Recent trends in typhoid research- A Review

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Research Paper 01/03/2012
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Recent trends in typhoid research- A Review

Kishwar Hayat Khan
Int. J. Biosci.2( 3), 110-120, March 2012.
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Typhoid fever is an infectious disease caused by salmonella enterica serotype typhi. It is a disease of global distribution. In India and Bangladesh, the highest incidence has been observed among children aged less than five years, while in Vietnam, the peak incidence has been found to occur in children in between five to nine years. Prevention is the present requirement for the people of this young age group. This article is totally based on literature survey and is the updated work of the published review article of the corresponding author. This article discusses and summarizes important work in literature in response to the epidemiology, symptoms and diagnosis of typhoid. Much stress has been given to salmonella and immune system and study was done on infection of salmonella to various organs. Genes involved during infection and typhoid related to nanotechnology was also described in detail. In this communication the authors reviewed the vaccination used against typhoid fever. Much focused has been given for the plants products and herbal drugs to minimize pathogenicity caused by salmonellae. This article will be very helpful for those researchers working in the field of infectious diseases caused by salmonellae species.


Abdoel TH, Pastoor R, Smits HL, Hatta M. 2007. Laboratory evaluation of a simple and rapid latex agglutination assay for the serodiagnosis of typhoid fever. Trans R Soc Trop Med Hyg 101(10), 1032-1038.

Akinyemi KO, Mendie UE, Smith ST, Oyefolu AO, Coker AO. 2005a. Screening of some medicinal plants used in south-west Nigerian traditional medicine for anti-Salmonella typhi activity. J Herb Pharmacother 5(1), 45-60.

Akinyemi KO, Smith SI, Bola Oyefolu AO, Coker AO. 2005b. Multidrug resistance in Salmonella enterica serovar typhi isolated from patients with typhoid fever complications in Lagos, Nigeria. Public Health 119 (4), 321-327.

Anthonia O, Olumide O. 2010. In Vitro Antibacterial Potentials and Synergistic Effect of South- Western Nigerian Plant Parts Used in Folklore Remedy for Salmonella typhi infection. Nature and Science 8(9), 52-59.

Bajracharya BL, Baral MR, Shakya S, Tuladhar P, Paudel M, Acharya B. 2006. Clinical profile and antibiotics response in typhoid fever. Kathmandu Univ Med J 4 (1), 25-29.

Chowdhury AN, Azam MS, Aktaruzzaman M, Rahim A. 2009. Oxidative and antibacterial activity of Mn3O4. J Hazard Mater 172(2-3), 1229-1235.

Chowta MN, Chowta NK. 2005. Study of Clinical Profile And Antibiotic Response In Typhoid Fever. Indian J Med Microbiol 23(2), 125-127.

Clark TW, Daneshvar C, Pareek M, Perera N, Stephenson I. 2010. Enteric fever in a UK regional infectious diseases unit: A 10 year retrospective review. J Infect 60 (2), 91-98.

Cook J, Jeuland M, Whittington D, Poulos C, Clemens J, Sur D, Anh DD, Agtini M, Bhutta Z. 2008. The cost-effectiveness of typhoid Vi vaccination programs: Calculations for four urban sites in four Asian countries. Vaccine 26 (50), 6305-3616.

Crawford RW, Rosales RR, Ramírez-Aguilar Mde L, Chapa AO, Alpuche AC, Gunn GS. 2010. Gallstones play a significant role in Salmonella spp. gallbladder colonization and carriage. Proc Natl Acad Sci U S A 107(9), 4353-4358.

Daigle F. 2008. Typhi genes expressed during infection or involved in pathogenesis. J Infect Dev Ctries 2(6), 431-437.

D’Cruz S, Kochhar S, Chauhan S, Gupta V. 2009. Isolation of Salmonella paratyphi A from renal abscess. Indian J Pathol Microbiol 52(1), 117-119.

