Quantitative analysis and systematic review of the traditional plants used by Sama Tribe of Simunul Island, Tawi-Tawi, Philippines

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Research Paper 14/07/2023
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Quantitative analysis and systematic review of the traditional plants used by Sama Tribe of Simunul Island, Tawi-Tawi, Philippines

Clarito F. Concepcion, Mae-Hada J. Sali, Al-Fayed P. Sudaria, Angelika L. Lim
J. Bio. Env. Sci.23( 1), 109-135, July 2023.
Certificate: JBES 2023 [Generate Certificate]

Abstract

This ethnobotanical study documents the medicinal plants that are utilized by the Sama tribe of the Simunul, Tawi-Tawi. It aimed to establish the quantitative analysis and systematic review of the ethno medicinal practices of the Sama Simunul, Tawi-Tawi. Snowball sampling was utilized as the sampling method and descriptive research design was utilized. Interviews and semi-structured questionnaires were translated into the Sama dialect. This was utilized in gathering the data from the 50 Sama healers residing at Simunul, Tawi-Tawi, and which majority of them were female. The collection and identification of plants, plants were pressed and mounted using the herbarium techniques, and the validation of the identified plant species was verified after. The systematic review was utilized to determine the active bio-isolates and bioactivities of the medicinal plants that are utilized by the Sama healers. Use-category, use-report, use value, informant consensus factor, and fidelity level were used for the quantitative ethno medicinal analysis. Forty-seven (47) medicinal plants were cited by the respondents and thirty (30) families were identified. Lamiaceae is the most widely used plant family by the Sama healers due to its medicinal constituents, which include a strong aromatic essential oil, tannins, saponins, and organic acids. The leaves were the most used for treatment. In terms of preparation, decoction was commonly used, and it was taken orally.

VIEWS 165

Abe R, Ohtani K. 2013. An ethnobotanical study of medicinal plants and traditional therapies on Batan Island, the Philippines. Journal of ethnopharmacology [Internet]. 145(2), 554-565. Available from https:// doi.org /10.1016/j.jep.2012.11.029

Albuquerque UP, Lucena RFP, Monteiro JM, Florentino ATN, Almeida C, de FCBR. 2006. Evaluating Two Quantitative Ethnobotanical Techniques. Ethnobotany Research and Applications [Internet] 4, 051-060. Available from: https:// ethnobotanyjournal.org/index.php/era/article/view/

Abdelgadir HA, Van Staden J. 2013. Ethnobotany, ethnopharmacology and toxicity of Jatropha curcas L. (Euphorbiaceae): A review. South African Journal of Botany. [Internet] 88, 204-218.

Abu-Irmaileh BE, Afifi FU. 2003. Herbal medicine in Jordan with special emphasis on commonly used herbs. J Ethnopharmacol [Internet] 89, 193-7. Available from https://doi.org/ 10.1016/s0378-8741(03)00283-6.

Aharaja MA, Estepa IIN, Saavedra M. 2022. Quantitative Ethnobotanical Study and Systematic Review of Plants Used by the Sama Bangingi in Tumalutab Island, Zamboanga City. May.

Ahmad M, Sultana S, Fazl-I-Hadi S, Ben Hadda T, Rashid S, Zafar M, Khan MA, Khan MP, Yaseen G. 2014. An ethnobotanical study of medicinal plants in high mountainous region of Chail valley (District Swat- Pakistan). Journal of ethnobiology and ethnomedicine [Internet] 10, 36. Available from: https://doi.org/10.1186/1746-4269-10-36

Alebie G, Urga B, Worku A. 2017. Systematic review on traditional medicinal plants used for the treatment of malaria in Ethiopia: trends and perspectives. Malaria journal [Internet] 16(1), 307. Available from: https://doi.org/10.1186/s12936-017-1953-2

Alhassan AM, Ahmed QU. 2016; Averrhoa bilimbi Linn.: A review of its ethnomedicinal uses, phytochemistry, and pharmacology. J Pharm Bioallied Sci. [Internet] 8(4), 265-271. Available from: DOI: 10.4103/0975-7406.199342.

