badulescu O, Badescu M. 2010. The effects of Sambucus nigravegetal extracts on the immune system dysfunction in the diabetes mellitus. Annalsof the Romanian Society for Cell Biology 15, 241–246.

Duymus HG, Goger F, Baser KHC. 2014. In vitro antioxidant properties and anthocyanin composition of elderberry extracts, Food Chemistry 155, 112-119.

Lee J, Finn CE. 2007.  Anthocyanins and other polyphenolics in American elderberry (Sambucus Canadensis) and European elderberry (Sambucus nigra) cultivars, Journal of Agricultural and Food Chemistry 87, 2665-2675.

Jovanovic SV, Steenken S, Tosic M, Majanovic A, Simic MG. 1994. Flavonoids as antioxidants. Journal of the American Chemical Society 116, 4846–4851.

Mikulic-Petkovsek M, Slatnar A, Stampar F, Veberic R. 2012. HPLC identification and quantification of flavonol glycosides in 28 wild and cultivated berry species. Food Chemistry 135, 2138–2146.

Mittal M, Siddiqui MR, Tran K, Reddy SP, Malik AB. 2014.  Reactive oxygen species in inflammation and tissue injury. Antioxidants & Redox Signaling 20, 1126– 1167.

Negreanu-Pirjof T, Hostina C, Porta S. 2012. Antioxidant activity and toxicity of Sambucus nigra. Food Technology and Biotechnology 50, 177–182.

Olejnik A, Rychlik J, Kidon M, Czapski J, Kowalska K, Juzwa W, Olkowicz M, Dembczyn Ski R, Moyer MP. 2016.  Antioxidant effects of gastrointestinal digested purple carrot extract on the human cells of colonic mucosa. Food Chemistry 190, 1069–1077.

Podolsky DK. 2002. Inflammatory bowel disease. New England Journal of Medicine 347, 417–429.

Rice-Evans CA, Miller NJ, Paganga G. 1996. Structure antioxidant activity relationships of flavonoids and phenolic acids. Free Radical Biology and Medicine 20, 933–956.

Lim TK. 2012. In vitro availability of flavonoids and other phenolics in orange juice. Food Chemistry 3, 30-44.

Tag MS, Miller EE, Pratt DE. 1984. China seeds as a source of natural lipid antioxidants. Journal of the American Oil Chemists’ Society 61, 928–931.

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