Dong BQ, Yang J, Wang XY, Gong J, Seidlein, L.von, Wang ML, Lin M, Liao HZ, Ochiai RL, Xu ZY, Jodar L, Clemens JD. 2010. Trends and disease burden of enteric fever in Guangxi province, China, 1994-2004. Bull World Health Organ 88 (9), 689-696.

Dutta S, Sur D, Manna B, Sena B, Deba A, Deen JL, Wainc J, Seidlein LV, Ochiai L, Clemens JD, Bhattacharya S. 2006. Evaluation of new-generation serologic tests for the diagnosis of typhoid fever: data from a community-based surveillance in Calcutta, India. Diagn Microbiol Infect Dis 56 (4), 359-365.

Fae Farrer. 2010. Antibiotic Prescriptions. SA Pharmaceutical Journal 77 (3), 17-24.

Faucher SP, Porwollik S, Dozois CM, McClelland M, Daigle F. 2006. Transcriptome of Salmonella enterica serovar Typhi within macrophages revealed through the selective capture of transcribed sequences. Proc Natl Acad Sci U S A. 103(6), 1906-1911.

Forest CG, Ferraro E, Sabbagh SC, Daigle F. 2010. Intracellular survival of Salmonella enterica serovar Typhi in human macrophages is independent of Salmonella pathogenicity island (SPI)-2. Microbiology. 156(Pt 12), 3689-3698.

Fraser A, Paul M, Goldberg E, Acosta CJ, Leibovici L. 2007. Typhoid fever vaccines: Systematic review and meta-analysis of randomised controlled trials. Vaccine 25(45), 7848-7857.

Gowri SS, Vasantha K. 2010. Phytochemical Screening and Antibacterial Activity of Syzygium cumini (L.) (Myrtaceae) Leaves Extracts. International Journal of PharmTech Research 2 (2), 1569-1573.

Guzman CA, Borsutzky S, Griot-Wenk M, Metcalfe IC, Pearman J, Collioud A. 2006. Didier Favre and Guido Dietrich, Vaccines against typhoid fever. Vaccine 24 (18), 3804-3811.

Holt KE, Dolecek C, Chau TT, Duy PT, La TT, Hoang NV, Nga TV, Campbell JI, Manh BH, Vinu Chau NV, Hien TT, Farrar J, Dougan G, Baker S. 2011. Temporal fluctuation of multidrug resistant salmonella typhi haplotypes in the mekong river delta region of Vietnam. PLoS Negl Trop Dis 5 (1), e929.

Jackson AA, Ismail A, Ibrahim TA, Kadar ZS, Nawi NM. 1995. Retrospective review of dot enzyme immunoassay test for typhoid fever in an endemic area. Sotheast Asian J Trop Med Public Health 26(4), 625-630.

Jhawar M, George P, Pawar B. 2010. Salmonella typhi sepsis and rhabdomyolysis with acute renal failure: a rare presentation of a common disease. Saudi J Kidney Dis Transpl 21(4), 732-734.

Khan KH. 2010a. Emblica officinalis Reduces the Initiation of Oxidative Stress by Salmonella typhimurium in Mice and Can be Used in Typhoid. Lat. Am. J. Pharm 29 (2), 171-177.

Khan KH. 2010b. Protective effect of Emblica officinalis against S.typhimurium through its antioxidant activity. Recent Research in Science and Technology 2(4), 29-36.

Khan KH. 2009a. Immunomodulatory activity of Terminalia chebula against Salmonella typhimurium in mice. Recent Research in Science and Technologies 1(5), 211-216.

Khan KH. 2009b. The effect of regular intake of Terminalia chebula on oxidative stress in mice originated from Salmonella typhimurium. Eur Asia J Bio Sci 3 (15), 113-121.

Khan KH. 2009c. Terminalia chebula reduces the oxidative stress induced by salmonella typhimurium in mice and may reduce the risk of getting typhoid. Advances in Biological Research 3 (1-2), 1-8.