Aminah S, Wantini S. 2020. The Effect of Basil (Ocimum X Africanum L.) Extract on The Growth of Microbes in the Hand. International Journal of Innovation, Creativity and Change [Internet]. Available from: https://www.ijicc.net/images/vol_13 /Iss_2/Part_2/SC16_Aminah_2020_E_R.pdf

Anantaworasakul, P., Hamamoto, H., Sekimizu, K., & Okonogi, S. 2017. In vitro antibacterial activity and in vivo therapeutic effect of Sesbania grandiflora in bacterial infected silkworms. Pharm Biol [Internet] 55(1), 1256-1262. Available from: DOI: 10.1080/13880209.2017.1297467

Bagalkotkar G, Sagineedu SR, Saad MS, Stanslas J. 2016. Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review. Pharmacy and Pharmacology [Internet] 58, 1559-1570. DOI 10.1211/jpp.58.12.0001

Bashir, S., Jabeen, K., Iqbal, S., Javed, S., & Naeemn, A. 2019. Lantana camara: Phytochemical Analysis and Antifungal Prospective. Planta daninha [Internet] 37. Available from: https://doi.org/10.1590 /S0100-83582019370100137

Batiha GES, Magdy Beshbishy A, Wasef L, Elewa YHA, Al-Sagan A, Abd El-Hack M, Taha A, Abd-Elhakim Y, Devkota HP. 2020. Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review. Nutrients [Internet]. 12(3), 872. doi: 10.3390/nu12030872.

Belgica THR, Suba MD, Alejandro CJD. 2021. Quantitative ethnobotanical study of medicinal flora used by local inhabitants in selected Barangay of Malinao, Albay, Philippines. Biodiversitas [Internet] 22, 2711-2721. Available from: https://doi.org /10.13057/biodiv/d220720

Bhuyan, B., & Sonowal, R. 2021. An Overview of Pandanus Amaryllifolius Roxb.Exlindl. And Its Potential Impact on Health. Current Trends in Pharmaceutical Research [Internet]. 8(1), 2582-4783. Https://dibru.ac.in/wp-content/uploads /2021 /09/08-CTPR-Review-BB-06.pdf

Bhuiyan MNI, Chowdhury JU, Begum J. 2009. Chemical components in volatile oil from Blumea balsamifera (L.) DC. Bangladesh Journal of Botany [Internet] 38(1), 107-109.

Bibi F, Abbas Z., Harun N, Perveen B, Bussmann RW. 2022. Indigenous knowledge and quantitative ethnobotany of the Tanawal area, Lesser Western Himalayas, Pakistan. PloS one [Internet] 17(2), e0263604. Available from: https://doi.org /10.1371/journal.pone.0263604

Binumol M, Sajitha T. 2013. Phytochemical and antibacterial activity of Artocarpus heterophyllus Lam. and Artocarpus communis Forst. on Bacillus subtilis and Pseudomonas fluorescens. International Journal of Scientific & Engineering Research [Internet]. 4(9), 1766-1784. Available from: https://www.ijser.org/researchpaper/Phytochemical-and-antibacterial-activity-of-Artocarpus-heterop hyllus-Lam-and-Artocarpus-communis-Forst.pdf

Brahmi F, Iblhoulen Y, Issaadi H. 2022. Ethnobotanical survey of medicinal plants of bejaia localities from algeria to prevent and treat coronavirus (COVID-19) infection shortened title: phytomedicine to manage COVID-19 pandemic. ADV TRADIT MED (ADTM) [internet]. Available from: https://doi.org/10.1007/s13596-022-00649-z

Caunca, Evane & Balinado, Lloyd. 2021. Determination of Use-Value, Informant Consensus Factor, and Fidelity Level of Medicinal Plants Used in Cavite, Philippines. Asian Journal of Biological and Life sciences. [Internet] 10, 443-453.

