Role of resveratrol in cardiovascular and associated diseases

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Research Paper 01/02/2021
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Role of resveratrol in cardiovascular and associated diseases

Shehnai Basharat, Arooj Saeed, Wajeeha Bashir Baig, Tara Khursheed, Maria Amjad, Hafsa Tahir, Tabussam Tufail
Int. J. Biosci. 18(2), 130-136, February 2021.
Copyright Statement: Copyright 2021; The Author(s).
License: CC BY-NC 4.0

Abstract

Resveratrol is a potent bioactive compound found in fruits and taken as dietary supplements. Due to possessing multiple beneficial properties; anti-oxidant, anti-atherosclerosis, cardioprotective, anti-cholesterolemia and glucose regulation. It combats with globally high mortality and morbidity rate diseases. Resveratrol deals with cardiovascular disease and other associated diseases after the result of ROS accumulation. It seems successful in nutraceutical and pharmaceutical to prevent and treat cancer proliferation, diabetes, diabetic-cardiomyocyte, neuropathy, nephropathy and obesity.

Ko JH, Sethi G, Um JY, Shanmugam MK, Arfuso F, Kumar AP, Bishayee A, Ahn KS. 2017 The role of resveratrol in cancer therapy. International journal of molecular sciences 18(12), 2589.

Elshaer M, Chen Y, Wang XJ, Tang X. 2018 Resveratrol: An overview of its anti-cancer mechanisms. Life sciences 15(207), 340-9.

Zordoky BN, Robertson IM, Dyck JR. 2015. Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1(6), 1155-77.

Abdelgawad IY, Grant MK, Zordoky BN. 2019. Leveraging the cardio-protective and anticancer properties of resveratrol in cardio-oncology. Nutrients 11(3), 627.

Ahmet I, Tae HJ, Lakatta EG, Talan M. 2017. Long-term low dose dietary resveratrol supplement reduces cardiovascular structural and functional deterioration in chronic heart failure in rats. Canadian journal of physiology and pharmacology. 95(3), 268-74.

Mohammed S, Harikumar KB. 2018. Role of Resveratrol in Chemosensitization of Cancer. In Role of Nutraceuticals in Cancer Chemosensitization (p 61-76). Academic Press.

Siddiqui IA, Sanna V, Ahmad N, Sechi M, Mukhtar H. 2015.  Resveratrol nanoformulation for cancer prevention and therapy. Ann. NY Acad. Sci. 1(1), 20-31.

Tabrez S, Jabir NR, Adhami VM, Khan MI, Moulay M, Kamal MA, Mukhtar H. 2020. Nanoencapsulated dietary polyphenols for cancer prevention and treatment: successes and challenges. Nanomedicine. (0).

Guthrie AR, Chow HH, Martinez JA. 2017.  Effects of resveratrol on drug‐and carcinogen‐metabolizing enzymes, implications for cancer prevention. Pharmacology research & perspectives. 5(1), e00294.

Yan F, Sun X, Xu C. 2018. Protective effects of resveratrol improve cardiovascular function in rats with diabetes. Experimental and therapeutic medicine 15(2), 1728-34.

Xia N, Daiber A, Förstermann U, Li H. 2017. Antioxidant effects of resveratrol in the cardiovascular system. British journal of pharmacology 174(12), 1633-46.

Meng X, Zhou J, Zhao CN, Gan RY, Li HB. 2020. Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review. Foods. 9(3), 340.

Fang WJ, Wang CJ, He Y, Zhou YL, Peng XD, Liu SK. 2018.  Resveratrol alleviates diabetic cardiomyopathy in rats by improving mitochondrial function through PGC-1α deacetylation. Acta Pharmacologica Sinica 39(1), 59-73.

Hosseini H, Koushki M, Khodabandehloo H, Fathi M, Panahi G, Teimouri M, Majidi Z, Meshkani R. 2020. The effect of resveratrol supplementation on C-reactive protein (CRP) in type 2 diabetic patients: Results from a systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine. 102251.

Wong RH, Nealon RS, Scholey A, Howe PR. 2016. Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus. Nutrition, Metabolism and Cardiovascular Diseases 26(5), 393-9.

Mankowski RT, You L, Buford TW, Leeuwenburgh C, Manini TM, Schneider S, Qiu P, Anton SD. 2020. Higher dose of resveratrol elevated cardiovascular disease risk biomarker levels in overweight older adults–A pilot study. Experimental Gerontology 131, 110821.

Portillo MP, Fernandez-Quintela A. 2019.  Benefits of Resveratrol Supplementation. MDPI-Multidisciplinary Digital Publishing Institute.

Siddiqui IA, Sanna V, Ahmad N, Sechi M, Mukhtar H. 2015. Resveratrol Nano formulation for cancer prevention and therapy. Annals of the New York Academy of Sciences 1348(1), 20-31.

Kotecha R, Takami A, Espinoza JL. 2016. Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence. Oncotarget 7(32), 52517.

Mohammadshahi M, Haidari F, Soufi FG. 2014. Chronic resveratrol administration improves diabetic cardiomyopathy in part by reducing oxidative stress. Cardiology journal 21(1), 39-46.

Tufail T, Saeed F, Imran M, Arshad MU, Anjum FM, Afzaal M, Bader Ul Ain H, Shahbaz M, Gondal TA, Hussain S. 2018. Biochemical characterization of wheat straw cell wall with special reference to bioactive profile. International journal of food properties 21(1), p 1303-1310.

Tufail T, Saeed F, Arshad MU, Afzaal M, Rasheed R, Bader Ul Ain H, Imran M, Abrar M, Farooq MA, Shahid MZ. 2020. Exploring the effect of cereal bran cell wall on rheological properties of wheat flour. Journal of Food Processing and Preservation 44(3), p e14345.

Truong J. The Cytotoxic Effects of Methylmercury on Cardiomyocytes: A Possible Implication for Heart Diseases? (Doctoral dissertation, University of Ottawa).

Prasad K. 2012. Resveratrol, wine, and  atherosclerosis. International Journal of Angiology. 21(01), 007-18.

Aguirre L, Fernández-Quintela A, Arias N, Portillo MP. 2014. Resveratrol: anti-obesity mechanisms of action. Molecules 19(11), 18632-55.

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