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Research Paper | February 1, 2011

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Serum ghrelin response to long-term regular exercise is not related to dynamic lung volumes in mild to moderate asthma

Eizadi Mojtaba, Shahgholiabasi Rose, Iranshahi Farzaneh, Daraei Shokrabad Firooz

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Int. J. Biosci.1(1), 70-81, February 2011

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Abstract

Ghrelin, a 28-amino-acid peptide, is known to be associated with obesity and diabetes, although no direct evidence is currently available regarding its role in asthma. The purpose of this study was to compare serum ghrelin between sedentary adult men with mild to moderate asthma (n=28) and healthy (n=15) subjects matched for age (38 ± 6 year), height (174 ± 7 cm) and BMI (32 ± 5.2 kg/m2) that participated in this study By accessible sampling. Asthma patients were divided into experimental (exercise) and control (no training) groups by randomly. At first, fating blood samples were collected in asthma and none-asthma participant in order to comparing serum ghrelin between them. Blood samples were repeated in experimental and control groups of asthma patients after an aerobic exercise program (60 min, 3 days/week for 3 months) for determine serum ghrelin response to exercise training. Spirometry test was performed before and after exercise program in two asthmatic groups. Statistical analysis was performed with the SPSS software version 15.0 using an independent paired t-test. At baseline, serum ghrelin levels were significantly higher in asthma patients in comparison to healthy subjects. Compared to pre-training, the ghrelin levels decreased (P<0.01) and respiratory functional increased (p˂0.05) significantly after exercise program in the experimental but not in the control groups. There were no correlations between serum ghrelin concentrations and spirometry markers in baseline or after exercise training in patients (p≥0.05). Based on this data, it was concluded that although aerobic exercise training affects bout serum ghrelin and respiratory functional in asthmatic patients, but baseline relationship between them and their responses to exercise are independent of each other.

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Serum ghrelin response to long-term regular exercise is not related to dynamic lung volumes in mild to moderate asthma

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