Resistin and homeostasis model assessment insulin resistance index in obese men

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Research Paper 01/02/2014
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Resistin and homeostasis model assessment insulin resistance index in obese men

Aghazadeh Javad, Ghazvineh Mohamadhosein, Maleki Behnam, Shahriary Bahman
J. Bio. Env. Sci.4( 2), 347-352, February 2014.
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Resistin, an adipocyte-derived factor has been shown to be associated with inflammatory conditions, obesity and insulin-resistant rodents and humans. In order to investigate whether serum resistin is different between obese and no obese subject and whether this adipokine is related with insulin resistance in obese individuals. Fasting blood samples were collected in fifteen sedentary healthy obese and thirteen normal weight men matched for age 33 – 41 years. Blood samples were analyzed in order to measuring resistin, insulin and glucose concentrations. The insulin resistance index was assessed by homoeostasis model assessment (HOMA-IR). All subjects were no smoker and no athletes. Statistic analysis was done with SPSS 15.0 for Windows. The data showed that serum resistin in obese group was significantly higher than normal weight men (10.19 +/- 1.82 in obese versus 5.05 +/-1.42 in normal subjects, ng/ml, p<0.001). There were no correlations between resistin concentrations with insulin, insulin resistance and glucose concentration in obese subjects (p ≥ 0.05). These findings suggest a positive relation between obesity and resistin levels independent of insulin resistance in these subjects.


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