Chao W, Lin B. 2010. Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian). Chin Med [Internet] 5, 17. Available from: DOI: 10.1186/1749-8546-5-17.

Cho SY, Kim HW, Lee MK, Kim HJ, Kim JB, Choe JS, Lee YM, Jang HH. 2020. Antioxidant and Anti-Inflammatory Activities in Relation to the Flavonoids Composition of Pepper (Capsicum annuum L.). Antioxidants [Internet] 9(10), 986. Available from: https://doi.org/10.3390/antiox9

Cordero CS, Meve U, Alejandro GJD. 2022. Ethnobotanical Documentation of Medicinal Plants Used by the Indigenous Panay Bukidnon in Lambunao, Iloilo, Philippines. Frontiers in pharmacology [Internet] 12, 790567.

Costa FV, Guimarães MFM, Messias MCT. 2021. Gender differences in traditional knowledge of useful plants in a Brazilian community. PLOS ONE [Internet] 16(7), Available.

Dapar MLG, Alejandro GJD. 2020, Ethnobotanical Studies on Indigenous Communities in the Philippines: Current Status, Challenges, Recommendations, and Future Perspectives. Journal of Complementary Medicine Research [Internet] 11(1), 432. Available from: DOI: 10.5455/jcmr.

Dapar MLG, Alejandro GJD, Meve U, Liede-Schumann S. 2020. Quantitative ethno pharmacological documentation and molecular confirmation of medicinal plants used by the Manobo tribe of Agusan del Sur, Philippines. J Ethnobiology Ethnomedicine [Internet] 16, 14. Available from: https://doi.org/10.1186/s13002-020

Dosoky N, Setzer W. 2018. Chemical Composition and Biological Activities of Essential Oils of Curcuma Species.” Nutrients [Internet] 10(9), 1196. DOI: 10.3390/nu10091196

Dubey SD. 2021. Overview on Cucurbita maxima. International Journal of Phytopharmacy [Internet] 2(3), 68-71. Available from: DOI: 10.7439 /ijpp.

Ducusin MB. 2017. Ethnomedicinal Knowledge of Plants among the Indigenous of Santol, La Union, Philippines. Electronic Journal of Biology [Internet] 13(4), 360-82. Available from https://dokumen.tips /documents/ethnomedicinal-knowledge-of-plants-among-the-indigenous-ethnomedicinal-knowled ge.html?page=1

Dulay RM, De Castro ME. 2016. Antibacterial and Antioxidant Activities of Three Citrus Leaves Extracts. Der Pharmacia Lettre [Internet] 8(13), 167-170. https://www.scholarsresearchlibrary.com/articles/antibacterial-and-antioxidant-activities-of-three-citrus-leaves-extracts.pdf?fbclid=IwAR2uCVBAnug 8Q Wlq ZYxFVkierDxLdVWdhzq9UPTzb4sk14r3dcWHoUxl-

Fajardo WT, Cancino LT, Dudang EB, De Vera IA, Pambdi RM, Junio AD. 2018. Ethnobotanical Study of Traditional Medicinal Plants Used By Indigenous Sambal-Bolinao of Pangasinan, Philippines. Journal of Natural and Allied Sciences [Internet]. 1(1). 52-63. Available from: https://www. psurj.org/wp-content/uploads/2018/01/JONAS 00

Gebreyes T, Melesse M. 2016. Determination of informant consensus factor and fidelity level of ethnomedicinal plants used in Misha Woreda, Hadiya Zone, Southern Ethiopia. International Journal of Biodiversity and Conservation [Internet] 8(12), 351-364. Available from: https://doi.org/ 10.5897

Gruyal GA, Roasario RD, Palmes ND. 2014. Ethnomedicinal plants used by residents in Northern Surigao del sur, Philippines. Natural products chemistry & research [Internet] 2, 1-5. Available from: DOI: 10.4172/2329-6836.1000140

