Phytochemical property and oral toxicity safety of Chrysophyllum caimito and Psidium guajava extracts

Paper Details

Research Paper 11/02/2023
Views (578) Download (94)
current_issue_feature_image
publication_file

Phytochemical property and oral toxicity safety of Chrysophyllum caimito and Psidium guajava extracts

Roel T. Calagui
J. Bio. Env. Sci.22( 2), 18-25, February 2023.
Certificate: JBES 2023 [Generate Certificate]

Abstract

The century-old practice of herbal medication in animals still persists in local communities despite the contemporary advances in veterinary health care today. The numerous benefits including convenience of use, accessibility, inexpensiveness and insignificant side effects when compared to synthetic veterinary medicines in which drug resistance and residuals are linked. This research work aimed to elucidate the presence of bioactive components and determine the margin of safety of Chrysophyllum cainito (Caimito) and Psidium guajava (Guava) ethanolic bark extracts which are among the selection of documented herbals reliably utilized for gastro-intestinal sicknesses in farm animals. Qualitative phytochemical screening exemplified the presence of tannins, saponins, terpenoids, xanthoproteins, steroids and coumarin. Avian acute oral toxicity testing denoted that 2000mg/kg dosage was adequate and safe to use in Sasso chickens as substantiated by insignificant effect to body weight, SGOT and uric acid values and the non-appearance of toxicity symptoms including death. The secondary metabolites demonstrated in these plants explicate the pharmacological activities which can be utilized as potential alternatives to current medication strategies in animals.

VIEWS 133

Abdel Aziz AR, Abou Laila MR, Aziz M, Omar MA, Sultan K. 2018. In vitro and in vivo anthelmintic activity of pumpkin seeds and pomegranate peels extracts against Ascaridia galli. Beni-Suef University Journal of Basic and Applied Sciences 7, 231-234.

Al-Snafi AE. 2016. Antiparasitic effects of medicinal plants (part 1) – A review. IOSR Journal of Pharmacy 6, 51-66.

Argentieri MP, DAddabbo T, Tava A, Agostinelli A, Jurzysta M, Avato P. 2008. Evaluation of nematicidal properties of saponins from Medicago spp. European Journal of Plant Pathology 120, 189-197.

Behnke JM, Buttle DJ, Stepek G, Lowe A, Duce IR. 2008. Developing novel anthelmintics from plant cysteine proteinases. Parasites & Vectors 1, 29.

Bhagavathy S, Mahendiran C, Kanchana R. 2018. Identification of glucosyl transferase inhibitors from Psidium guajava against Streptococcus mutans in dental caries. Journal of Traditional and Complementary Medicine p. 1-14.

Borji H, Razmyar J. 2012. Aberrant migration of Ascaridia galli in a Myna (Acridotheres tristis). Scientia Parasitologia 13, p. 129-131.

Botura MB, dos Santos JD, da Silva GD, de Lima HG, de Oliveira JV, de Almeida MA, Batatinha MJ, Branco A. 2013. In vitro ovicidal and larvicidal activity of Agave sisalana Perr. (Sisal) on gastrointestinal nematodes of goats. Veterinary Parasitology 192, 211-217.

Catibog-Sinha CS, Heaney LR. 2006. Philippine Biodiversity: Principles and Practice. Quezon City, Philippines: Haribon Foundation for the Conservation of Natural Resources, Inc.

Dixon RA, Sumner LW. 2003. Legume natural products: Understanding and manipulating complex pathways for human and animal health. Plant Physiology 131, 878-885.

Doan HV, Riyajan S, Iyara R, Chudapongse N. 2018. Antidiabetic activity, glucose uptake stimulation and α-glucosidase inhibitory effect of Chrysophyllum cainito L. stem bark extract. BMC Complementary Alternative Medicine 18(1), 267.

Doligalska M, Jo´zwicka K, Kiersnowska M, Mroczek A, Paczkowski C, Janiszowska W. 2011. Triterpenoid saponins affect the function of P-glycoprotein and reduce the survival of the free-living stages of Heligmosomoides bakeri. Veterinary Parasitology 179, 144-151

Ekeleme K, Tsaku P, Nkene I, Ufomadu U, Abimiku R, Oti V, Sidi M. 2017. Phytochemical analysis and antibacterial activity of Psidium guajava L. leaf extracts. GSC Biological and Pharmaceutical Sciences 01(02), 013-019.

Fernandez Jr TJ, Portugaliza HP, Braga FB, Vasquez EA, Acabal AD, Divina BP. 2013. Effective dose (ED) and quality control studies of the crude ethanolic extract (CEE) mixture of makabuhay, caimito and makahiya (MCM) as dewormer for goats against Haemonchus contortus. Asian J Exp Biol Sci 4(1), 28-35

Food and Agriculture Organization of the United Nations (FAO). 1992. Traditional Veterinary Medicine in the Phlippines. FAO/APHCA Publication No.13.

Food and Drug Administration. 2012. Guidance #209: the Judicious Use of Medically Important Antimicrobial Drugs in Food-Producing Animals.

Gayathri V, Kiruba D. 2014. Preliminary Phytochemical Analysis of Leaf Powder Extracts of Psidium guajava L. International Journal of Pharmacognosy and Phytochemical Research 6(2), 332-334.

Giri BR, Bharti RR, Roy R. 2015. In vivo anthelmintic activity of Carex baccans and its active principle resveratrol against Hymenolepis diminuta. Parasitology Research 114, 785-788.

Guevarra B. 2005. A guidebook to phytochemical screening: phytochemical and biological. Manila: UST Publishing House.

Guzman LS. 2015. Non-Experimental Validation of the Effectiveness of Ethno-Veterinary Botanical Medicine (EVB-M) Materials Used in the Municipality of Echague Isabela. Journal of Agricultural Technology 11(8), 2377-2389.

