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Preparation and Antimicrobial Evaluation of 3, 5-Disubstituted Tetrahydro-2H-1, 3, 5-Thiadiazine-Thione Derivatives

Nuzhat Arshad, Anjum Ayub, Rafia Usman Khan, Jamshed Hashim, Shumaila Jawaid, Mahreen Lateef, Maha Shareef

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Int. J. Biosci.19(2), 248-253, August 2021

DOI: http://dx.doi.org/10.12692/ijb/19.2.248-253


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Fourteen derivatives of tetrahydro-2H-1, 3, 5-thiadiazine-2-thiones with different functional groups were synthesized and evaluated for their antibacterial activity against gram negative and positive bacteria by utilizing disc diffusion method and recorded as zone of inhibition in milli meter and compared with standard drug Streptomycin. The results showed that two compounds namely 6d and 7a having 2-phenyl ethyl at N-3 position had significant antibacterial activity against Salmonella typhi, similar to the standard drug streptomycin however all other synthesized compounds were found weakly active towards different tested bacterias.


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