Hui CK, Majid NI, Yusof HM, Zainol KM, Mohamad H, Zin ZM. 2020. Catechin profile and hypolipidemic activity of Morinda citrifolia leaf water extract. Heliyon [Internet] 6(6), e04337. Available from: https://doi.org/10.1016/j.heliyon.2020.e04337

Jadid N, Kurniawan E, Himayani CES, Andriyani, Prasetyowati I, Purwani KI, Muslihatin W, Hidayati D, Tjahjaningrum ITD. 2020. An ethnobotanical study of medicinal plants used by the Tengger tribe in Ngadisari village, Indonesia. PLoS One [Internet]. [cited 2020 Jul 13] 15(7). e0235886. Available from: DOI: 10.1371 /journal.pone.0235886.

Jantan I, Ahmad W, Bukhari SN. 2016; Tinospora crispa (L.) Hook. f. & Thomson: a review of its ethnobotanical, phytochemical, and pharmacological aspects.” Frontiers in pharmacology [Internet] 7, 59. Available from: DOI: 10.3389 /fphar.2016.00059

Joseph B, Jini D. 2013. Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian Pac J Trop Dis [Internet] 3(2), 93-102.

Kafle A, Mohapatra SS, Reddy I, Chapagain M. 2018. A review on medicinal properties of Psidium Guajava. Journal of Medicinal Plants Studies [Internet] 6(4), 44-47. Available from: https://www.plantsjournal.com/archives/2018/vol6issue4/PartA/6-4-11-994.pdf

Kartika IGAA, Insanu M, Safitri D, Putri CA, Adnyana IK. 2016. New update: Traditional uses, phytochemical, pharmacological and toxicity review of Peperomia pellucida (L.) Kunth. Pharmacology OnLine [Internet] 31, 30-43. Available from: https://pharmacologyonline.silae.it/files/newsletter/2016/vol2/PhOL_2016_2_N005_Kartika_30_43.pd

Khan I, Abd Elsalam NM, Fouad H, Tariq A, Ullah R, Adnan M. 2014. Application of Ethnobotanical Indices on the Use of Traditional Medicines against Common Diseases. Evidence-based complementary and alternative medicine [Internet]. [cited 2014 Apr 24]; 2014, 21. Available from: https://doi.org/10.1155/2014/635371

Kondratev VM, Osipova GS, Kiselev MV. 2022. Growth and development of tomato (Lycopersicon esculentum Mill.) under light culture conditions. Earth and Environmental Science [Internet] 1010, 012071.

Krishnaiah D, Devi T, Bono A, Sarbatly R. 2009. Studies on phytochemical constituents of six Malaysian medicinal plants. Journal of Medicinal Plants Research [Internet] 3(2), 067-072.

Kumar BR, Anupam A, Manchikanti P, Rameshbabu AP, Dasgupta S, Dhara S. 2018. “Identification and characterization of bioactive phenolic constituents, anti-proliferative, and anti-angiogenic activity of stem extracts of Basella alba and rubra.” J Food Sci Technol [Internet] 55(5), 1675-1684.

Kumar S, Malhorata R, Kumar D. 2010, Euphorbia hirta: Its chemistry, traditional and medicinal uses, and pharmacological activities. Pharmacogn Rev [Internet] 4(7), 58-61. Available from: DOI: 10.4103/0973-7847.65327

Lasco G, Mendoza J, Renedo A, Seguin ML, Palafox B, Palileo-Villanueva LM, Amit AML, Dans AL, Balabanova D, mc Kee M. 2020. Nasa dugo (‘It’s in the blood’): lay conceptions of hypertension in the Philippines. BMJ global health [Internet] 5(7), e002295. Available from: https://doi.org/10.1136/bmjgh-2020-002295

Lima EB, Sousa CN, Meneses LN, Ximenes NC, Santos Júnior MA, Vasconcelos GS, Lima NB, Patrocínio MC, Macedo D, Vasconcelos SM. 2015. Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review. Braz J Med Biol Res [Internet] 48(11), 953-64. Available from: DOI: 10.1590/1414-431X20154773.

