Resistin response to a short time cycling in asthma patients

Paper Details

Research Paper 01/06/2012
Views (274) Download (10)

Resistin response to a short time cycling in asthma patients

Ahmadi Pezhman, Torabi Mohsen, Aran Ardabili Akbar, Aghazadeh Javad
J. Bio. Env. Sci.2( 6), 54-59, June 2012.
Certificate: JBES 2012 [Generate Certificate]


The role of peptide hormones in modulating systemic inflammation are of increasing interest and importance in studies of respiratory diseases. The purpose of this study was to compare serum resistin between asthma and those with non-asthma men and also to evaluate its serum resistin response to a single bout cycling in asthma patients. For this purpose, seventeen adult men with asthma and the same number of healthy subjects matched for age and BMI participated in this study by accidentally samples. Respiratory functional markers and Fasting serum resistin were compared in two groups. Then, respiratory functional markers and serum resistin were measured after a single bout cycling in asthma patients. The data were compared by independent-paired T test. At baseline, respiratory functional markers (FEV1, FEV1/FVC) and serum resistin in asthma patients was higher than healthy subjects (p < 0.05). Exercise protocol resulted in an increase in respiratory function and decrease in serum resistin in studied patients (p < 0.05). Based on these data we can say Serum Resistin may be a precise predictor of asthma and one moderate exercise cycling can be improve this inflammation marker these patients.


Al Mutairi SS, Mojiminiyi OA, Shihab-Eldeen A, Al Rammah T, Abdella N. 2011. Putative roles of circulating resistin in patients with asthma, COPD and cigarette smokers. Dis Markers 31(1), 1-7.

Arshi M, Cardinal J, Hill RJ, Davies PS, Wainwright C. 2010. Asthma and insulin resistance in children. Respirology 15(5), 779-84.

Büyüköztürk S, Gelincik AA, Genç S, Koçak H, Oneriyidogan Y, Erden S. 2004. Acute phase reactants in allergic airway disease. Tohoku J Exp Med 204(3), 209- 13.

de Salles BF, Simão R, Fleck SJ, Dias I, Kraemer-Aguiar LG, Bouskela E. 2010. Effects of resistance training on cytokines. Int J Sports Med 31(7), 441-50.

Ebrahim R, Hassan E, Hossein A, Vajihe C, Armin R. 2012. Evaluation of High-Sensitivity C -reactive protein in Acute Asthma. Tanaffos 11(1), 32-37.

Eizadi M, Ahmadi P, Nasiri FM, Torabi M. 2011. Exercise-induced weigh loss in the absence of a control diet does not affect serum resistin or insulin resistance in obese males. International Journal of Biosciences 1(2), 58-66.

Elmarakby AA, Sullivan JC. 2010. Relationship between Oxidative Stress and Inflammatory Cytokines in Diabetic Nephropathy. Cardiovasc Ther [Epub ahead of print].

Enright PL, Ward BJ, Tracy RP, Lasser EC. 1996. Asthma and its association with cardiovascular disease in the elderly. The Cardiovascular Health Study Research Group. J Asthma 33(1), 45- 53.

Filková M, Haluzík M, Gay S, Senolt L. 2009. The role of resistin as a regulator of inflammation: Implications for various human pathologies. Clin Immunol 133(2), 157-70.

Huang H, Iida KT, Sone H, Ajisaka R. 2007. The regulation of adiponectin receptors expression by acute exercise in mice. Exp Clin Endocrinol Diabetes 115(7), 417-22.

Jousilahti P, Salomaa V, Hakala K, Rasi V, Vahtera E, Palosuo T. 2002. The association of sensitive systemic inflammation markers with bronchial asthma. Ann Allergy Asthma Immunol 89(4), 381- 5.

Kelly AS, Steinberger J, Olson TP, Dengel DR. 2007. In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. Metabolism 56(7), 1005-9.

Kershaw E, Flier J. 2004. Adipose tissue as an endocrine organ. J. Clin. Endocrinol. Metab 89(6), 2548–2556.

Kim KW, Shin YH, Lee KE, Kim ES, Sohn MH, Kim KE. 2008. Relationship between adipokines and manifestations of childhood asthma. Pediatr Allergy Immunol [Epub ahead of print].

Larochelle J, Freiler J, Dice J, Hagan L. 2007. Plasma resistin levels in asthmatics as a marker of disease state. J Asthma. 44(7), 509-13.

Leivo-Korpela S, Lehtimäki L, Vuolteenaho K, Nieminen R, Kankaanranta H, Saarelainen S, Moilanen E. 2011. Adipokine resistin predicts anti-inflammatory effect of glucocorticoids in asthma. J Inflamm (Lond) 26, 8-12.

Mullis R, Campbell IT, Wearden AJ, Morriss RK, Pearson DJ. 1999. Prediction of peak oxygen uptake in chronic fatigue syndrome. British Journal of Sports Medicine 33(5), 352-6.

Steppan CM, Bailey ST, Bhat S. 2001. The hormone resistin links obesity to diabetes. Nature 409(6818), 307–312.

Tang Z, Yuan L, Gu C, Liu Y, Zhu L. 2005. Effect of exercise on the expression of adiponectin mRNA and GLUT4 mRNA in type 2 diabetic rats. J Huazhong Univ Sci Technolog Med Sci 25(2),191-3.

Tomaru T, Steger DJ, Lefterova MI, Schupp M, Lazar MA. 2009. Adipocyte-specific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor γ and CCAAT/enhancerbinding proteins,” The Journal of Biological Chemistry 284(10), 6116–6125.

Valsamakis G, McTernan PG, Chetty R, Al Daghri N, Field A, Hanif W, Barnett AH, Kumar S. 2004. Modest weight loss and reduction in waist circumference after medical treatment are associated with favorable changes in serum adipocytokines. Metabolism 53(4), 430-4.