Prevalence and associations of thyroid dysfunction with metabolic markers blood glucose and lipid profile: A cross-sectional study

Paper Details

Research Paper 06/10/2023
Views (595) Download (26)

Prevalence and associations of thyroid dysfunction with metabolic markers blood glucose and lipid profile: A cross-sectional study

Aziz Ur Rehman, Faisal Khan, Muhammad Abbas, Abdullah, Ashfaq Ahmad, Kashif Ahmad, Syed Rabnawaz Shah, Abdur Rehman
Int. J. Biomol. & Biomed.17( 2), 7-12, October 2023.
Certificate: IJBB 2023 [Generate Certificate]


Thyroid hormone contains two vital hormones. Triiodothyronine (T3) and thyroxine (T4), are necessary for regulating metabolism, including glucose homeostasis, lipid metabolism, and cholesterol synthesis. In this cross-study, a total of 199 patients both males and females included, investigated the interrelation between thyroid function test, lipid profile, and Random blood sugar which were shown to be significant because these are the main factor that affects thyroid hormone and data was analyzed using SPSS version 25. The results suggest that thyroid function plays a role in metabolic health. Furthermore, a significant relationship was identified between TSH and random blood sugar (RBS) that can cause hypoglycemia, indicating a potential link between thyroid function. The mean and standard deviation of T3 is 2.1 ± 2.5ng/ml, T4 3.8 ± 5.9 P mol/L, TSH 5.4 ± 13.3 PIU/ml, RBS 100 ± 45mg/dl which is on the lower limit, TG 200 ± 45mg/dl, Cholesterol 201 ± 25mg/dl are on upper limit can cause dyslipidemia. There is a negative association between TSH and random blood sugar with P< 0.05. These findings have implications for understanding thyroid disorders and their impact on metabolic health.


Akbar DH, Ahmed MM, Al-Mughales J. 2006. Thyroid dysfunction and thyroid autoimmunity in Saudi type 2 diabetics. Acta Diabetol 43(1), 14-18. DOI: 10.1007/s00592-006-0204-8

Al-Fatlawi, Abeer Cheaid Yousif %J Biomedicine. 2022. An evaluation of blood glucose and lipid profile in female hypothyroidism patients in Kerbala province, Iraq 42(3), 556-560.

Attaullah S, Haq BS, Muska M. 2016. Thyroid dysfunction in Khyber Pakhtunkhwa, Pakistan. Pak J Med Sci 32(1), 111-115. DOI:10.12669/pjms.321.8476

Attaullah, Shahnaz, Mohammadzai, Imdadullah, Ahmad, Jawad, Haq, Bibi Safia, & Wadud, Umair%J Journal of Medical Sciences. 2015. Thyroid dysfunction and its effect on serum lipids 23(1), 34-37.

Ding Xi, Zhao Yang, Zhu Chun-Ying, Wu Li-Ping, Wang Yue, Peng Zhao-Yi, Shi Bing-YinJ Endocrine Journal. 2021. The association between subclinical hypothyroidism and metabolic syndrome: an update meta-analysis of observational studies 68(9), 1043-1056.

Duntas, Leonidas H %J Thyroid. 2002. Thyroid disease and lipids 12(4), 287-293.

Kim WG, Kim WB, Woo G, Kim H, Cho Y, Kim TY, Chung JH. 2017. Thyroid Stimulating Hormone Reference Range and Prevalence of Thyroid Dysfunction in the Korean Population: Korea National Health and Nutrition Examination Survey 2013 to 2015. Endocrinol Metab (Seoul) 32(1), 106-114. DOI: 10.3803/EnM.2017.32.1.106

Kocaturk E, Kar E, Kusku Kiraz Z, Alatas O. 2020. Insulin resistance and pancreatic beta cell dysfunction are associated with thyroid hormone functions: A cross-sectional hospital-based study in Turkey. Diabetes Metab Syndr 14(6), 2147-2151. DOI: 10.1016/j.dsx.2020.11.008

Kube I, Zwanziger D. 2020. Thyroid Dysfunction and Cholesterol Gallstone Disease. Exp Clin Endocrinol Diabetes 128(6-07), 455-461. DOI: 10. 1055 /a-1033-7273

Kyriacou A, McLaughlin J, Syed AA. 2015. Thyroid disorders and gastrointestinal and liver dysfunction: A state of the art review. Eur J Intern Med 26(8), 563-571. DOI: 10.1016/j.ejim.2015.07.017

Langer P, Hanzen E, Tajtakova M, Putz Z, Kreze A, Sebokova E, Klimes I. 1997. High lipid levels in Slovak rural population. Consequence of thyroid dysfunction or nutritional status? Ann N Y Acad Sci 827, 568-574. DOI: 10.1111/j.1749-6632.1997.

Rizos CV, Elisaf MS, Liberopoulos EN%J The open cardiovascular medicine journal. 2011. Effects of thyroid dysfunction on lipid profile 5, 76.

Kung AW, Pang RW, Janus ED. 1995. Elevated serum lipoprotein (a) in subclinical hypothyroidism. Clinical endocrinology 43(4), 445-9.

Luboshitzky R, Aviv A, Herer P, Lavie L. 2002. Risk factors for cardiovascular disease in women with subclinical hypothyroidism. Thyroid. May 1; 12(5), 421-5.

Stagnaro-Green, Alex, Dong, Allan, Stephenson, Mary D%J Best practice, endocrinology, research Clinical, & metabolism. 2020. Universal screening for thyroid disease during pregnancy should be performed 34(4), 101320.

Stuijver DJ, van Zaane B, Gerdes VE, Stroes ES. 2012. [Screening for thyroid dysfunction in dyslipidaemia patients]. Ned Tijdschr Geneeskd 156(2), A4301.

Tan KCB, Shiu SWM, Kung AWC%J The Journal of Clinical Endocrinology, & Metabolism. 1998. Plasma cholesteryl ester transfer protein activity in hyper and hypothyroidism 83(1), 140-143.

Duntas LH, Brenta G. 2016. Thyroid hormones: a potential ally to LDL-cholesterol-lowering agents. Hormones 15(4), 500-10.

Attaullah S, Haq BS, Ahmed Z. 2015. Correlation of thyroid dysfunction with serum creatinine. Int J Multidiscip Res Dev 2(8), 88-90.

Zuarth-Vázquez, Julia, Moreno-Castañeda, Lidia, Soriano-Márquez, Juan Pablo, Velázquez-Alemán, Alain, Ramos-Ostos, Martha Helena, Uribe, Misael, Juárez-Hernández, Eva%J Life. 2023. Low–Normal Thyroid Function Is Not Associated with Either Non-Alcoholic Fatty Liver Disease or with Metabolic Dysfunction-Associated Fatty Liver Disease 13(4), 1048.