Ly HT, Pham Nguyen MT, Nguyen TKO, Bui TPQ, Ke X, Le VM. 2020. Phytochemical analysis and wound-healing activity of noni (Morinda citrifolia) leaf extract. Journal of Herbs, Spices & Medicinal Plants [Internet] 26(4), 379-393. Available from: https://doi.org/10.1080/10496475.

Madjos G, Ramos K. 2021. Ethnobotany, Systematic Review and Field Mapping on Folkloric Medicinal Plants in the Zamboanga Peninsula, Mindanao, Philippines. Journal of Complementary Medicine Research [Internet]. Available from DOI: 10.5455/jcmr.2021.12.01.05.

Mahomoodally MF, Sadeer NB, Suroowan S, Jugreet S, Lobine D, Rengasamy KRR. 2020. Ethnomedicinal, phytochemistry, toxicity and pharmacological benefits of poison bulb – Crinum asiaticum L. South African Journal of Botany [Internet] 136, 16-29. Available from: https://doi.org /10.1016/j.sajb.2020.06.004

Mao QQ, Xu XY, Cao SY, Gan RY, Corke H, Beta T, Li HB. 2019. Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe). Foods [Internet]. 8(6), 185. Available from: DOI: 10.3390/foods8060185.

Masendo A. 2015. The Manobo Tribe Then and Now: An Ethnography. International Journal of Scientific & Engineering Research [Internet] 6(4), 227. Available from: https://www.ijser.org/paper /The-Manobo-Tribe-Then-and-Now-An-Ethnography

Mohiuddin AK. 2019. Medicinal and Therapeutic values of Sesbania grandiflora. Journal of Pharmacology and Clinical trials [Internet] 19(1), Available from: https://norcaloa.com/journals/JPCT-

Mun’im A, Puteri MU, Sari SP. 2016. Azizahwati. Anti-anemia effect of standardized extract of moringa oleifera lamk. Leaves on aniline induced rats. Pharmacognosy Journal [Internet] 8(3), 255-258. Available from: https://doi.org/10.5530/pj.2016.3.14

Nalimu F, Oloro J, Kahwa I, Ogwang PE. 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Futur J Pharm Sci [Internet] 7(1), 145. Available from: DOI: 10.1186/s43094-021-00296-2.

Nguyen LTT, Nguyen TT, Nguyen HN, Bui QTP. 2020. Simultaneous determination of active compounds in Piper betle Linn. leaf extract and effect of extracting solvents on bioactivity. Engineering Reports [Internet] 2(10). Available from: https:// doi.org/10.1002/eng2.12246

Niu Y, Wang S, Li C, Wang J, Liu Z, Kang W. 2020. Effective Compounds From Caesalpinia sappan L. on the Tyrosinase In Vitro and In Vivo. Natural Product Communications [Internet] 15(4), Available from: DOI: 10.1177/1934578X20920055

Nuneza OM, rodriguez BC, Nasiad JM. 2021, View of ethnobotanical survey of medicinal plants used by the mamanwa tribe of surigao del norte and agusan del norte, mindanao, philippines. Smujo. https: //smujo.id/biodiv/article/view/7703/4884

Nwokocha CR, Owu DU, Gordon A, Thaxter K, mcCalla G, Ozulua RI, Young L. 2012. Possible mechanisms of action of the hypotensive effect of Annona muricata (soursop) in normotensive Sprague–Dawley rats, Pharmaceutical Biology [Internet]. 50(11), 1436-1441, DOI: 10.3109/13 880209.2012.684690

Nzimande S, Moshabela M, Zuma T, Street R, Ranheim A, Falkenberg T. 2021. Barriers and facilitators of traditional health practitioners’ regulation requirements: a qualitative study. Journal of Global Health Reports. Available from: https://www.joghr.org/article/21402-barriers-and-

