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Phytoconstituents and Pharmacological Profile of Echinacea purpurea

Research Paper | September 1, 2021

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Mehwish Qayyum, Mubashra Gul, Mayyda Asif Bajwa, Rashida Perveen, Kanwal Ashiq, Maria Gul, Waqas Noor, Hina Awais

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Int. J. Biosci.19( 3), 66-72, September 2021

DOI: http://dx.doi.org/10.12692/ijb/19.3.66-72


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Echinacea purpurea (Asteraceae) is a medicinal herb that has broad spectra of pharmacological properties. It is a perennial herb with immune-stimulant and anti-inflammatory properties. Due to its vast pharmacological properties, this plant has attracted the attention of scientists to evaluate other beneficial biological effects. The plant has shown antidepressant, anxiolytic, anti-mutagenic, cytotoxic, antifungal and antibacterial properties. The objective of this review is to highlight the importance of Echinacea purpurea. Different databases were used to search literature in the English language. Clinical studies are still not found due to its adverse effects. But some plant studies have shown the best biological responses, with no serious side effects, while some studies have reported severe adverse effects on the skin such as rashes, urticaria and itching, abdominal cramps, pain, nausea and labored breathing. Cichoric acid and alkamides analysis have been developed by high-performance liquid chromatography (HPLC) by using different detectors, for example, coulometric detectors, ionization mass spray detectors and Uv-vis detectors. Instead of controversial results of different studies on this plant, some activities show the best results, But some questions are still there. Echinacea purpurea plant has a lot of work that needs to be done in the future by considering the mechanism of action.


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Phytoconstituents and Pharmacological Profile of Echinacea purpurea

Barnes J, Anderson LA, Gibbons S, Phillipson JD. 2005. Echinacea species (Echinacea angustifolia (DC.) Hell. Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties. Journal of Pharmacy and Pharmacology 57(8), 929-54. https://doi.org/10.1211/0022357056127

Barrett B. 2003. Medicinal properties of Echinacea: a critical review. Phytomedicine 10(1), 66-86. https://doi.org/10.1078/094471103321648692

Barrett B. Medicinal properties of Echinacea: a critical review. 2003. Phytomedicine 10(1), 66-86. https://doi.org/10.1078/094471103321648692

Bergmann KC. 1995. Assessment of the clinical value of using an immunomodulator in recurrent respiratory infections. Advances in experimental medicine and biology 371, 795-7.

Canlas J, Hudson JB, Sharma M, Nandan D. 2010. Echinacea and trypanasomatid parasite interactions: growth-inhibitory and anti-inflammatory effects of Echinacea. Pharmaceutical Biology 48(9), 1047-52. https://doi.org/10.3109/138802009034834.68

Chaves F, Chacón M, Badilla B, Arévalo C. 2007. Effect of Echinacea purpurea (Asteraceae) aqueous extract on antibody response to Bothrops asper venom and immune cell response. Revista de biología tropical 55(1), 113-9.

Chicca A, Adinolfi B, Martinotti E, Fogli S, Breschi MC, Pellati F, Benvenuti S, Nieri P. 2007. Cytotoxic effects of Echinacea root hexanic extracts on human cancer cell lines. Journal of Ethnopharmacology 110(1), 148-53. https://doi.org/10.1016/j.jep.2006.09.013

Clifford LJ, Nair MG, Rana J, Dewitt DL. 2002. Bioactivity of alkamides isolated from Echinacea purpurea (L.) Moench. Phytomedicine 9(3), 249-53. https://doi.org/10.1078/0944-7113-00105

Gertsch J, Schoop R, Kuenzle U, Suter A. 2004. Echinacea alkylamides modulate TNF-α gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways.FEBS-letters 577(3), 563-9. https://doi.org/10.1016/j.febslet.2004.10.064

Ghalamkari GR, Landy N, Toghyani M, Moatar F, Abed Esfahani A, Araj Shirvani M. 2011. Efficiency of Echinacea purpurea L. on total anti-oxidant activity in serum of broiler chicks. Journal of Medicinal Herbs 1(4), 7-14.

Goel V, Chang C, Slama JV, Barton R, Bauer R, Gahler R, Basu TK. 2002. Alkylamides of Echinacea purpurea stimulate alveolar macrophage function in normal rats. International immunopharmacology 2(2-3), 381-7. https://doi.org/10.1016/S1567-5769(01)00163-1

Goel V, Chang C, Slama JV, Barton R, Bauer R, Gahler R, Basu TK. 2002. Echinacea stimulates macrophage function in the lung and spleen of normal rats. The Journal of nutritional biochemistry 13(8), 487-92. https://doi.org/10.1016/S0955-2863(02)00190-0

Grimm W, Müller HH. 1999. A randomized controlled trial of the effect of fluid extract of Echinacea purpurea on the incidence and severity of colds and respiratory infections. The American journal of medicine 106(2), 138-43. https://doi.org/10.1016/S0002-9343(98)00406-9

Hao DC, Gu XJ, Xiao PG, Hao DC, Gu XJ, Xiao PG. 2015. Phytochemical and biological research of Salvia medicinal resources. Medicinal plants 4, 587-639.

