Predictive effects (study in silico) of cadmium/fungicide cocktail on biomarkers of snail oxidative stress: Cantareus aspersus (Müller, 1774) using the forecasting grey model GM (1, N)

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Research Paper 05/12/2022
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Predictive effects (study in silico) of cadmium/fungicide cocktail on biomarkers of snail oxidative stress: Cantareus aspersus (Müller, 1774) using the forecasting grey model GM (1, N)

Khadidja Farfar, Amira Youbi, Mohamed El Taher Kimour, Mohamed El Hadi Khebbeb, Mohamed Reda Djebar, Zihad Bouslama
Int. J. Biosci.21( 6), 197-205, December 2022.
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In this study, we were interested in the physiological and biochemical predicted effects of a copper-based fungicide (Vacomil-PLUS) (0.5, 1 and 2g/l), cadmium (200, 400, 800µg/l) and their mixtures (CdCl2 + Copper fungicide, 1/1, V/V) on bio-indicator organisms of pollution: the snail Cantareus aspersus. Our work consists in predicting the long-term effect of these xenobiotics using the forecasting grey model (1, N) as a predicting model. To our knowledge, this is the first study evaluating the predictive effects of toxicants on the snail Cantareus aspersus, using a computer prediction model. Our predictive results obtained from the modeling of predictive values, using the Grey model show that the presence of cadmium and/or fungicide causes growth inhibition of the treated animals, thus reducing the weight of the digestive gland. In addition, more disturbances that are significant also noted in the biochemical composition of the hepatopancreas of Cantareus aspersus (total proteins) after treatment with the cadmium/fungicide mixture. Monitoring of oxidative stress biomarkers shows disturbances due to contamination by these pollutants. We revealed an induction of MDA as well as a depletion of the GSH level, testifying to the occurrence of lipid peroxidation. Finally, cadmium, copper-based fungicide and their mixture significantly inhibits AChE activity.


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