Obidoa O, Joshua PE, Eze N. 2009. Phytochemical Analyses of Cocos Nucifera L. Journal of Pharmacy Research [Internet] 1(1), 87-96. Available from: https://www.researchgate.net /publication /41187192_Phytochemical_ Analysis _of_ Cocos _nucifera_L?fbclid=IwAR1F37ffxiP4g81 UNlyaJz67LDn0IZ6EXA1UyQASaG9FYe60gx7xmrcG

Obregón-Díaz Y, Pérez-Colmenares A, Obregón-Alarcón K, Aparicio-Zambrano R, Rojas-Fermin L, Usubillaga A, Carmona J. 2019. Volatile Constituents of the Leaves of Kalanchoe pinnata From the Venezuelan Andes. Natural Product Communications [Internet] 14(5), Available from: DOI: 10.1177/1934578X19842703

Odebunmi CA, Adetunji TL, Adetunji AE, Olatunde A, Oluwole OE, Adewale IA, Ejiwumi AO, Iheme CE, Aremu TO. 2022. Ethnobotanical Survey of Medicinal Plants Used in the Treatment of COVID-19 and Related Respiratory Infections in Ogbomosho South and North Local Government Areas, Oyo State, Nigeria. Plants [Internet] 11, 2667. Available from: https://doi.org/10.3390

Olaniyan O, Ajayi EI. 2021. Phytochemicals and in vitro anti-apoptotic properties of ethanol and hot water extracts of Cassava (Manihot esculenta Crantz) peel biogas slurry following anaerobic degradation. Clin Phytosci [Internet] 7, 77. Available from: https://doi.org/10.1186/s40816-021-00311-2

Olatunji TL, Afolayan AJ. 2019. Comparative Quantitative Study on Phytochemical Contents and Antioxidant Activities of Capsicum annuum L. and Capsicum frutescens L. The Scientific World Journal [Internet] 4705140, 13. Available from: https:// doi.org/10.1155/2019/4705140

Olowa L, Demayo CG. 2015. Ethnobotanical uses of medicinal plants among the Muslim Maranaos in Iligan City, Mindanao, Philippines. Advances in Environmental Biology [Internet] 9(27), 204+. Available from https://link.gale.com/apps/doc/ A444400790/AONE?u=anon~c496140a&sid= googleScholar& xid=5127a5f4

Ong HG, Kim YD. 2014. Quantitative ethnobotanical study of the medicinal plants used by the Ati Negrito indigenous group in Guimaras island, Philippines. Journal of ethnopharmacology [Internet] 157, 228-242. Available from: https://doi.org /10.1016/j.jep.2 014.09.015

Oniga I, Pușcaș C, Silaghi-Dumitrescu R, Olah NK, Sevastre B, Marica R, Marcus I, Sevastre-Berghian AC, Benedec D, Pop CE, Hanganu D. 2018. Origanum vulgare ssp. vulgare: Chemical Composition and Biological Studies. Molecules [Internet]. 23(8), 2077. Available from: DOI: 10.3390/molecules23082077.

Panda SK, Thatoi HN, Dutta SK. 2009. Antibacterial activity and phytochemical screening of leaf and bark extracts of Vitex negundo l. from similipal biosphere reserve, Orissa. Journal of Medicinal Plants Research [Internet] 3(4), 294-300. Available from: https://www.researchgate.net /publication/228482464

Pandy V, Narasingam M, Kunasegaran T, Murugan DD, Mohamed Z. 2014. Effect of noni (Morinda citrifolia Linn.) fruit and its bioactive principles scopoletin and rutin on rat vas deferens contractility: an ex vivo study. Scientific World Journal [Internet] 909586. Available from: DOI: 10.1155/2014/909586.

