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Research Paper | September 1, 2012

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Serum adiponectin and insulin sensitivity affect by aerobic exercise program in patients with type 2 diabetes mellitus

Ahmadi Pezhman, Torabi Mohsen, Aran Ardabili Akbar, Aghazadeh Javad

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Int. J. Biosci.2(9), 94-101, September 2012


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Obesity and type 2 diabetic are strongly related to cardiovascular disease. The objective of this study was to investigation whether a long time aerobic training program affects adiponectin and insulin sensitivity in patients with type 2 diabetic. A total of 30 obese males with type 2 diabetic were randomly assigned to either a 3-month aerobic exercise training program (3 sessions/wk) designated as experimental group, or to the control group. Also, 15 non-obese adult male participated as healthy group in the study to compare the baseline levels of biochemical indexes with that of diabetic patients. Fasting adiponectin, glucose, insulin sensitivity (HOMA-IS) were measured at baseline and at the end of the study in all diabetic patients. Statistical analyses was performed with the SPSS software using a T- test method to comparing of baseline between diabetic and healthy subjects, and determine the effect aerobic exercise on all variables in experimental group of diabetic. At baseline, serum adiponectin and insulin sensitivity in diabetic patients was significantly lower and fasting glucose was significantly higher than healthy subjects (P<0.05). Serum adiponectin and insulin sensitivity following aerobic exercise significantly increased in the experimental group (P <.05). In addition, exercise training reduced fasting glucose, body weight, body fat percentage and body mass index in this group (P<0.05). All variables remained without change in control group (p>0.05). Our study shows that aerobic exercise-induced weight loss increases adiponectin as anti-diabetic cytokine and improves insulin action in patients with type 2 diabeti.


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Serum adiponectin and insulin sensitivity affect by aerobic exercise program in patients with type 2 diabetes mellitus

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