Relationship of anti-inflammatory adiponectin with insulin resistance in smoker

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Research Paper 01/04/2013
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Relationship of anti-inflammatory adiponectin with insulin resistance in smoker

Aghazadeh Javad, Maleki Behnam, Shirvani Hossein, Shahriary Behnam
J. Bio. Env. Sci.3( 4), 89-94, April 2013.
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Accumulating evidence indicates that smokers are at high risk compared to non-smokers for development of diabetes. The objective of this study was to determine relation of serum adiponectin with insulin resistance in cigarette smokers. For this purpose, fasting serum adiponectin, insulin and glucose concentration were measured in 37 healthy adult male smokers after an overnight fast. Insulin resistance was assessed using the homeostasis model assessment for insulin resistance formula derived from fasting insulin and glucose levels. A Pearson correlation was used to establish the relationship between serum adiponectin concentrations with insulin resistance in studied subjects. Although we did not observe any relationship between adiponectin with glucose concentration, but this anti-diabetic cytokine was inversely correlated with insulin resistance in smoker subjects. Based on this observation, we can say that each of insulin resistance or serum adiponectin directly can affect each other.


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