Serum adiponectin and insulin sensitivity affect by aerobic exercise program in patients with type 2 diabetes mellitus

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Research Paper 01/09/2012
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Serum adiponectin and insulin sensitivity affect by aerobic exercise program in patients with type 2 diabetes mellitus

Ahmadi Pezhman, Torabi Mohsen, Aran Ardabili Akbar, Aghazadeh Javad
Int. J. Biosci.2( 9), 94-101, September 2012.
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Abstract

Obesity and type 2 diabetic are strongly related to cardiovascular disease. The objective of this study was to investigation whether a long time aerobic training program affects adiponectin and insulin sensitivity in patients with type 2 diabetic. A total of 30 obese males with type 2 diabetic were randomly assigned to either a 3-month aerobic exercise training program (3 sessions/wk) designated as experimental group, or to the control group. Also, 15 non-obese adult male participated as healthy group in the study to compare the baseline levels of biochemical indexes with that of diabetic patients. Fasting adiponectin, glucose, insulin sensitivity (HOMA-IS) were measured at baseline and at the end of the study in all diabetic patients. Statistical analyses was performed with the SPSS software using a T- test method to comparing of baseline between diabetic and healthy subjects, and determine the effect aerobic exercise on all variables in experimental group of diabetic. At baseline, serum adiponectin and insulin sensitivity in diabetic patients was significantly lower and fasting glucose was significantly higher than healthy subjects (P<0.05). Serum adiponectin and insulin sensitivity following aerobic exercise significantly increased in the experimental group (P <.05). In addition, exercise training reduced fasting glucose, body weight, body fat percentage and body mass index in this group (P<0.05). All variables remained without change in control group (p>0.05). Our study shows that aerobic exercise-induced weight loss increases adiponectin as anti-diabetic cytokine and improves insulin action in patients with type 2 diabeti.

VIEWS 6

Ahima RS. 2006. Metabolic actions of adipocyte hormones: focus on adiponectin . Obesity 14(1), 9– 15.

Ajuwon KM, Spurlock ME. 2005. Adiponectin inhibits LPS-induced NF-kappaB activation and IL-6 production and increases PPARgamma2 expression in adipocytes. Am J Physiol Regul Integr Comp Physiol 288(5), 1220–1225.

Berg AH, Scherer PE. 2005. Adipose tissue , inflammation, and cardiovascular disease . Circ Res 96(9), 939–949.

Bluher M, Bullen JW Jr, Lee JH. 2006. Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training. J Clin Endocrinol Metab 91(6), 2310–2316.

Braith RW, Stewart KJ. 2006. Resistance exercise training: its role in the prevention of cardiovascular disease. Circulation 113(22), 2642– 2650.

Brooks N, Layne JE, Gordon PL, Roubenoff R, Nelson ME ,Castaneda-Sceppa C. 2007. Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes. Int J Med Sci 4(1), 19–27.

Bruun JM, Lihn AS, Verdich C, Pedersen SB, Toubro S, Astrup A, Richelsen B. 2003. Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab 285(3), 527– 33.

Fasshauer M, Kralisch S, Klier M. 2003. Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3- L1 adipocytes. Biochem Biophys Res Commun 301(4), 1045-1050.

Ford ES, Mokdad AH, Giles WH, Mensah GA. 2003.  Serum  total  cholesterol  concentrations  and awareness, treatment, and control of hypercholesterolemia among US adults. Findings from the National Health and Nutrition Examination Survey, 1999 to 2000. Circulation 107, 2185–9.

Hulver MW, Zheng D, Tanner CJ. 2002. Adiponectin is not altered with exercise training despite enhanced insulin action. Am J Physiol Endocrinol Metab 283(4), 861–865.

Ibáñez J, Izquierdo M, Martínez-Labari C, Ortega F, Grijalba A, Forga L. 2010. Resistance Training Improves cardiovascular Risk Factors in Obese Women despite a Signifcative Decrease in Serum adiponectin Levels. Obesity (Silver Spring) 18(3), 535-41.

