Role of oxidative stress in associated complications in type 2 diabetes mellitus patients, District Faisalabad, Pakistan
Paper Details
Role of oxidative stress in associated complications in type 2 diabetes mellitus patients, District Faisalabad, Pakistan
Abstract
The present study was designed to evaluate the serum total antioxidant capacity and total oxidative stress in type 2 diabetic (T2D) patients without associated complications and T2D patients with associated complications. Fifty T2D patients (with or without secondary complications) and 25 healthy volunteers were selected from district head quarter hospital, Faisalabad, Pakistan. Participants were divided in to three groups; healthy control (HC), diabetic (Diab), and diabetic with secondary complications (DSC). Blood samples were collected to harvest serum. Total antioxidant capacity (TAC) and serum total oxidative stress (TOS) in the serum samples were evaluated by colorimetric method. Results were analyzed through one way ANOVA by using SPSS software. Diab and DSC groups had significantly (p=0 .05) higher blood glucose, and total oxidative stress as compared to HC group. But the total anti-oxidant capacity was significantly (p=0.05 ) lower in Diab and DSC groups as compared to HC group .Oxidative stress was increased in T2D patients with secondary complications and diabetic patients without associated complications.
Janghorbani M, Van dam RM, Willett WC, Hu FB. 2007. Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture. Americian Journal of Epidemiology 166, 495-505. PMID: 17575306 https://doi.org/ 10.1093/aje/kwm106.
Dominguez LJ, Muratore M, Quarta E, Zagone G, Barbagallo M. 2004. Osteoporosis and diabetes. Reumatismo 56, 235-241. PMID: 15643475 http://dx.doi.org/10.1371/journal.pone.0136390
Duarte VrMG, Ramos AMO, Rezende LA, Macedo UBO, Brandao-Neto J, Almeida MG, 2005. Osteopenia:a bone disorder associated with diabetes mellitus. Journal of Bone and Mineral Metabolism 23, 58-68. PMID: 15616896. http://dx.doi.org/10.1007/s00774-004-0542-y.
Seeleang K. 2011. “Genetic disparities in the development of type 2 diabetes among African Americans,” Journal of the American Academy of Nurse Practitioners 23(9), p 473-478, http://dx.doi.org/10.5402/2012/408079.
Reaven GM. 2000. Insulin resistance and its consequences: type 2 diabetes mellitus and coronary heart disease. Diabetes mellitus: A fundamental and clinical text, 604-615.
Grodsky GM. 2000. Kinetics of insulin secretion: underlying metabolic events in diabetes mellitus. In Diabetes Mellitu: A Fundamental and Clinical Text. Le Roith D, Taylor SI, Olefsky JM. Eds.Phiadelphia, http://dx.doi.org/10.2337/diabetes.52.1.1.
Maharjan BR, Jha JC, Adhikari D, Vishwanath P, Baxi J, Alurkar VM, Singh PP. 2008. A study of oxidative stress, antioxidant status and lipid profile in diabetic patient in the western region of Nepal. Kathmandu University medical journal (KUMJ), 6(1), 16-22.
Smriti K, Pai KM, Ravindranath V, Pentapati KC. 2016. Role of salivary malondialdehyde in assessment of oxidative stress among diabetics. Journal of oral biology and craniofacial research 6(1), 42-5. http://dx.doi.org/10.1016/j.jobcr.2015.12.004.
Tangvarasittichai S. 2015. Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus. World journal of diabetes 6(3), 456. http://dx.doi.org/10.4239/wjd.v6.i3.456.
Verma S, Sagar N, Vats P, Shukla K, Abbas M, Banerjee M. 2018. Antioxidant enzyme levels as markers for type 2 diabetes mellitus. International Journal of Bioassays 2(4), 685 -90. https://www.researchgat.net/publication/261510559.
Tangvarasittichai S. 2017. Serum levels of malondialdehyde in type 2 diabetes mellitus Thai subjects. Siriraj Medical Journal 61(1), 20-3. https://pdfs.semanticscholar.org/6051/b31666bea.
Bosch JA. 2014. The use of saliva markers in psychobiology: mechanisms and methods. Saliva: Secretion and Functions 24, Karger Publishers; p 99-108. http://dx.doi.org/10.1159/000358864.
Erel O. 2004. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clinical Biochemistry 37(4), 277-85. http://dx.doi.org/10.1016/j.clinbiochem.2003.11.015.
Erel O. 2005. A new automated colorimetric method for measuring total oxidant status; Clinical Biochemistry 38(12), 1103 -11. http://dx.doi.org/10.1016/j.clinbiochem.2005.08.008.
Moussa SA. 2008. Oxidative stress in Diabetes Mellitus, Romanian Journal of Biophysics 18(3), p 225-236. http://dx.doi.org/10.1.1.326.6470&rep=rep1&type=pdf.
Evans JL, Goldfine ID, Maddux BA, Grodsky GM. 2003. Are oxidative stress-activated signaling pathways mediators of insulin resistance and b-cell dysfunction? Diabetes 52, 1-8. http://dx.doi.org/10.2337/diabetes.52.1.1.
Farasat T, Cheema AM, Khan MN. 2009. Correlation Among BMI, Fasting Plasma Glucose and HbA 1c Levels in Subjects with Glycemic Anomalies Visiting Diabetic Clinics of Lahore Pakistan Journal of Zoology 41(3), p 173-178. http://dx.doi.org/0030-9923/2009/0003-0173
Fawwad A, Qasim R, Hydrie ZI, Basit A, Miyan Z, Gul A. 2006. Correlation of fasting insulin resistance indices with clinical parameters of metabolic syndrome in type 2 diabetic subjects. Pakistan Journal of medical. Sciences 2. http://dx.doi.org/433.53e61ff30cf2fb7487185a5c.
Varadharaj S, Kelly OJ, Khayat RN, Kumar PS, Ahmed N, Zweier JL. 2017. Role of Dietary Antioxidants in the Preservation of Vascular Function and the Modulation of Health and Disease. Frontiers in cardiovascular medicine 4. https://doi.org/10.3389/fcvm.2017.00064.
Zargari M, Arab H, Ghafouri Z. 2018. Evaluation of the Salivary Total Antioxidant Capacity and Lipid Peroxidation Status in Type 2 Diabetes Mellitus Patients: Iranian Journal of Diabetes and Obesity, Volume 10, Number 2. https://www.researchgate.net/publication/328275159.
Savu O, Tirgoviste CI, Atanasiu V, Gaman L, Papacocea R, Stoian I. 2012. Increase in Total Antioxidant Capacity of Plasma Despite High Levels of Oxidative Stress in Uncomplicated Type 2 Diabetes Mellitus; the Journal of International Medical Research 40, 709 716. http://dx.doi.org/10.1177/14733230011240
Muzammal Sattar, Haseeb Anwar, Muhammad Naeem Faisal, Imran Mukhtar, Ghulam Hussain, Humaira Muzaffar, Muhammad Umar Sohail (2020), Role of oxidative stress in associated complications in type 2 diabetes mellitus patients, District Faisalabad, Pakistan; IJB, V16, N1, January, P178-183
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