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Research Paper | February 1, 2011

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Serum adiponectin is not related with insulin resistance and fasting glucose in asthma patient

Eizadi Mojtaba, Khorshidi Davood, Dooaly Hussein, Samarikhalaj Hamidreza

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Int. J. Biosci.1(1), 82-91, February 2011

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Abstract

Research evidence shows that obesity is associated with asthma and its severity. The specific mechanisms responsible for these observations are not obvious. The study objective was to determine whether the serum adiponectin concentration was associated with asthma and insulin resistance in asthma patients. Methods: For this purpose, we measured fasting serum adiponectin, insulin and glucose in 44 mild to moderate asthma with a mean body mass index (BMI) of 31.3 +/- 4.14 kg/m2. A spirometry test was performed in order to asthma diagnosis and its severity. Insulin resistance was calculated by fasting glucose and insulin. Pearson correlations were used to establish the relationship between adiponectin concentration with insulin resistance and spirometry indexes. Results: Serum adiponectin concentration was positively related to FEV1/FVC as a marker of asthma diagnosis. Additionally, although fasting serum adiponectin tended to be negatively correlated with insulin resistance and glucose, this did not reach statistical significance (P<0.086). Based on this data, it was concluded that although adiponectin is not related with insulin resistance in asthma patients, but its measuring may be a predictor of asthma severity in patients.

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Serum adiponectin is not related with insulin resistance and fasting glucose in asthma patient

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