Idris OA, Wintola OA, Afolaya AJ. 2017. Phytochemical and antioxidant activities of Rumex crispus L. in treatment of gastrointestinal helminths in Eastern Cape Province, South Africa. Asian Pacific Journal of Tropical Biomedicine p. 1-8.

Jain NC. 1993. Essential of Veterinary Hematology, Lea & Febiger, Philadelphia.

Kamath JV, Rahul N, Ashok Kumar CK, Lakshmi SM. 2008. Psidium guajava L: A review. International Journal of Green Pharmacy 223, 225-254.

Katiki LM, Chagas ACS, Bizzo HR, Ferreira JFS, Amarante AFT. 2011. Anthelmintic activity of Cymbopogon martinii, Cymbopogon schoenanthus and Mentha piperita essential oils evaluated in four different in vitro tests. Veterinary Parasitology 183, 103-108.

Khan A, Tak H, Nazir R, Lone BA. 2016. In vitro and in vivo anthelmintic activities of Iris kashmiriana Linn. Journal of the Saudi Society of Agricultural Sciences.

Macedo I, Bevilaqua C, de Oliveira L, Camurca-Vasconcelos A, Morais S, Machado L, Ribeiro W. 2012. In vitro activity of Lantana camara, Alpinia zerumbet, Mentha villosa and Tagetes minuta decoctions on Haemonchus contortus eggs and larvae. Veterinary Parasitology 190, 504- 509.

Meluzzi A, Primiceri G, Giordani RA, Fabris G. 1991. Determination of blood constituents’ reference values in broilers. Poultry Science 71, 337-345.

Mishra R, Tiwari P, Srivastava M, Singh C, Ghoshal S. 2017. A comprehensive review on Psidium guajava Linn (Amaratafalam). International Journal of Ethnobiology & Ethnomedicine 4(1), 1-6.

Molan AL, Alexander RA, Brookes IM, McNabb WC, Peterson SW. 2000. Effects of an extract from sulla (Hedysarum coronarium) containing condensed tannins on the migration of three sheep gastrointestinal nematodes in vitro. In: Proceedings of the New Zealand Society of Animal Production 60, 21-25.

Nabukenya I, Rubaire-Akiiki C, Olila D, Ikwap K, Hoglund J. 2014. Ethnopharmacological practices by livestock farmers in Uganda: Survey experiences from Mpigi and Gulu districts. Journal of Ethnobiology and Ethnomedicine 10, 9.

Nagappan R. 2012. Evaluation of aqueous and ethanol extract of bioactive medicinal plant, Cassia didymobotrya (Fresenius) Irwin & Barneby against immature stages of filarial vector, Culex quinquefasciatus Say (Diptera: Culicidae). Asian Pacific Journal of Tropical Biomedicine 2(9), 707-711.

Ngbolua K, Lufuluabo LG, Moke LE,. Bongo GN, Liyongo CI, Ashande CM, Sapo BS, Zoawe BG, Mpiana PT. 2018. A review on the Phytochemistry and Pharmacology of Psidium guajava L. (Myrtaceae) and Future direction. Discovery Phytomedicine 5(2), 7-13.

Organisation for Economic Corporation and Development (OECD). 2016. Avian Acute Oral Toxicity Test. Guidelines for the Testing of Chemicals (OECD 223).

Parthiban R, Vijayakumar S, Prabhu S, Gnanaselvam J, Yabesh EM. 2016. Quantitative traditional knowledge of medicinal plants used to treat livestock diseases from Kudavasal taluk of Thiruvarur district, Tamil Nadu, India. Revista Brasileira de Farmacognosia 109-121.

Pereira AV, Santana GM. 2015. Tannins obtained from medicinal plants extracts against pathogens: antimicrobial potential. The Battle Against Microbial Pathogens: Basic Science, Technological Advances and Educational Programs 228-234.

Posyniak A, Mitrowska K. 2008. Analytical procedure for the determination of fluoroquinolones in animal muscle. Bull Vet Inst Pulawy 27-430.

Shailajan S, Gurjar D. 2014. Pharmacognostic and Phytochemical Evaluation of Chrysophyllum cainito Linn. Leaves. International Journal of Pharmaceutical Sciences Review and Research 17, 106-111.

Suroowan S, Javeed F, Ahmad M, Zafar M, Noor MJ, Kayani S, Javed A, Mahomoodally MF. 2017. Ethnoveterinary health management practices using medicinal plants in South Asia – a review. Veterinary Research Communications 41, 147-168.

Wadood A, Ghufran M, Jamal SB, Naeem M, Khan A. 2013. Phytochemical Analysis of Medicinal Plants Occurring in Local Area of Mardan. Biochem Anal Biochem 2, 144.

Waller P. 2006. Sustainable nematode parasite control strategies for ruminant livestock by grazing management and biological control. Animal Feed Science Technology 126, 277-289.

Weli A, Al-Kaabi A, Al-Sabahi J, Said S, Hossain MA, Al-Riyami S. 2018. Chemical composition and biological activities of the essential oils of Psidium guajava leaf. Journal of King Saud University Science.

Yigezu Y, Haile DB, Ayen WY. 2014. Ethnoveterinary medicines in four districts of Jimma zone, Ethiopia: cross sectional survey for plant species and mode of use. BMC Veterinary Research 10, 76.

Zuharah WF, Ling CJ, Zulkifly N, Fadzly N. 2015. Toxicity and sub-lethal effect of endemic plants from family Anacardiaceae on oviposition behavior of Aedes albopictus. Asian Pacific Journal of Tropical Biomedicine 5(8), 612.