Serum ghrelin response to long-term regular exercise is not related to dynamic lung volumes in mild to moderate asthma

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Research Paper 01/02/2011
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Serum ghrelin response to long-term regular exercise is not related to dynamic lung volumes in mild to moderate asthma

Eizadi Mojtaba, Shahgholiabasi Rose, Iranshahi Farzaneh, Daraei Shokrabad Firooz
Int. J. Biosci.1( 1), 70-81, February 2011.
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Ghrelin, a 28-amino-acid peptide, is known to be associated with obesity and diabetes, although no direct evidence is currently available regarding its role in asthma. The purpose of this study was to compare serum ghrelin between sedentary adult men with mild to moderate asthma (n=28) and healthy (n=15) subjects matched for age (38 ± 6 year), height (174 ± 7 cm) and BMI (32 ± 5.2 kg/m2) that participated in this study By accessible sampling. Asthma patients were divided into experimental (exercise) and control (no training) groups by randomly. At first, fating blood samples were collected in asthma and none-asthma participant in order to comparing serum ghrelin between them. Blood samples were repeated in experimental and control groups of asthma patients after an aerobic exercise program (60 min, 3 days/week for 3 months) for determine serum ghrelin response to exercise training. Spirometry test was performed before and after exercise program in two asthmatic groups. Statistical analysis was performed with the SPSS software version 15.0 using an independent paired t-test. At baseline, serum ghrelin levels were significantly higher in asthma patients in comparison to healthy subjects. Compared to pre-training, the ghrelin levels decreased (P<0.01) and respiratory functional increased (p˂0.05) significantly after exercise program in the experimental but not in the control groups. There were no correlations between serum ghrelin concentrations and spirometry markers in baseline or after exercise training in patients (p≥0.05). Based on this data, it was concluded that although aerobic exercise training affects bout serum ghrelin and respiratory functional in asthmatic patients, but baseline relationship between them and their responses to exercise are independent of each other.


Aggarwal BB. 2003. Signalling pathways of the TNF superfamily: a double-edged sword. Nat. Rev. Immunol. 3, 745–756.

Aronson D, Roterman I, Yigla M, Kerner A, Avizohar O, Sella R. 2006. Inverse association between pulmonary function and C-reactive protein in apparently healthy subjects. American journal of respiratory and critical care medicine’s 174(6), 626-32.

Baek HS, Kim YD, Shin JH, Kim JH, Oh JW, Lee HB. 2011. Serum leptin and adiponectin levels correlate with exercise-induced bronchoconstriction in children with asthma. Ann Allergy Asthma Immunol 107(1), 14-21.

Barazzoni R, Bosutti A, Stebel M. 2005. Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle. Am J Physiol Endocrinol Metab 288, 228-235.

Broglio F, Arvat E, Benso A, Gottero C, Muccioli G, Papotti M. 2001. Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J Clin Endocrinol Metab 86, 5083–5086.

Broglio F, Gianotti L, Destefanis S. 2004. The endocrine response to acute ghrelin administration is blunted in patients with anorexia nervosa, a ghrelin hypersecretory state. Clin Endocrinol (Oxf) 60, 592-599.

Busse WW, Lemanske RF. 2001. Asthma. N. Engl. J. Med. 344, 350–362.

Date Y, Kojima M, Hosoda H. 2000. Ghrelin, a novel growth hormone- releasing alcylated peptide is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141, 4255–4261.

Date Y, Nakazato M, Hashiguchi S. 2002. Ghrelin is present in pancreatic ß- cells of humans and rats and stimulates insulin secretion. Diabetes 51, 124-9.

Eker S, Ayaz L, Tamer L, Ulubas B. 2010. Leptin, visfatin, insulin resistance, and body composition change in chronic obstructive pulmonary disease. Scand J Clin Lab Invest 70(1), 40-4.

Gupta P. 2008. Asthma in the obese: yet another reason to lose weight. Lung India 25(1), 1-3.

Kelishadi R, Hashemipour M, Mohammadifard N, Alikhassy H, Adeli K. 2008. Short- and long-term relationships of serum ghrelin with changes in body composition and the metabolic syndrome in prepubescent obese children following two different weight loss programs. Clin Endocrinol (Oxf) [Epub ahead of print].

Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. 1999. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402, 656– 660.

Luo FM, Liu XJ, Li SQ, Wang ZL, Liu CT, Yuan YM. 2005. Circulating ghrelin in patients with chronic obstructive pulmonary disease. Nutrition 21(7-8), 793-8.

Nagel  G,  Koenig  W,  Rapp  K,  Wabitsch  M,  Zoellner  I,  Weiland  SK.  2008. Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren. Pediatr Allergy Immunol [Epub ahead of print].

Nayak BS, Ramsingh D, Gooding S, Legall G, Bissram S, Mohammed A. 2010. Plasma adiponectin levels are related to obesity, inflammation, blood lipids and insulin in type 2 diabetic and non-diabetic Trinidadians. Prim Care Diabetes [Epub ahead of print].

Neveu WA, Allard JB, Dienz O, Wargo MJ, Ciliberto G, Whittaker LA et al. 2009. IL-6 Is Required for Airway Mucus Production Induced by Inhaled Fungal Allergens. J Immunol 183(3), 1732-8.

Pedersen   BK,   Hoffman-Goetz   L.    2000.    Exercise   and   the   immune   system: regulation, integration, and adaptation. Physiol Rev 80, 1055–1081.

Peng M, Cai BQ, Ma Y, Zhu HJ, Sun Q, Song AL. 2007. Circulating leptin and ghrelin in patients with chronic obstructive pulmonary disease. Zhonghua Jie He He Hu Xi Za Zhi 30(3), 182-5.

Sahoo RC, Acharya PR, Noushad TH, Anand R, Acharya VK, Sahu KR. 2009. A Study of High-Sensitivity C-Reactive Protein in Bronchial Asthma. Indian journal of chest diseases & allied sciences 51(4), 213-6.

Schroeder EB, Welch VL, Couper D, Nieto FJ, Liao D, Rosamond WD et al. 2003. Lung function and incident coronary heart disease: the Atherosclerosis Risk in Communities Study. Am J Epidemiol 158, 1171–1181.