Relationship between leptin and insulin action in adult men

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Research Paper 01/05/2013
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Relationship between leptin and insulin action in adult men

Sokhanguei Yahya
Int. J. Biosci.3( 5), 156-161, May 2013.
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There is considerable evidence that obesity is associated with systemic inflammation, but the underlying mechanisms of these associations are largely unknown. In this study, we evaluate serum leptin in relation to insulin function in obese men. For this purpose, fasting serum level of leptin, insulin and glucose were measured in thirty five non-trained adult men (aged, 35 ± 5.7 years; Body mass index, 32.9 ± 3.4 kg/m2). Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and insulin sensitivity (HOMA-IS) were calculated by the fasting blood glucose and insulin. Pearson correlation method used to determine the relationship between serum leptin with insulin resistance and insulin sensitivity in studied subjects. Data analysis showed that serum leptin was positively related with insulin resistance (p = 0.003, r = 0.50) and negatively related with insulin sensitivity (p = 0.014, r = 0.43) in studied subjects. We conclude that serum leptin measuring can be precise predictor of insulin action in obese individuals.


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