Khan KH, Ganjewala D, Rao KVB. 2008. Recent advancement in typhoid research- a review. Advanced BioTech 7 (4), 35-41.

Khan KH, Jain SK. 2009. Regular intake of Terminalia chebula can reduce the risk of getting typhoid fever. Advanced Biotech 8(9), 10-15.

Krishnan P, Stalin M, Balasubramanian S. 2009. Changing trends in antimicrobial resistance of Salmonella enterica serovar typhi and salmonella enterica serovar paratyphi A in Chennai. Indian J Pathol Microbiol 52(4), 505-508.

Lauria DT, Maskery B, Poulos C, Whittington D. 2009. An optimization model for reducing typhoid cases in developing countries without increasing public spending. Vaccine 27 (10), 1609-1621.

Lyon CE, Sadigh KS, Carmolli MP, Harro C, Sheldon E, Lindow JC, Larsson CJ, Martinez T, Feller A, Ventrone CH, Sack DA, DeNearing B, Fingar A, Pierce K, Dill EA, Schwartz HI, Beardsworth EE, Kilonzo B, May JP, Lam W, Upton A, Budhram R, Kirkpatrick BD. 2010. In randomized,double-blined,placebo-controlled trial,the single oral dose typhoid vaccine, M01ZH09, is and immunogenic at doses up to 1.7×1010 Colony-forming units.Vaccine 28 (20), 3602-3608.

Mège JL, Mehraj V, Capo C. 2011. Macrophage polarization and bacterial infections. Curr Opin Infect Dis 24(3), 230-234.

Mohammadi G, Valizadeh H, Barzegar-Jalali M, Lotfipour F.,Adibakia K, Milani M, Azhdarzadeh M., Kiafar F., Nokhodchi. A. 2010. Development of azithromycin–PLGA nanoparticles: Physicochemical characterization and antibacterial effect against Salmonella typhi. Colloids Surf B Biointerfaces 80 (1), 34-39.

Musa AD, Yusuf GO, Ojogbane EB, Nwodo OFC. 2010. Screening of Eight Plants Used In Folkloric Medicine for the Treatment of Typhoid Fever. J. Chem. Pharm. Res 2(4), 7-15.

Naheed A, Ram PK, Brooks WA, Hossain MA, Parsons MB, Talukder KA, Mintz E, Luby S, Breiman RF. 2010. Burden of typhoid and paratyphoid fever in a densely populated urban community, Dhaka, Bangladesh. Int J Infect Dis 14(3), 93-99.

Nath G, Gulati AK, Shukla VK. 2010. Role of bacteria in carcinogenesis, with special reference to carcinoma of the gallbladder. World J Gastroenterol 16(43), 5395-5404.

Osifo OD, Ogiemwonyi SO. 2010. Typhoid ileal perforation in children in Benin city. Afr J Paediatr Surg 7(2), 96-100.

Parkhill J, Dougan G, James KD, Thomson NR, Pickard D, Wain J, Churcher C, Mungall KL, Bentley SD, Holden MT, Sebaihia SM, Baker S, Basham D, Brooks K, Chillingworth T, Connerton P, Cronin A, Davis P, Davies RM, Dowd L, White N, Farrar J, Feltwell T, Hamlin N, Haque A, Hien TT, Holroyd S, Jagels K, Krogh A, Larsen TS., Leather S, Moule S, O’Gaora P, Parry C, Quail M, Rutherford K, Simmonds M, Skelton J, Stevens K, Whitehead S, Barrel BG. 2001. Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18. Nature 413 (6858), 848-852.

Pastoor R, Hatta M, Abdoel TH, Smits HL. 2008. Simple, rapid, and affordable point-of-care test for the serodiagnosis of typhoid fever. Diagn Microbiol Infect Dis 61(2), 129-134.

