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Review on genes involved in hereditary hypotrichosis

Zarmina Wali, Hasina Wali, Fazal-Ur-Rehman, Muhammad Ayub

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Int. J. Biosci.14(4), 123-134, April 2019

DOI: http://dx.doi.org/10.12692/ijb/14.4.123-134


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In human, hair loss disorders are the heterogeneous group of genetic disorders. The characteristics of the genetic hair disorders are thin to complete loss of hair, but rarely on scalp has firmly twisted curled woolly hair been reported. Pattern of the hair loss is also in autosomal recessive or autosomal dominant form. The genes which are responsible for autosomal recessive heredity hypotrichosis are LIPH gene mapped on chromosome number 3q27.2 and Lysophosphatidic acid receptor 6, also known as LPAR6 gene which is located on chromosome number 13q14.2, Desmoglein-4 (DSG4) gene on chromosome number 18q12.1, Desmocollin-3 (DSC3) gene on chromosome number 18q12.1 and Hairless (HR) gene on chromosome number 8p21.3. There are also some autosomal dominant genes which are responsible for heredity hypotrichosis. In this review, several genes and different mutations of the hair disorders are discussed.


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Review on genes involved in hereditary hypotrichosis

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