Role of oxidative stress in associated complications in type 2 diabetes mellitus patients, District Faisalabad, Pakistan

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Research Paper 01/01/2020
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Role of oxidative stress in associated complications in type 2 diabetes mellitus patients, District Faisalabad, Pakistan

Muzammal Sattar, Haseeb Anwar, Muhammad Naeem Faisal, Imran Mukhtar, Ghulam Hussain, Humaira Muzaffar, Muhammad Umar Sohail
Int. J. Biosci.16( 1), 178-183, January 2020.
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The present study was designed to evaluate the serum total antioxidant capacity and total oxidative stress in type 2 diabetic (T2D) patients without associated complications and T2D patients with associated complications. Fifty T2D patients (with or without secondary complications) and 25 healthy volunteers were selected from district head quarter hospital, Faisalabad, Pakistan. Participants were divided in to three groups; healthy control (HC), diabetic (Diab), and diabetic with secondary complications (DSC). Blood samples were collected to harvest serum. Total antioxidant capacity (TAC) and serum total oxidative stress (TOS) in the serum samples were evaluated by colorimetric method. Results were analyzed through one way ANOVA by using SPSS software. Diab and DSC groups had significantly (p=0 .05) higher blood glucose, and total oxidative stress as compared to HC group. But the total anti-oxidant capacity was significantly (p=0.05 ) lower in Diab and DSC groups as compared to HC group .Oxidative stress was increased in T2D patients with secondary complications and diabetic patients without associated complications.


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