Serum interleukin-1 beta plays an important role in insulin secretion in type II diabetic

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Research Paper 01/06/2011
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Serum interleukin-1 beta plays an important role in insulin secretion in type II diabetic

Eizadi Mojtaba, Kohandel Mahdi, kasbparast JR Mehdi, Sarshin Amir
Int. J. Biosci.1( 3), 93-99, June 2011.
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The proinflammatory cytokine Interleukin-1beta is increased in presence obesity or its related disorders. The objective of this study was to determine serum IL-1β in relation to some markers indicative of type II diabetic. For this purpose, blood samples were collected from brachial vein after a overnight fast between 8:00 and 9:00 a.m. o’clock in order to measuring serum IL-1β, glucose, insulin and beta cell function in a group of type II diabetic men patients (n = 30) and none-diabetic healthy subjects (n = 36) matched for BMI and age in order 1) to compare serum IL-1b between diabetic and none-diabetic subjects, 2) to determine serum IL-1b in relation to fasting glucose, insulin and beta-cell function in diabetic patients. All anthropometrical indexes were also measured in two groups. Statistical analysis was performed by Independent sample T-test and Spearman rank correlation method. P value of <0.05 was accepted as significant. Insulin resistance and fasting glucose and serum IL-1b were significantly higher and serum insulin and Beta cell function were significantly lower in diabetic patients than none-diabetic subjects (p < 0.05). Serum IL-1b was negatively correlated with insulin and beta cell function and positively related with fasting glucose in diabetic patients (p < 0.05). Based on this data, it was concluded that IL-1b as a inflammation cytokine play a important role in type II diabetic and insulin secretion of pancreatic beta cell.


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