Phytochemical and pharmacological studies on medicinally important plant Opuntia dillenii collected from Pakistan

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Research Paper 01/08/2021
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Phytochemical and pharmacological studies on medicinally important plant Opuntia dillenii collected from Pakistan

Mushtaq Ahmad, Amin ur Rahman, Humaira Inayat, Farah Gul, Yaqoob ur Rehman, Muhammad Qaisar, Jehangir Shah, Noor Rehman, Saadullah Mir, Muhammad Tariq, Muhammad Saddique Arbab, Hamid Ali
Int. J. Biosci.19( 2), 82-89, August 2021.
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Abstract

Keeping in view the numerous useful pharmacological activities of Opuntia plants, we explored in detail the secondary metabolites and metals in different parts, fatty acids composition of seed oil and a detailed anti-inflammatory study of the cladodes along with acute toxicity studies of Opuntia dillenii collected from Pakistan. Carbohydrates, saponins, tannins, flavonoids, terpenoids and phenols were present in both the cladodes and fruit part. Terpenes and sterols were found in the cladode part while alkaloids were only present in the fruit part. Highest quantity of sodium was found in the same quantity (394.00 ppm) cladodes and fruit while potassium was abundantly present in the fruit part (15430.00 ppm). Calcium was present in a very high quantity in the cladodes (11820.00 ppm) and fruit (16419.40 ppm). Linoleic acid, a potent cyclooxygenase-2 (COX-2) inhibitor, was with highest concentration (59.153 %) among fatty acids. The crude extract displayed significant anti-inflammatory activity (50.88 %) at 300 mg/kg body weight dose after 3h dose injection. Acute toxicity tests confirmed the safety of crude extract to a dose level of up to 1000 mg/kg body weight. The present study provides a base to the natural product chemists to carry out further studies on the isolation of the secondary metabolites from Opuntia dillenii and explore the bio-efficacies of the individual compounds.

VIEWS 23

Ahmad A, Davies J, Randall S. Skinner GRB. 1996. Antiviral properties of Extract of Opuntia strepta-cantha. Antiviral Research 30, 75-85. (http://dx.doi.org/10.1016/0166-3542(95)00839-X)

AOAC. 991.39, 17th ed., 2000, 26.

Bruneton J. Pharmacognosy, phytochemistry and medicinal plants, Lavoisier publishing, Paris, 1995.

Choi J, Lee CK, Lee YC, Moon YI, Park HJ, Han YN. 2002. Biological Activities of the Extracts from Fruit and Stem of Prickly Pear Opuntia ficus-indica var.saboten II-Effects on Dietary Induced Hyperlipidemia. Korean Journal of Pharmacognosy 33, 230-237.

Curry A, Beeching NJ, Gilbert JD, Scott G, Rowland PL, Currie BJ. 2005. Trachipleistophora hominis Infection in the Myocardium and Skeletal Muscle of a patient with AIDS Journal of Infection 51, e139-e144. http://dx.doi.org/10.1016/j.jinf.2004.11.006

Ennouri M, Evelyne B, Laurence M, Hamadi A. 2005. Fatty Acid Composition and Rheological Behaviour of Prickly Pear Seed Oils. Food Chemistry 93, 431-437. http://dx.doi.org/10.1016/j.foodchem.2004.10.020

Fodili F, Van Bommel EFH. 2003. Severe Rhabdomyolysis and Acute Renal Failure following recent Coxsackie B Virus Infection. The Netherlands Journal of Medicine 61, 177-179.

Friswell M, Campbell B, Rhodes J. 2010. The Role of Bacteria in the Pathogenesis of Inflammatory Bowel Disease. Gut and Liver 4, 295-306. http://dx.doi.org/10.5009/gnl.2010.4.3.295

Galanis E, Hoang L, Kibsey P, Morshed M, Phillips P. 2009. Clinical presentation, Diagnosis and Management of Cryptococcus Gattii cases: Lessons learned from British Columbia. Canadian Journal of Infectious Diseases and Medical Microbiology 20, 23-28. http://dx.doi.org/10.1155/2009/719659

Galati EM, Mondello MR, Giuffrida D, Dugo G, Miceli N, Pergolizzi S, Taviano MF. 2003. Chemical Characterization and Biological effects of Sicilian Opuntia ficus indica (L.) Mill. Fruit Juice: Antioxidant and Antiulcerogenic activity. Journal of Agricultural and Food Chemistry 51, 4903-4908. http://dx.doi.org/10.1021/jf030123d

Hwang SH, Kang ILJ, Lim SS. 2017. Antidiabetic Effect of Fresh Nopal (Opuntia ficus-indica) in Low-Dose Streptozotocin-Induced Diabetic Rats Fed a High-Fat Diet. Evidence-Based Complementary and      Alternative Medicine   1-8. http://dx.doi.org/10.1155/2017/4380721

Katz DS, Wogalter H, D’Esposito RF, Cunha BA. 1992. Mycobacterium Bovis Vertebral Osteomyelitis and Psoas Abscess after Intravesical BCG Therapy for Bladder Carcinoma. Urology 40, 63-66. http://dx.doi.org/10.1016/0090-4295(92)90439-4

Kohtaro A, Shimokawa H, Kubota T, Nawa Y, Takeshita A. 2002. Myocarditis associated with Visceral Larva Migrans due to Toxocara canis. Internal Medicine 41, 706-708. http://dx.doi.org/10.2169/internalmedicine.41.706

Mosqueda J, Olvera-Ramírez A, Aguilar-Tipacamú G, Cantó GJ. 2012. Current Advances in Detection and Treatment of Babesiosis. Current Medicinal Chemistry 19, 1504-1518. http://dx.doi.org/10.2174/092986712799828355

Park EH, Kahng JH, Lee SH, Shin KH. 2001. An Anti-inflammatory principle from Cactus. Fitoterapia 72, 288-290. http://dx.doi.org/10.1016/S0367-326X(00)00287-2

Patel S. 2012. Reviewing the Prospects of Opuntia Pears as Low Cost Functional Foods. Reviews in Environmental Science and Bio/Technology 12, 223-234. http://dx.doi.org/10.1007/s11157-012-9295-6

Peiris JSM, de Jong MD, Guan Y. 2007. Avian Influenza Virus (H5N1): a Threat to Human Health. Clinical Microbiology Reviews 20, 243-267. http://dx.doi.org/10.1128/CMR.00037-06

Perfumi M, Tacconi R. 1996. Antihyperglycemic effect of Fresh Opuntia dillenii Fruit from Tenerife (Canary Islands). International Journal of Pharmacognosy 34, 41-47. http://dx.doi.org/10.1076/phbi.34.1.41.13186

Philip K, Abd Malek SN, Sani W, Shin SK, Kumar S, Lai HS, Serm LG, Rahman SNSA. 2009. Antimicrobial Activity of some Medicinal Plants from Malaysia. American Journal of Applied Sciences 6, 1613-1617. http://dx.doi.org/10.3844/ajassp.2009.1613.1617

Winter CA, Risely EA, Nuss GW. 1962. Carrageenan Induced Edema in Hind Paw of the Rat as an Assay for Anti-inflammatory Drugs. Proceedings of the Society for Experimental Biology and Medicine 111, 544. http://dx.doi.org/10.3181/00379727-111-27849