Jungmin Lee, Carolyn F, Scagel. 2013. Chichoric acid ,chemistry ,distribution and production written by.US Department of agriculture ,agri research service .Horticultural crops research unit woksite parma, ID, USA. https://doi.org/10.3389/fchem.2013.00040

Laasonen M, Wennberg T, Harmia-Pulkkinen T, Vuorela H. 2002.  Simultaneous analysis of alkamides and caffeic acid derivatives for the identification of Echinacea purpurea, Echinacea angustifolia, Echinacea pallida and Parthenium integrifolium roots. Planta medica 68(06), 572-4. https://doi.org/10.1055/s-2002-32561

Lee TT, Huang CC, Shieh XH, Chen CL, Chen LJ, Yu BI. 2010.  Flavonoid, phenol and polysaccharide contents of Echinacea purpurea L. and its immunostimulant capacity in vitro. International Journal of Environmental Science and Development 1(1), 5.

Manayi A, Vazirian M, Saeidnia S. 2015. Echinacea purpurea: Pharmacology, phytochemistry and analysis methods. Pharmacognosy Reviews 9(17), 63. https://doi.org/10.4103/0973-7847.156353

McKeown KA. 1999. A review of the taxonomy of the genus Echinacea. Perspectives on New Crops and New Uses 482, 489.

Mengs U, Clare CB, Poiley JA. 1991. Toxicity of Echinacea purpurea. Acute, subacute and genotoxicity studies. Arzneimittel-forschung 41(10), 1076-81.

Patel T, Crouch A, Dowless K, Freier D. 2008. 122 Acute effects of oral administration of a glycerol extract of Echinacea purpurea on peritoneal exudate cells in female swiss mice. Brain Behavior and Immunity 4(22), 39. https://doi.org/10.1016/j.bbi.2008.04.124

Saeidnia S, Gohari AR, Mokhber-Dezfuli N, Kiuchi F. 2011. A review on phytochemistry and medicinal properties of the genus Achillea. DARU: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences 19(3), 173.

Shaffique S, Rehman A, Ahmad S, Anwer H, Asif HM, Husain G, Rehman T, Javed S. 2018. A Panoramic Review on Ethnobotanical, Phytochemical, Pharmacological and Homeopathic Uses of Echinacea angustifolia. RADS Journal of Pharmacy and Pharmaceutical Sciences 6(4), 282-6.

Sharma M, Anderson SA, Schoop R, Hudson JB. 2009. Induction of multiple pro-inflammatory cytokines by respiratory viruses and reversal by standardized Echinacea, a potent anti-viral herbal extract. Anti-viral research 83(2), 165-70. https://doi.org/10.1016/j.antiviral.2009.04.009

Sharma M, Vohra S, Arnason JT, Hudson JB. 2008. Echinacea. Extracts contain significant and selective activities against human pathogenic bacteria. Pharmaceutical Biology 46(1-2), 111-6 https://doi.org/10.1080/13880200701734919

Soudi S, Hashemi SM, Zavaran Hosseini A, Ghaemi A, Asghari Jafarabadi M. 2010. Antileishmanial effect of Echinacea purpurea root extract cultivated in Iran. Iranian Journal of Pharmaceutical Research 20(2), 47-9. https://doi.org/10.22037/IJPR.2010.713

Stanisavljević I, Stojičević S, Veličković D, Veljković V, Lazić M. 2009. Anti-oxidant and antimicrobial activities of Echinacea (Echinacea purpurea L.) extracts obtained by classical and ultrasound extraction. Chinese Journal of Chemical Engineering 17(3), 478-83. https://doi.org/10.1016/S1004-9541(08)60234-7

Steinmüller C, Roesler J, Gröttrup E, Franke G, Wagner H, Lohmann-Matthes ML. 1993. Polysaccharides isolated from plant cell cultures of Echinacea purpurea enhance the resistance of immunosuppressed mice against systemic infections with Candida albicans and Listeria monocytogenes. International Journal of Immunopharmacology 15(5), 605-14. https://doi.org/10.1016/0192-0561(93)90078-D

Vimalanathan S, Kang L, Amiguet VT, Livesey  J, Arnason JT, Hudson J. 2005. Echinacea purpurea. aerial parts contain multiple anti-viral compounds. Pharmaceutical biology 43(9), 740-5. https://doi.org/10.1080/13880200500406354

Wang CY, Staniforth V, Chiao MT, Hou CC, Wu HM, Yeh KC, Chen CH, Hwang PI, Wen TN, Shyur LF, Yang NS. 2008.  Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells. BMC genomics 9(1), 1-20.