Serum interleukin -1 beta in relation to cardiorespiratory fitness and anthropometry on obese and overweight women

Paper Details

Research Paper 01/07/2014
Views (188) Download (5)

Serum interleukin -1 beta in relation to cardiorespiratory fitness and anthropometry on obese and overweight women

Alinoori Fariba, Maryam Husseini Shakib, Leila Husseini
J. Bio. Env. Sci.5( 1), 664-669, July 2014.
Certificate: JBES 2014 [Generate Certificate]


Epidemiologic studies clearly show that obesity and sedentary is associated with low physical fitness. The purpose of this study was to analyze whether cardiorespiratory fitness (CRF) and obesity determinants are associated with serum IL-1ß as inflammatory cytokine in women with obesity or overweight. For this purpose, forty sedentary healthy overweight/obese women, 38 ± 4.2 year-olds were participated in this study by accessible sampling. Serum IL-1ß was measured after an overnight fast. Anthropometry, resting and submaximal heart rate and maximal oxygen consumption (VO2max) were measured by standard cycling test. Pearson correlation coefficients were used to determine the associations between VO2max with other variables. A p-value less than 0.05 were considered statistically significant. Analysis data showed no significant correlation in VO2max with all anthropometrical markers. Serum IL-1ß was not correlated with VO2max, anthropometrical markers, resting and submaximal heart rate. Based on these data, it’s concluded that cardiorespiratory fitness is not directly correlated with inflammation in obese or overweight women. Further studies are necessary to elucidate mechanisms underlying by which inflammation affect physical fitness in this population.


Balducci S, Zanuso S, Nicolucci A, Fernando F, Cavallo S, Cardelli P. 2009. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutrition, Metabolism & Cardiovascular Diseases. [Epub ahead of print].

Bruun JM, Lihn AS, Verdich C, Pedersen SB, Toubro S, Astrup A, Richelsen B. 2003. Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. American Journal of Physiology – Endocrinology and Metabolism 285, 527–33.

Cicchella A1, Stefanelli C, Purge P, Lätt E, Saar M, Jürimäe T. 2013. The associations between peak O2 consumption and leptin in 10- to 12-year-old boys. Clinical Physiology and Functional Imaging’s 33(4), 313-6.

Dilyara G, Yanbaeva, Mieke A, Dentener, Eva C, Creutzberg, Geertjan Wesseling, Emiel F. M. Wouters. 2007. Systemic Effects of Smoking. ccChest 4, 1557-1566.

Dinarello CA. 2009. Immunological and inflammatory functions of the interleukin-1 family. Annual Review of Immunology 27, 519–550.

Gery I, Waksman BH. 1972. Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s). Journal of Experimental Medicine 136, 143–155.

Hammett CJ, Prapavessis H, Baldi JC, Varo N, Schoenbeck U, Ameratunga R. 2006. Effects of exercise training on 5 inflammatory markers associated with cardiovascular risk. American Heart Journal 151(2), 367-76.

Kaplan NM. 2002. Hypertension and diabetes. Journal of Human Hypertension 16(Suppl 1), 56-60.

Kline GM. 1989. Estimation of VO2max from a one-mile track walks, gender, age, and body weight. Medicine and Science in Sports and Exercise 19, 253-259.

Klöting N, Fasshauer M, Dietrich A, Kovacs P, Schön MR, Kern M. 2010. Insulin sensitive obesity. American Journal of Physiology- Endocrinology and Metabolism [Epub ahead of print].

Maedler K, Dharmadhikari G, Schumann DM, Størling J. 2009. Interleukin-1 beta targeted therapy for type 2 diabetes. Expert Opinion on Biological Therapy 9(9), 1177-88.

Maedler K, Sergeev P, Ris F. 2002. Glucose- induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. Journal of Clinical Investigation 110, 851–860.

Okamoto M, Liu W, Luo Y. 2010. Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta. Journal of Biological Chemistry 285, 6477–6488.

Okita K, Nishijima H, Murakami T, Nagai T, Morita N, Yonezawa K. 2004. Can exercise training with weight loss lower serum C-reactive protein levels? Arterioscler Thrombosis Vascular Biology 24(10), 1868-73.

Osborn O, Brownell SE, Sanchez-Alavez M, Salomon D, Gram H, Bartfai T. 2008. Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity. Cytokine 44(1), 141-8.

Ozen S, Bilginer Y, Aktay Ayaz N, Calguneri M. 2011. Antiinterleukin 1 treatment for patients with familial Mediterranean fever resistant to colchicine. Journal of Rheumatology 38, 516–518.

Quartier P, Allantaz F, Cimaz R. 2011. A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial). Annals of the Rheumatic Diseases 70, 747–754.

Schumacher Jr HR, Sundy JS, Terkeltaub R. 2012. Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: results of a phase II randomized, double-blind, placebo-controlled trial. Arthritis & Rheumatology 64, 876–884.

Sigal RJ, Kenny GP, Wasserman DH, Castaneda-Sceppa C, White RD. 2006. Physical activity/exercise and type 2 diabetes: a consensus statement from the American diabetes association. Diabetes Care 29, 1433–1438.

Utsal L, Tillmann V, Zilmer M, Mäestu J, Purge P, Saar M, Lätt E, Maasalu K, Jürimäe T, Jürimäe J. 2013. Negative correlation between serum IL-6 level and cardiorespiratory fitness in 10-to 11-year-old boys with increased BMIPediatric Endocrinology and Metabolism 26(5-6), 503-8.

Varady KA, Tussing L, Bhutani S, Braunschweig CL. 2009. Degree of weight loss required to improve adipokine concentrations and decrease fat cell size in severely obese women. Metabolism 58(8), 1096-101.

Varra JP, Fogelholm M, Vasankari T, Hakkinen K, Santtila M, Kyrolanen H. 2012. Associations of cardiorespiratory and muscular fitness with IL-6 and TNF concentrations in normal and overweight young men. Acta Physiologica 206(691), 59.