Park S, Nam YH, Rodriguez I, Park JH, Kwak HJ, Oh Y, Oh M, Park MS, Lee KW, Lee JS, Kim DH, Park YH, Moon IS, Choung SY, Jeong KW, Hong BN, Kang TH, Kim SH. 2019. Chemical constituents of leaves of Persea americana (avocado) and their protective effects against neomycin-induced hair cell damage. Revista Brasileira de Farmacognosia [Internet] 29(6), 739-743. Available from: https://doi.org/10.1016 /j.bjp .2019.08.004

Paval J, Kaitheri SK, Potu BK, Govindan S, Kumar RS, Narayanan SN, Moorkoth S. 2009. Anti-arthritic potential of the plant Justicia gendarussa Burm F. Clinics (Sao Paulo, Brazil) 64(4), 357-362. https://doi.org/10.1590/s1807-59322 009000400015

Pucot J, Manting MM, Demayo C. 2019. Ethnobotanical Plants Used by Selected Indigenous Peoples Of Mindanao, The Philippines As Cancer Therapeutics. Pharmacophore [Internet] 10, 61-69. Available from: https://www.researchgate.net/ publication/344537304

Raja R. 2012. Medicinally Potential Plants of Labiatae (Lamiaceae) Family: An Overview. Research Journal of Medicinal Plant. [Internet] 6, 203-213. Availabe from: DOI: 10.3923/rjmp.2012.203.213.

Raj A, Menon V, Sharma N. 2020. Phytochemical screening, antimicrobial, antioxidant and cytotoxic potential of different extracts of Psidium guajava leaves. Vegetos [Internet] 33(4), 750-758. Available from: https://doi.org/10.1007/s42535-020-00151-4

Reddy NM. 2013. Lantana Camara Linn. Chemical Constituents and Medicinal Properties: A Review. Sch. Acad. J. Pharm [Internet] 2(6), 445-448. Available from: https://saspublishers.com/media /articles/SAJP26445-448.pdf

Rigat M, Vallès J, D’Ambrosio U, Gras A, Iglésias J, Garnatje T. 2015. Plants with topical uses in the Ripollès district (Pyrenees, Catalonia, Iberian Peninsula): ethnobotanical survey and pharmacological validation in the literature. Journal of ethnopharmacology. [Internet] 164, 162-179. Available from: https://doi.org/10.1016/j.jep. 2015.

Rivero AG, Keutgen A, Pawelzik E. 2022. Antioxidant Properties of Tomato Fruit (Lycopersicon esculentum Mill.) as Affected by Cultivar and Processing Method. Horticulturae [Internet]. 8, 547.

Saadullah M, Asif M, Arif S, Kanwal BA. 2022. Comprehensive Review on Traditional Uses, Chemical Constituents, and Diverse Pharmacological Importance of the Genus Breynia. Record of Natural Products [Internet] 6, 538-549. Available from: http://doi.org/10.25135/rnp.314.2112.2280

Sari TA, Chandra B, Rivai H. 2021. Overview of Traditional Use, Phytochemical and Pharmacological Activities of Cucumber (Cucumis sativus L.). Int. Journal of Pharmaceutical Sciences and Medicine [Internet] 6(3), 39-49. Available from: DOI: 10.47760/ijpsm. 2021.v06i03.004

Shah G, Shri R, Panchal V, Sharma N, Singh B, Mann AS. 2011. Scientific basis for the therapeutic use of Cymbopogon citratus, stapf (Lemon grass). J Adv Pharm Technol Res [Internet] 2(1), 3-8. Available from: DOI: 10.4103/2231-4040.79796

Sharma A, Bachheti A, Sharma P, Bachheti RK, Husen A. 2020; Phytochemistry, pharmacological activities, nanoparticle fabrication, commercial products and waste utilization of Carica papaya L.: A comprehensive review. Current Research in Biotechnology [Internet] 2, 145-160. https://doi.org/10.1016/j.crbiot.2020.11.001

Shekarchi M, Hajimehdipoor H, Saeidnia S, Gohari AR, Hamedani MP. 2012.. Comparative study of rosmarinic acid content in some plants of Labiatae family. Pharmacognosy magazine. [Internet]. 8(29), 37-41. Avialbe from: https:// doi.org /10.4103/0973-1296.93316

