Serum C-reactive protein and glycosylated hemoglobin in response to aerobic training in diabetic patients

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Research Paper 01/08/2012
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Serum C-reactive protein and glycosylated hemoglobin in response to aerobic training in diabetic patients

Ahmadi Pezhman, Torabi Mohsen, Aran Ardabili Akbar, Aghazadeh Javad
Int. J. Biosci.2( 8), 115-119, August 2012.
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Accumulating evidence indicates that obesity and overweight are associated with chronic low grade inflammation. The aim of our work was to study the effect aerobic exercise training on glycosylated hemoglobin and acute phase C-reactive protein (CRP) in diabetic patients. Thirty-eight sedentary, nonsmoking, type II diabetic (BMI: 30–35 kg/m2) men, aged 38–46 years, were recruited to participate to study and divided in to exercise (3 months, 3 sessions/weekly) and control (no training) group by randomly. Pre and post training CRP, glycosylated hemoglobin and anthropometrical parameters were measured in exercise and control groups and compared with each other. Aerobic exercise training resulted in significant decrease in body weight, body mass index and body fat percentage in exercise group (p<0.05). Glycosylated hemoglobin levels were significantly decreased in response to exercise training when compared with baseline levels (p=0.033). But, serum CRP did not change with aerobic exercise training. All variables in control group remained without changes. We conclude that there are no meaningful chronic effects of exercise on serum CRP, even in presence a improving in glycosylated hemoglobin in diabetic patients.


Bautmans I, Njemini R, Vasseur S. 2005. Biochemical changes in response to intensive resistance exercise training in the elderly. Gerontology 51, 253–265.

Boulé NG, Haddad E, Kenny GP, Wells GA, Sigal RJ. 2011. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA 286(10), 1218-27.

Campbell KL, Campbell PT, Urich CM, Wener M, Alfano CM, Foster-Schubert K, Rudolph RE, Potter JD. 2008. No reduction in C-reactive protein following a 12-month randomized controlled trial of exercise in men and women. Cancer Epidemiol Biomarkers Prev 17, 1714–8.

de Visser KE, Eichten A & Coussens LM. 2006. Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 6, 24–37.

Fischer CP, Plomgaard P, Hansen AK. 2004. Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle. Endocrinol Metabol 287, 1189–1194.

Glans F, Eriksson KF, Segerström A, Thorsson O, Wollmer P, Groop L. 2009. Evaluation of the effects of exercise on insulin sensitivity in Arabian and Swedish women with type 2 diabetes. Diabetes Res Clin Pract 85(1), 69-74.

Goldhaber-Fiebert JD, Goldhaber-Fiebert SN, Tristán ML, Nathan DM 2003. Randomized controlled community-based nutrition and exercise intervention improves glycemia and cardiovascular risk factors in type 2 diabetic patients in rural Costa Rica. Diabetes Care 26(1), 24-9.

Hammett CJK, Prapavessis H, Baldi JC. 2006. Effects of exercise training on 5 inflammatory markers associated with cardiovascular risk. Am Heart J 151, 367.

Kim SK, Jung I, Kim JH. 2008. Exercise reduces C-reactive protein and improves physical function in automotive workers with low back pain. J Occup Rehabil 18, 218–22.

Kohut ML, McCann DA, Russell DW. 2006. Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults. Brain Behav Immun 20, 201– 209.

Li CZ , Xue YM, Gao F, Wang M. 2004. Determination of serum hs-CRP in patients with type 2 diabetes mellitus . Di Yi Jhun Yi Da Xne Xne Bao 24( 7), 791-793.

Marcell  TJ,  McAuley  KA,  Traustadottir  T. 2005. Exercise training is not associated with improved levels of C-reactive protein or adiponectin. Metabolism 54, 533–541.

Ndumele CE, Pradhan AD, Ridker PM. 2006. Interrelationships between inflammation, C-reactive protein, and insulin resistance. J Cardiometab Syndr 1(3), 190-6.

Ouchi N, Kihara S, Funahashi T, Nakamura T, Nishida M, Kumada M, Okamoto Y, Ohashi K, Nagaretani H. 2003. Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation 107, 671–4.

Panagiotakos DB, Pitsavos C, Chrysohoou C, Skoumas E, Stefanadis C. 2008. Five-year incidence of cardiovascular disease and its predictors in Greece: the ATTICA study. Vasc Med 13, 113–21.

Pischon T, Hankinson SE, Hotamisligil GS. 2003. Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers. Obes Res 11, 1055–1064.

Pradhan AD, Cook NR, Buring JE, Manson JE, Ridker PM. 2003. C-reactive protein is independently associated with fasting insulin in nondiabetic women. Arterioscler Thromb Vasc Biol 23(4), 650-5.

Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. 2001. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286, 327–334.

Pradhan AD, Manson JE, Rifai. N, Burning JE, Ridker PM. 2001. C-reactive protein, interleukin 6 and risk development type 2 diabetes mellitus. JAMA 286, 327-334.

Ridker PM. 2001. High-sensitivity C-reactive protein: Potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation 103, 1813–1818.

Ridker PM. 2003. Clinical application of C-reactive protein for cardiovascular disease detection and prevention [review]. Circulation 107, 363–369.

Safiullah A, Abdulla J, Muralikrishnan G, Mohamed IB, Saira k. 2010. Association of hs-CRP with Diabetic and Non-diabetic individuals. Jordan Journal of Biological Sciences 3(1), 7-12.

Smith JK, Dykes R, Douglas JE. 1999. Long-term exercise and atherogenic activity of blood mononuclear cells in persons at risk of developing ischemic heart disease. JAMA 281, 1722–1727.

Stewart LK, Flynn MG, Campbell WW. 2005. Influence of exercise training and age on CD14 + cell-surface expression of toll-like receptor 2 and 4. Brain Behav Immun 19, 389–397.

Tokmakidis SP, Zois CE, Volaklis KA, Kotsa K, Touvra AM. 2004. The effects of a combined strength and aerobic exercise program on glucose control and insulin action in women with type 2 diabetes. Eur J Appl Physiol 92(4-5), 437-42.

Vancea DM, Vancea JN, Pires MI, Reis MA, Moura RB, Dib SA. 2009. Effect of frequency of physical exercise on glycemic control and body composition in type 2 diabetic patients. Arq Bras Cardiol 92(1), 23-30.

Wang Z, Hoy WE. 2007. C-reactive protein and the risk of developing type 2 diabetes in Aboriginal Australians. Diabetes Res Clin Pract 76(1), 37-43.