Pseudomonas aeruginosa as a pathogenic Organism

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Review Paper 01/04/2019
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Pseudomonas aeruginosa as a pathogenic Organism

Sidra Mengal, Saima Azam, Muhammad Kamran Taj, Fazal ur Rehman, Umbreen Zafar, Ajmal Nisar Mengal, Ashiq Hussain, Imran Taj, Zohra Samreen, Farooq Shahzad, Hasina wali, Syeda Ayesha Ali, Syeda Hafsa Ali
Int. J. Biosci.14( 4), 286-291, April 2019.
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Pseudomonas aeruginosa, is a member of the Pseudomonadaceae family. Pseudomonas aeruginosa is an opportunistic pathogen commonly found in the environment mainly in soil and water, but is also regularly found on plants and sometimes on animals, including humans. Pseudomonas aeruginosa is an important pathogen in healthcare-associated infections. Pseudomonas aeruginosa cause a variety of infections such as chronic CF lung infection, acute septicemia, wound infection, urinary tract infection, corneal ulceration, endocarditis, and pneumonia. P. aeruginosa also has a large number of virulence factors such as adhesions exotoxin A, exoenzyme S, nan 1 and Las genes, Mucoid exopolysaccharide, Protease enzymes, Lipopolysaccharide, Pigments eg. pyocyanin, 1-hydroxyphenazine, pyoverdin, Phospholipase C, Rhamnolipid, Pili, Lipase, Histamine, and Leukocidin. During pathogenesis P. aeruginosa quorum sensing plays a critical role for survival and colonization by coordinating phenotypic alterations at early stages of infection. Pseudomonas skin and soft tissue infections can be destructive and can cause massive necrosis and gangrene. Pseudomonas aeruginosa is resistant to quinolones, tetracycline, chloramphenicol while It is sensitive to gentamicin. This information about Pseudomonas aeruginosa will help to a better understanding of infectious processes and will allow to develop new effective procedure for prevention and clinical treatment.


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