Prospects of kidney stone management by phytotherapy: A review

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Review Paper 01/09/2020
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Prospects of kidney stone management by phytotherapy: A review

Muhammad Sarwar Yaqub, Rozina Aslam
Int. J. Biosci.17( 3), 67-73, September 2020.
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Causes of kidney stone formation, types of kidney stones, some frequently used medicinal plants to cure kidney stones and their pharmacological action are reviewed in this article. Kidney stones are major threat to human life and cause economic burden on human population. Studies on treatment of kidney stones by medicinal plants searching for lithotriptic activity of plants need attention. During this study, it was found that medicinal plants are the most effective source for the treatment of kidney stones. The main objective of this study was to explore the efficacy and availability of medicinal plants as an alternative and to provide economical, side effect free, environment friendly, and easily available treatment to reduce the burden of urolithiasis on patients and healthcare management.


Abrams SA. 2001. Calcium turnover and nutrition through the life cycle. Proceedings of the Nutrition Society 60(2), 283-289.

Ahmad, S, Shad MA, Ansari TM. 2016. Prevalence of renal calculi. The Professional Medical Journal 23(04), 389-395.

Agarwal S, Gupta SJ, Saxena A, Gupta N, Agarwal S. 2010. Urolithic property of Varuna (Crataeva nurvala): An experimental study. Ayu 31, 361–366.

Akram M, Idrees M. 2019. Progress and prospects in the management of kidney stones and developments in phyto- therapeutic modalities. International journal of immunopathology and Pharmacology 33, 1-5.

Aslam R, Aslam M, Abdullaha S, Yaqub MS. 2019. Licorice a supernatural herb for healthy life: Bioactive phytochemicals and biological activities – A Review Journal of Horticultural Science and Technology 2, 34-40.

Atmani F, Slimani Y, Mimouni M, Hacht B. 2003. Prophylaxis of calcium oxalate stones by Herniaria hirsuta on experimentally induced nephrolithiasis in rats. BJU International 92, 137–140.

Baker PW, Coyle P, Bais R, Rofe AM. 1993. Influence of season, age, and sex on renal stone formation in South Australia. The Medical Journal of Australia 159, 390-392.

Castro-Torres IG, Naranjo-Rodriguez EB, Dominguez-Ortiz MA, Gallegos-Estudillo J, Saavedra-Velezl MV. 2012. Antilithiasic and hypolipidaemic effects of Raphanus sativus L. var. niger on mice fed with a lithogenic diet. Journal of Biomedicine and Biotechnology 2012, 1-8.

Chaudhary A, Singla S, Tandon C. 2010. In vitro evaluation of Terminalia arjuna on calcium phosphate and calcium oxalate crystallization. Indian Journal of Pharmaceutical Sciences 72, 340.

Christina AJM, Ashok K, Packialakshmi M, Tobin GC, Preethi J, Murugesh N. 2005. Antilithiatic effect of Asparagus racemosus Willd on ethylene glycol-induced lithiasis in male albino Wistar rats. Methods and Findings in Experimental and Clinical Pharmacology 27, 633–638.

Du H, Lei Y,  Gao AN,  Sun XM, Song R,  Yu XD, Deng S, Si HM, Chen J. 2020. Traditional Chinese medicine combined with conventional therapy for female kidney stone: A protocol for systematic review. National Library of Medicine 99(13), 19611.

Gadge N, Jalalpure SS. 2012. Curative treatment with extracts of Bombax ceiba fruit reduces risk of calcium oxalate urolithiasis in rats. Pharmaceutical Biology 50, 310–317.

Harsoliya MS, Pathan JK, Khan N, Bhat D, Patel VM. 2011. Effect of ethanolic extracts of Bergenia ligulata, Nigella sativa and combination on calcium oxalate urolithiasis in rats. International Journal of Drug Formulation and Research 2, 268–280.

Heller HJ, Sakhaee K, Moe OW, Pak CYC. 2002. Etiological role of estrogen status in renal stone formation. The Journal of urology 168, 1923-1927.

Hussain M, Lal M, Ali B. 1998. Urolithiasis in Sindh: a single centre experience with a review of 10,000 cases. Journal of Nephrology Urology and Transplant 1, 10-13.

Jarald E, Joshi S, Jain D. 2008. Antidiabetic activity of aqueous extract and non-polysaccharide fraction of Cynodon dactylon Pers. Indian Journal of Experimental Biology 46, 660–667.

Khan A, Bashir S, Khan SR, Gilani AH. 2011. Antiurolithic activity of Origanum vulgare is mediated through multiple pathways. BMC Complementary and Alternative Medicine 11, 96–99.

Moser CO. 2012. Gender planning and development: Theory, practice and training, Routledge.

Mukherjee AK. 2014. Human kidney stone analysis using X-ray powder diffraction. Journal of the Indian Institute of Science 94, 35-44.

Orlando, M, Kuplich L, de Souza DO, Belich H. 2012. Study of calcium oxalate monohydrate of kidney stones by X-ray diffraction. Cambridge University Press 23(S1), S59-S64.

Prachi Chauhan N, Kumar D, Kasana MS. 2009. Medicinal plants of Muzaffarnagar district used in treatment of Urinary tract and Kidney stones. Indian Journal of Traditional Knowledge 8, 191–195.

Rizvi SAH, Manzoor K. 2002. Causes of chronic renal failure in Pakistan: a single large center experience. Saudi journal of kidney diseases and transplantation 13, 376.

Saltzman JR, Russell RM. 1998. The aging gut: Nutritional issues. Gastroenterology Clinics of North America 27(2), 309-324.

Singh RG, Behura SK, Kumar R. 2010 Litholytic property of Kulattha (Dolichous biflorus) vs potassium citrate in renal calculus disease: A comparative study. The Journal of the Association of Physicians of India 58, 286–289.

Soundararajan P, Mahesh R, Ramesh T, Begum VH. 2006. Effect of Aerva lanata on calcium oxalate urolithiasis in rats. Indian Journal of Experimental Biology 44, 981-986.

Taylor E, Curhan G. 2006. Diet and fluid prescription in stone disease. Kidney international 70, 835-839.

Yaqub MS, Basher B, Aslam R. 2020. Secondary metabolites of the genus Crotalaria (Rattlepods) and their medicinal importance – A Review. Journal of Horticultural Science and Technology 3, 1-7.

Zargooshi J. 2001. Open stone surgery in children: is it justified in the era of minimally invasive therapies. BJU International 88(9), 928-931.