Screening of antibacterial, antifungal and cytotoxic activities of Polygonum hydropiper L. stem extracts

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Research Paper 01/12/2011
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Screening of antibacterial, antifungal and cytotoxic activities of Polygonum hydropiper L. stem extracts

Mohammad Faruk Hasan, Mohammad Motiur Rahman
Int. J. Biosci.1( 6), 47-53, December 2011.
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Abstract

The aim of the study was to investigate the antibacterial, antifungal and cytotoxic activities of ethanol extract of Polygonum hydropiper stem. Disc diffusion method measuring minimum inhibitory concentration (MIC) was used todemonstrate antibacterial and antifungal activities. Stem extract showed significant antibacterial activities against three gram-positive (Bacillus subtilis, Bacillus megaterium and Staphylococcus aureus) and four gram-negative (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and Shigella sonnei) bacteria resulting 16 to 64 mg/ml MIC values against these bacteria. Further, the antifungal activities of stem extract were not highly remarked but still to be considered as inhibitory to tested fungi. LC50 of the extract against brine shrimp nauplii was 35.46mg/ml and indicates the cytotoxic potentiality of Polygonum hydropiper stem. Results obtained in this study suggest that Polygonum hydropiper stem can also be used as a source of antimicrobial and cytotoxic substances for possible forplant protections.

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