Pinto-Alphandary H, Andremont A, Couvreur P. 2000. Targeted delivery of antibiotics using liposomes and nanoparticles: research and applications-Review. Int J Antimicrob Agents 13 (3), 155-168.

Salazar-González RM, Maldonado-Bernal C, Ram´ırez-Cruz NE, Rios-Sarabia N, Beltrán-Nava J, Castañón-González J, Castillo-Torres N, Palma-Aguirre JA, Carrera-Camargo M, López-Mac´ıas C, Isibasi A. 2004. Induction of cellular immune response and anti-Salmonella enteric serovar typhi bactericidal antibodies in healthy volunteers by immunization with a vaccine candidate against typhoid fever. Immunology Letters 93 (2-3), 115-122.

Schwan W, Huang X, Hu L, Kopecko D. 2000. Differential bacterial survival, replication, and apoptosis-inducing ability of Salmonella serovars within human and murine macrophages. Infect Immun 68 (3), 1005-1013.

Shetty AK, Mital SR, Bahrainwala AH, Khubchandani RP, Kumta NB. 1999. Typhoid hepatitis in children. J Trop Pediatr 45(5), 287-290.

Sulaiman K, Sarwari AR. 2007. Culture-confirmed typhoid fever and pregnancy. Int J Infect Dis 11 (4), 337-341.

Sumathi P, Parvathi A. 2010. Antimicrobial activity of some traditional medicinal plants Journal of Medicinal Plants Research 4 (4), 316-321.

Trivedi ND, Trivedi UN. 2010. Case Report and Pathological Result Based Study On Typhoid Patients. International Journal of Pharmaceutical Sciences Review and Research 2(2), 22-23.

Van Wolfswinkel ME, Lahri H, Wismans PJ, Petit PLC, van Genderen PJJ. 2009. Early small bowel perforation and cochleovestibular impairment as rare complications of typhoid fever. Travel Med Infect Dis 7 (5), 265-268.

Villarreal JM, Hernández-Lucas I, Gil F, Calderón IL, Calva E, Saavedra CP. 2011. The cAMP-Receptor Protein (CRP) positively regulates the yihU-yshA operon in Salmonella enterica serovar Typhi. Microbiology 157(Pt 3), 636-47.

Vinothkumara P, Sivaraja A, Syed ZA, Sivamani P, Devi K, Senthilkumar, B. 2010. Evaluation of antibacterial activities of Andrographis paniculata leaf extract against selective gram positive and gram negative species by in vitro methods. Journal of Pharmacy Research 3(7), 1513-1515.

Wang S, Singh AK, Senapati D, Neely A, Yu H, Ray PC. 2010. Rapid colorimetric identification and targeted photothermal lysis of Salmonella bacteria by using bioconjugated oval-shaped gold nanoparticles. Chemistry 16(19), 5600-5606.

Watson KG, Holden DW. 2010. Dynamics of growth and dissemination of Salmonella in vivo. Cell Microbiol 12(10), 1389-1397.

Widal F. 1896. Serodiagnostique de la fievre typhoide. Bull. Mem. Soc. Med. Hop. Paris 13:561-565.

Yang Y, Chen J, Li H, Wang Y, Xie Z, Wu M, Zhang H, Zhao Z, Chen Q, Fu M, Wu K, Chi C, Wang H, Gao R. 2007. Porcine interleukin-2 gene encapsulated in chitosan nanoparticles enhances immune response of mice to piglet paratyphoid vaccine. Comp Immunol Microbiol Infect Dis. 30(1), 19-32.

Zaki SA, Karande S. 2011. Multidrug-resistant typhoid fever: a review. J Infect Dev Ctries 5(5), 324-337.

Zhou L, Pollard AJ. 2010. A fast and highly sensitive blood culture PCR method for clinical detection of Salmonella enterica serovar Typhi. Ann Clin Microbiol Antimicrob 19, 9:14.