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Prevalence of systemic sclerosis and atherosclerosis: A systemic review and meta-analysis

Hayaa M Alhuthali, Saeedah H Aljadani, Hind Ali Alzahrani, Saba Beigh

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Int. J. Biosci.20(3), 232-249, March 2022

DOI: http://dx.doi.org/10.12692/ijb/20.3.232-249


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Systemic sclerosis (SSc) and atherosclerosis-related diseases are among the most diagnosed diseases persisting globally. In agreement with earlier publications, we wanted to determine the prevalence of SSc and atherosclerosis. Thorough systematic searches of published studies across various countries in Embase, Medline, Web of Science, Scopus, and PubMed were performed to update our systemic review from January 1990 to December 2020. The author/s, year of publication, sampling size, Mortality, Study design, the prevalence of a particular Sex in that study, mean age, follow up years, limited cutaneous systemic sclerosis (LcSSc) patients, disease duration, body mass index, the prevalence for various symptoms of SSc and NOS of the selected study were explored in this study. The search yielded 1191 articles among which 81 articles were finally encompassed in this study. Among these selected 81 articles, 63 were related to Atherosclerosis among which 29 and 34 articles were prospective and retrospective studies respectively. The studies related to atherosclerosis involved a total of 43, 60,282 participants with their average age of mortality as 54.68 patients per 1000 individuals among the prevalent persons of the disease. However, 18 articles were related to Systemic Sclerosis involving 5821 patients with mean age 53.79 years. This study revealed that the SSc and atherosclerosis symptoms correlate with each other and SSc increases the prevalence of atherosclerosis. SSc patients are at higher risk of having atherosclerotic diseases especially cardiovascular diseases and on the diagnosis of SSc in the patients. As a result, preventative actions for atherosclerotic disorders must be adopted.


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Prevalence of systemic sclerosis and atherosclerosis: A systemic review and meta-analysis

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