Shirur SD, Roshan A, Timilsima SS, Sunita S. 2013. A review on the medicinal plant psidium guajava linn. (myrtaceae). Journal of Drug Delivery & Therapeutics [Internet]. 3(2), 162-168. Available from: https://doi.org/10.22270/jddt.v3i2.404

Singh S, Shankar R, Singh GP. 2017. Prevalence and Associated Risk Factors of Hypertension: A Cross-Sectional Study in Urban Varanasi, International Journal of Hypertension [Internet]. vol. 2017, Article ID 5491838, 10 pages. Available from: https://doi.org/10.1155/2017/5491838

Sun Q, Shen YH, Tian JM, Tang J, Su J, Liu RH, Li HL, Xu XK, Zhang WD. 2009. Chemical constituents of Crinum asiaticum L. var. sinicum Baker and their cytotoxic activities. Chem Biodivers [Internet] 6(10), 1751-7. Available from: DOI: 10.1002/cbdv.200800273.

Sukor S, Zahari Z, Rahim N, Yusoff J, Salim F. 2022Chemical Constituents and Antiproliferative Activity of Eleusine indica (L.) Gaertn. Sains Malaysiana [Internet].; 51(3), 873-882. Available from: http://doi.org/10.17576/jsm-2022-5103-21

Tantengco OA, Condes ML, Estadilla HH, Ragragio E. 2018. Ethnobotanical Survey of Medicinal Plants used by Ayta Communities in Dinalupihan, Bataan, Philippines. Pharmacognosy Journal [Internet]. 10(5), 859-870. Available from: DOI: 10.5530/pj.2018.5.145

Tugume P, Nyakoojo C. 2019. Ethno-pharmacological survey of herbal remedies used in the treatment of paediatric diseases in Buhunga parish, Rukungiri District, Uganda. BMC Complement Altern Med [Internet] 19, 353. Available from https://doi.org/10.1186/s12906-019-2763-6

Velazquez MDRH, Palmero OR, Cortiñas LT, Pacuar MCV, Faramiñan EB, Macias, L.C. 2016; Traditional use of plants as antihypertensive in Jipijapa, Manabí. Comparison with reported in the literature. Mol2Net [Internet] 2. 1-17. Available from: http://sciforum.net/conference/mol2net-02

Vergara-Jimenez M, Almatrafi MM, Fernandez ML. 2017;Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease. Antioxidants (Basel) [Internet] 6(4). 91. Available from: DOI: 10.3390/antiox6040091.

Wirata N, Gede Agung AA, Arini NW, Nuratni NK. 2021Sentul Fruit (Sandoricum koetjape) Peel as Anti-Inflammation for Gingivitis after Scaling. Journal of Health and Medical Sciences [Internet] 4(4). 27-36. Available from: DOI: 10.31014/aior. 1994.04.04.190

Yanto TA, Hatta M, Bukhari A, Natzir R. 2020; Molecular and Immunological Mechanisms of Miana Leaf (Coleus Scutellariodes [L] Benth) in Infectious Diseases. Biomed Pharmacol J [Internet]. 13(4). Available from: https://bit.ly/3nojGwU

Yimam M, Yimer SM, Beressa TB. 2022;Ethnobotanical study of medicinal plants used in Artuma Fursi district, Amhara Regional State, Ethiopia. Tropical medicine and health [Internet] 50(1), 85. Available from: https://doi.org /10.1186 /s41182-022-00438-z

Zhao X, Lin FJ, Li H, Li HB, Wu DT, Geng F, Ma W, Wang Y, Miao BH, Gan RY. 2021. Recent Advances in Bioactive Compounds, Health Functions, and Safety Concerns of Onion (Allium cepa L.). Frontiers in Nutrition [Internet]. Available from: https://doi.org/10.3389/fnut.2021.669805