Imbeault P. 2007. Environmental influences on adiponectin levels in humans. Appl Physiol Nutr Metab 32(3), 505-11.

Izquierdo M, Häkkinen K, Ibañez J. 2001. Effects of strength training on muscle power and serum hormones in middle-aged and older men. J Appl Physiol 90(4), 1497–1507.

Julius U. 2003. Influence of plasma free fatty acids on lipoprotein synthesis and diabetic dyslipidemia. Exp Clin Endocrinol Diabetes 111(5), 246-50.

Katz A, Nambi SS, Mather K, Baron AD,Follmann DA, Sullivan G, Quon MJ. 2000. Quantitative insulin sensitivity check index: asimple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85(7), 2402–10.

KriketosAD,GanSK,PoyntenAM,FurlerSM,Ch isholmDJ, Campbell LV. 2004. Exercise increases adiponectin levels and insulin sensitivity in humans. Diabetes Care 27(2), 629–630.

Lara-Castro C, Luo N, Wallace P, Klein RL, Garvey WT. 2006. Adiponectin multimeric complexes and the metabolic syndrome trait cluster. Diabetes 55(1), 249-259.

Madsen EL, Rissanen A, Bruun JM, Skogstrand K, Tonstad S, Hougaard DM, Richelsen B. 2008. Weight loss larger than 10% is needed for general improvement of levels of circulating adiponectin and markers of inflammation in obese subjects: a 3-year weight loss study. Eur J Endocrinol 158(2), 179–87.

Nakai N, Miyazaki Y, Sato Y, Oshida Y, Nagasaki M, Tanaka M. 2002. Exercise training increases the activity of pyruvate dehydrogenase complex in skeletal muscle of diabetic rats. Endocr J 49(5), 547-54.

Ng TW, Watts G, Barrett PH, Rye KA, Chan DC. 2007. Effect of weight loss on LDL and HDL kinetics in the metabolic syndrome: associations with changes in plasma retinol-binding protein-4 and adiponectin levels. Diabetes Care 30(11), 2945– 50.

Oberbach A, Tonjes A, Kloting N. 2006. Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. Eur J Endocrinol 154(4), 577–585.

Ouchi N, Kihara S, Funahashi T, Nakamura T, Nishida M, Kumada M. 2003. Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation 107(5), 671–4.

Pischon T, Rimm EB. 2006. Adiponectin: a promising marker for cardiovascular disease. Clin Chem 52(5), 797–799.

Puglisi MJ, Fernandez ML. 2008. Modulation of C-reactive protein, tumor necrosis factor-alpha, and adiponectin by diet, exercise, and weight loss. J Nutr 138(12), 2293-6.

Sigal RJ, Kenny GP, Wasserman DH, Castaneda-Sceppa C, White RD. 2006. Physical activity/exercise and type 2 diabetes: a consensus statement from the American diabetes association. Diabetes Care 29(6), 1433–1438.

Simpson KA, SinghMA. 2008. Effects of exercise on adiponectin: a systematic review. Obesity (Silver Spring) 16(2), 241–56.

Tang Z, Yuan L, Gu C, Liu Y, Zhu L. 2005. Effect of exercise on the expression of adiponectin mRNA and GLUT4 mRNA in type 2 diabetic rats. J Huazhong Univ Sci Technol Med Sci 25(2), 191– 193.

Vivian V, Michael CR, Gary S. 2007. Circulating adiponectin and adiponectin receptor expression in skeletal muscle: effects of exercise. Diabetes Metab Res Rev 23(8), 600–611.

Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S. 2002. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8(11), 1288–95.

Zeng Q, Isobe K, Fu L. 2007. Effects of exercise on adiponectin and adiponectin receptor levels in rats. Life Sci 8, 454-459.