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Research Paper | April 1, 2014

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Search for polymorphism in growth and differentiation factor 9 (GDF9) gene in prolific beetal and tali goats (Capra hircus)

Morteza Hadizadeh, Mohammad Reza Mohammadbadi, Ali Niazi, Ali Esmailizadeh, Yasser Mahdizadeh Gazooei

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J. Bio. Env. Sci.4(4), 186-191, April 2014

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Abstract

Growth and differentiation factor 9 gene is one of the main genes controlling prolificacy in sheep and goat. Mutations in this gene affect litter size in a dosage sensitive manner so that heterozygous animals have litter size records higher than wild types while the mutant homozygous animals are sterile. In this study, we analyzed exon 2 of the growth and differentiation factor 9 as a candidate gene for high prolificacy in Tali and Beetal goats, the common prolific breeds of goats reared in southern and southeast Iran. The results showed a cytosine to thymine nucleotide change at the position of 881 in Beetal goats causing the replacement of alanine with valine at the position of 273 in the unprocessed protein. The results provided further evidence that this amino acid change can affect functions of the protein through changing the conformation of its third structure in Beetal goats.

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Search for polymorphism in growth and differentiation factor 9 (GDF9) gene in prolific beetal and tali goats (Capra hircus)

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