J. Bio. Env. Sci.2(9), 80-85, September 2012
Recent evidence suggests the importance of molecules secreted by mast cell in diabetes. This study’s purpose was to determine whether serum Immunoglobulin E is associated with glycated hemoglobin and insulin resistance in human with diabetic mellitus. For this purpose, fasting serum Immunoglobulin E, glycated hemoglobin and insulin resistance were measured in forty five sedentary adult males (age 41±6 yrs, body weight 95±12 Kg) with diabetic mellitus. Pearson correlation coefficients were used to determine the associations between IgE with HbA1C and insulin resistance. A p-value less than 0.05 were considered statistically significant. A significant positive correlation was found between serum Immunoglobulin E with glycated hemoglobin (P= 0.000, r = 0.68). Serum Immunoglobulin E was also correlated positively with insulin resistance in studied patients (P= 0.000, r = 0.56). Based on high correlation in IgE with insulin resistance and HbA1C, It can be concluded that mast cell– related molecules can be affect pre-diabetes and diabetes mellitus, although more research is needed to further explore the physiopathological mechanisms underlying these associations.
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