Serum adiponectin is not related with insulin resistance and fasting glucose in asthma patient

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Research Paper 01/02/2011
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Serum adiponectin is not related with insulin resistance and fasting glucose in asthma patient

Eizadi Mojtaba, Khorshidi Davood, Dooaly Hussein, Samarikhalaj Hamidreza
Int. J. Biosci.1( 1), 82-91, February 2011.
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Research evidence shows that obesity is associated with asthma and its severity. The specific mechanisms responsible for these observations are not obvious. The study objective was to determine whether the serum adiponectin concentration was associated with asthma and insulin resistance in asthma patients. Methods: For this purpose, we measured fasting serum adiponectin, insulin and glucose in 44 mild to moderate asthma with a mean body mass index (BMI) of 31.3 +/- 4.14 kg/m2. A spirometry test was performed in order to asthma diagnosis and its severity. Insulin resistance was calculated by fasting glucose and insulin. Pearson correlations were used to establish the relationship between adiponectin concentration with insulin resistance and spirometry indexes. Results: Serum adiponectin concentration was positively related to FEV1/FVC as a marker of asthma diagnosis. Additionally, although fasting serum adiponectin tended to be negatively correlated with insulin resistance and glucose, this did not reach statistical significance (P<0.086). Based on this data, it was concluded that although adiponectin is not related with insulin resistance in asthma patients, but its measuring may be a predictor of asthma severity in patients.


Al-Shawwa BA, Al-Huniti NH, DeMattia L, Gershan W.2007. Asthma and insulin resistance in morbidly obese children and adolescents. J Asthma 44(6), 469-73.

Benjamin D. Yoshihisa O, Patricio L, Meiqian W, Barry P, Sandall MJ. 2009. Adiponectin Deficiency Increases Allergic Airway Inflammation and Pulmonary Vascular Remodeling. Am J Respir Cell Mol Biol 41, 397–406.

Boulet LP. 2008. Influence of obesity on the prevalence and clinical features of asthma. Clin Invest Med 31(6), 386-90.

Castro-Rodríguez JA, Holberg CJ, Morgan WJ, Wright AL, Martinez FD. 2001. Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years. Am J Respir Crit Care Med 163, 1344-9.

Castro-Rodríguez JA. 2007. Relationship between obesity and asthma Arch Bronconeumol 43(3), 171-5.

Engeli S, Feldpausch M, Gorzelniak K, Hartwig F, Heintze U, Janke J. 2003. Association between adiponectin and mediators of inflammation in obese women. Diabetes 52, 942-7.

Genuth S, Alberti KG, Bennett P, Buse J, Defronzo R, Kahn R. 2003. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26, 3160-3167.3

Gurkan F, Atamer Y, Ece A, Kocyigit Y, Tuzun H, Mete N. 2004. Leptin and asthma in overweight children at 12 years of age. Pediatr Allergy Immunol 15(6), 523-30.

Hadaegh F, Harati H, Ghanbarian A, Azizi F. 2006. Association of total cholesterol versus other serum lipid parameters with the short-term prediction of cardiovascular outcomes: Tehran Lipid and Glucose Study. Eur J Cardiovasc Prev Rehabil 13, 571-577.

Hotta K, Funahashi T, Bodkin NL, Ortmeyer HK, Arita Y, Hansen BC. 2001. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50, 1126-33.

Klok MD, Jakobsdottir S, Drent ML. 2007. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes Rev 8(1), 21-34.

Marita AR, Sarkar JA, Rane S. 2005. Type 2 diabetes in non-obese Indian subjects is associated with reduced leptin levels: Study from Mumbai, Western India. Molecular and Cellular Biochemistry 275, 143–151.

Meilleur  KG,  Doumatey  A,  Huang  H,  Charles  B,  Chen  G,  Zhou  J.  2010. Circulating adiponectin is associated with obesity and serum lipids in West Africans. J Clin Endocrinol Metab 95(7), 3517-21.

Nayak BS, Ramsingh D, Gooding S, Legall G, Bissram S, Mohammed A. 2010. Plasma adiponectin levels are related to obesity, inflammation, blood lipids and insulin in type 2 diabetic and non-diabetic Trinidadians. Prim Care Diabetes [Epub ahead of print].

Nystad W, Meyer HE, Nafstad P, Tverdal A, Engeland A. 2004. Body mass index in relation to adult asthma among 135,000 Norwegian men and women. Am J Epidemiol 160(10), 969-76.

Ouchi N. 2003. Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension 42, 231–234.

Pischon T. 2004. Plasma adiponectin levels and risk of myocardial infarction in men. JAMA 291, 1730–1737. 

Shore SA, Terry RD, Flynt L. 2006. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 118, 389–95.

Sood A, Cui X, Qualls C, Beckett WS, Gross MD, Steffes MW. 2008. Association between Asthma and Serum Adiponectin Concentration in Women. Association between Asthma and Serum Adiponectin Concentration in Women. Thorax [Epub ahead of print].

Sowers JR. 2008. Endocrine functions of adipose tissue: focus on adiponectin. Clin Cornerstone 9(1), 32-8.

Stefanyk LE, Dyck DJ. 2010. The interaction between adipokines, diet and exercise on muscle insulin sensitivity. Curr Opin Clin Nutr Metab Care 13(3), 255-9.

Takashi K, Toshimasa Y, Naoto K, Kazuo H, Kohjiro U, Kazuyuki T. 2006. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J. Clin. Invest 116, 1784–1792.