Welcome to International Network for Natural Sciences | INNSpub

Paper Details

Research Paper | January 1, 2016

| Download 4

Serum Copper and Zinc level as biomarker for dust exposed lung diseases among coal miners

Deepa Agarwal, Jai Krishna Pandey, Bably Prasad, Asim Kumar Pal

Key Words:

J. Bio. Env. Sci.8(1), 65-74, January 2016


JBES 2016 [Generate Certificate]


To elucidate the effect of dust exposure, smoking and alcoholic habit on the serum Copper and Zinc activity as prognosis tool for dust linked lung diseases among coal workers. In the present study, serum Copper and Zinc activity have been examined and correlated with PFT among coal mine workers to determine the extent of lung fibrosis. A cross-sectional study was conducted on two statistically similar groups consisting of 54 dust exposed miners and 50 unexposed control. PFT values using spirometry and serum Cu and Zn level by AAS were determined for all the test subjects. Serum Cu and Zn level increases significantly with duration of dust exposure among miners whereas their PFT values suggest deterioration in lung. Smokers had significantly higher levels of serum Cu (87.38±6.31µg/dl) and Zinc (80.07±5.59 µg/dl) as compared to non-smokers having values 81.50±5.01 µg/dl and 78.62±3.11 µg/dl respectively. Alcoholic habit further deteriorates the PFT values and increases serum Cu and Zn values. The study reveals that serum Cu and Zn concentrations were found to be at significantly higher levels in exposed workers which increases further with smoking and drinking habits. PFT investigations on these subjects suggest that serum Cu and Zn very well correlates with PFT and is a more sensitive indicator for health status of miner’s lung than PFT. This suggests strong possibility of serum Cu and Zn as biomarker for dust linked lung diseases like silicosis.


Copyright © 2016
By Authors and International Network for
Natural Sciences (INNSPUB)
This article is published under the terms of the Creative
Commons Attribution Liscense 4.0

Serum Copper and Zinc level as biomarker for dust exposed lung diseases among coal miners

Bai Y, Wang JJ, Wei SC, Hao DQ. 1993. Changes of trace element copper and zinc in sera of cases with silicosis. Chinese Journal of Industrial Hygiene and Occupational Diseases 11, 280-280.

Castranova V, Vallyathan V. 2000. Silicosis and coal workers’ pneumoconiosis. Environ Health Perspect 108, 675-684.

Fubini B, Hubbard A. 2003. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radicals in Biology & Medicine 34, 1507-1516.

Gulumian M, Borm PJ, Vallyathan V, Castranova V, Donaldson K, Nelson G, Murray J. 2006. Mechanistically identified suitable biomarkers of exposure, effect, and susceptibility for silicosis and coal-worker’s pneumoconiosis: a comprehensive review. Journal of Toxicology and Environmental Health, Part B: Critical Reviews 9, 357-95.

Hnizdo E, Vallyathan V. 2003. Chronic obstructive pulmonary disease due to occupational exposure to silica dust: a review of epidemiological and pathological evidence. Occupational and Environmental Medicine 60, 237-243.

Humerfelt S, Eide GE, Gulsvik A. 1998. Association of years of occupational quartz exposure with spirometric airflow limitation in Norwegian menaged 30-46 years. Thorax 53, 649-655.

Jia ZG. 1991. Analysis of serum levels of selenium, zinc, and copper in 132 patients with malignant tumors. Chung Hua Yu Fang I Hsueh Tsa Chich 25, 205-207.

Kolev K, Burkova T. 1982. Histochemical mechanisms in etiology of pulmonary fibrosis after short-term exposure to a mixture of dust and quartz from copper mine. Probl Khig 7, 88-97.

Konishi A, Iguchi H, Ochi J, Kinoshita R, Miura K, Uchino H. 1985. Increased lysyl oxidase activity in culture medium of non – parenchymal cells from fibrotic levers. Gastroenterology 89, 709-715.

Ma EL, Jiang ZM. 1993. Ion – exchange chromatography in simultaneous determination of serum, copper and zinc levels inneous determination of serum, copper and zinc levels in patients with cancer of digestive tract. Chinese Medical Journal 106, 118-121.

Malvy DJ, Burtschy B, Arnaud J, Sommelet D, Leverger G, Dostalova L, Drucker J, Amedee-Manesme O. 1993. Serum beta-carotene and antioxidant micronutrients in children with cancer, The ‘Cancer in children and antioxidant micronutrients’ French study group. International Journal of Epidemiology 22, 761-771.

Mannino DM, Buist AS, Petty TL, Enright PL, Redd SC. 2003. Lung function and mortality in the United States: data from the First National Health and Nutrition Examination Survey follow up study Thorax 58, 388-393.

Naidoo RN, Robins TG, Solomon A, White N, Franzblau A. 2004. Radiographic outcomes among South African miners. International Archives of Occupational and Environmental Health 77, 471-481.

Niculescu T, Dumitru R, Burnea D. 1981. Changes of copper, iron and zinc in the serum of patients with silicosis, silico-tuberculosis and active lung tuberculosis. Environmental Research 25, 260-268.

Pandey JK, Agarwal D. 2012.Biomarkers: A potential prognostic tool for silicosis. Indian Journal of Occupational and Environmental Medicine 16, 9-15.

Pelclova D, Fenclova Z, Kacer P, Navratil T, Kuzma M, Lebedova JK, Klusackova P. 2007. 8-Isoprostane and leukotrienes in exhaled breath condensate in Czech subjects with silicosis. Industrial Health 45, 766-774.

Ren ML, Jiang XL. 1993. Detection of coal silicosis by radioimmunoassay used for ceruloplasmin. Chinese Journal of Industrial Hygiene and Occupational Diseases 11,145-146.

Tiwari RR, Sathwara NG, Saiyed HN.2004. Silica exposure and serum copper: a cross sectional study. Indian Journal of Physiology and Pharmacology 48, 337-342.

Townsend M, Eschenbacher W, Beckett W, Bohnker B, Brodkin C, Cowl C. 2011. ACOEM Guidance Statement: Spirometry in the Occupational Health Setting. Journal of Occupational and Environmental Medicine 53, 569-584.

Tsuda T, Mino Y, Babazono A, Shigemi J, Otsu T, Yamamoto E, Kanazawa S. 2002. A case-control study of lung cancer in relation to silica exposure and silicosis in a rural area in Japan. Annals of Epidemiology 12, 288-294.

Wang W, Wang L, Yiwen L. 1998. Serum concentrations of copper and Zinc in patients with silicosis. Journal of Occupational Health 40, 230-231

Yoshida D, Ikeda Y, Nakazawa S. 1993. Quantitative analysis of copper, zinc and copper/zinc ratio in selected human brain copper, zinc and copper/zinc ratio in selected human brain tumors. Journal of Neuro-Oncology 16, 109-115.

Yucel I, Arpaci F, Ozet A, Doner B, Karayilanoglu T, Sayar A, Berk O. 1994. Serum copper and zinc levels and copper/zinc ratio in patients with breast cancer. Biological Trace Element Research 40, 31-38.


Style Switcher

Select Layout
Chose Color
Chose Pattren
Chose Background