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Quorum sensing inhibitors: a tool for resistance against biofilm

Research Paper | December 1, 2019

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Muhammad Asif Rafiq, Muhammad Shahid, Muhammad Atiq, Shahid Ali Chand, Muhammad Nauman Gulzar, Muhammad Ammar, Shahbaz Akhtar, Kashif Irshad

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Int. J. Biosci.15( 6), 51-62, December 2019

DOI: http://dx.doi.org/10.12692/ijb/15.6.51-62


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Resistance among disease causing microorganism has increased, which inspire researchers to discover new antimicrobial drugs. In the field of medicine many researches have been conducted to find novel structures for the manufacturing of antimicrobial agents. Various biologically active compounds from plant have antimicrobial properties. Their ability is due to their anti-virulence characteristics. Quorum sensing is cell talking or communication mechanism in microbes which is based on microbial cell density and direct the virulence of many microbes by expressing certain genes. Quorum sensing has become an interesting goal for the manufacturing of new anti-virulent agents that do not depend on usage of antibiotics. Compounds which inhibit quorum sensing have the power to control development of disease. Medicinal plants, give us range of biological active compounds which control the disease process. These compounds are recently being studied to be an effective Quorum sensing inhibitors. So, the purpose of this review is to give a brief description of articles on plant and natural compounds with quorum sensing inhibitory effects.


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Quorum sensing inhibitors: a tool for resistance against biofilm

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