Serological evidence and associated risk factors of toxoplasmosis among pregnant women in District Mardan, Khyber Pakhtunkhwa, Pakistan

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Research Paper 01/08/2018
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Serological evidence and associated risk factors of toxoplasmosis among pregnant women in District Mardan, Khyber Pakhtunkhwa, Pakistan

Mudassir Shah, Muhammad Zahid, Sobia Attaullah
Int. J. Biosci.13( 2), 179-186, August 2018.
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Toxoplasmosis is one of the widely distributed zoonotic disease which is caused by an intracellular protozoan parasite Toxoplasma gondii. The objective of this study was to determine the seroprevalence and risk factors associated with infection in pregnant women of District Mardan, Khyber Pakhtunkhwa, Pakistan. Blood sample of 5mL was taken and the serum was tested for T. gondii IgG and IgM antibodies using Indirect Enzyme-Linked Immunosorbent Assay (ELISA) technique. Further information was collected by using preplanned questionnaire. A total of 1200 samples were tested for toxoplasmosis, out of which 39.5% were positive. Among seropositive pregnant women the seropositivity for IgG, IgM and both IgG and IgM antibodies was 43.03%, 40.5% and 16.45% respectively. The seropositivity was highest (58.18%) in age group 36-45 whereas lowest (33.92%) in age group 26-35 which was statistically significant. The findings of the present study suggest that T. gondii infection is widely spread in the study area which may constitute a significant risk for congenital defects, stillbirths and abortions during pregnancy in women. Screening for the infection among pregnant women can be done twice at least during pregnancy to protect both mother and child from toxoplasmosis. There should be proper awareness in the educational institutes as well as community awareness programs about the risk factors of toxoplasmosis.


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