Paper Details

Phytotoxic and cytotoxic characterization of crude methanolic extract of Plumeria 0btusa

Zakir Khan, RubinaNaz, Shakil Abbas, Mushtaq Ahmad, Wasim Ahmed, ZiaulHaq, Farmanullah Khan

DOI: https://dx.doi.org/10.12692/ijb/5.10.46-50

Int. J. Biosci. 5(10), 46-50. November, 2014. (PDF)

Abstract:

Plumeria Obtusa belongs to the family Apocynacea; it has been utilized in tropical regions as medicine for the treatment of itches, swellings and fever. In this research investigation, phytotoxic characterization of crude methanolic extract of P.obtusa was tested on the germination of maize seeds. The extract showed inhibitory effect on the germination of the growth of root and shoot of the seedlings. The inhibitory result showed dose dependency. The maximum concentration of 1000 μg/ml showed maximum inhibitory effect on the growth of root and shoots.  Similarly the presence of anti-tumorous compounds was also studied on Brine Shrimps by performing cytotoxic activity. The extract  showed 100% shrimps deaths at 1000µg/ml. This confirmed the presence of anti-tumorous compounds in the plant which can further be isolated for the preparation of numerous drugs.