Serum interleukin-1beta and lipid profile responses to aerobic training in obese men
Paper Details
Serum interleukin-1beta and lipid profile responses to aerobic training in obese men
Abstract
Obesity is known to be associated with systemic inflammation. To investigate serum IL-1B and lipid profile responses to aerobic exercise program. A total thirty four sedentary adult obese men aged 38-43 years were selected to participate in study and divided to exercise and control group by randomly. The participants of exercise group were completed an aerobic exercise program for 3 months (3 days/weekly) and control group were banned of exercise in this period. Pre and post exercise training of serum IL-1β, lipid profile markers and anthropometrical indexes were measured in two groups. Statistical analysis was performed by independent and paired T test (p ≤ 0.05). No significant differences were found in anthropometrical and biochemical parameters between 2 groups at baseline. Despite of a significant decrease in all anthropometrical parameters, but serum IL-1β concentration did not change significantly after aerobic program when compared to baseline data. Triglyceride concentration was decreased significantly with exercise training whereas concentrations of TC, HDL cholesterol, and LDL cholesterol did not change. Based on these data, it seems that if aerobic exercise does not improve lipid profile blood lipid levels in obese subjects it does not cause any change in the levels IL-1B an inflammatory cytokine.
Baum M, Klöpping-Menke K, Müller-Steinhardt M, Liesen H, Kirchner H. 1999. Increased concentrations of interleukin 1-beta in whole blood cultures supernatants after 12 weeks of moderate endurance exercise. Eur J Appl Physiol Occup Physiol 79(6), 500-3.
Böni-Schnetzler M, Thorne J, Parnaud G, Marselli L, Ehses JA, Kerr-Conte J. 2008. Increased interleukin (IL)-1β messenger ribonucleic acid expression in β-cells of individuals with type 2 diabetes and regulation of IL-1β in human islets by glucose and autostimulation. J Clin Endocrinol Metab 93(10), 4065-74.
Charles L, Nicole W, Brian F, Dennis V. 2008. Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons. J Appl Physiol 105, 473–478.
Eizadi M, Khorshidi D, Seyedhoseini MA, Dooaly H. 2011. Increased interleukin-1 beta is associated with high fasting glucose in obese men. International Journal of Biosciences 1(6), 141-146.
Gielen S, Adams V, Mobius-Winkler S, Linke A, Erbs S, Yu J. 2003. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol 42, 861–868.
Greiwe JS, Cheng B, Rubin DC, Yarasheski KE, Semenkovich CF. 2001. Resistance exercise decreases skeletal muscle tumor necrosis factor alpha in frail elderly humans. FASEB J 15, 475– 482.
Grimble RF. 2003. Inflammatory response in the elderly. Curr Opin Clin Nutr Metab Care 6, 21–29.
Juge-Aubry CE, Somm E, Chicheportiche R, Burger D, Pernin A, Cuenod-Pittet B. 2004. Regulatory effects of interleukin (IL)-1, interferon-_, and IL-4 on the production of IL-1 receptor antagonist by human adipose tissue. J Clin Endocrinol Metab 89, 2652–2658.
Koenig W, Khuseyinova N, Baumert J. 2006. Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. Arterioscler Thromb Vasc Biol 26, 2745 -51.
Larsen AI, Aukrust P, Aarsland T, Dickstein K. 2001. Effect of aerobic exercise training on plasma levels of tumor necrosis factor alpha in patients with heart failure. Am J Cardiol 88, 805– 808.
LeMaitre JP, Harris S, Fox KA, Denvir M. 2004. Change in circulating cytokines after 2 forms of exercise training in chronic stable heart failure. Am Heart J 147, 100–105.
Maedler K, Dharmadhikari G, Schumann DM, Størling J. 2009. Interleukin-1 beta targeted therapy for type 2 diabetes. Expert Opin Biol Ther 9(9), 1177-88.
Manica-Cattani MF, Bittencourt L, Rocha MI, Algarve TD, Bodanese LC, Rech R et al. 2010. Association between interleukin-1 beta polymorphism (+3953) and obesity. Mol Cell Endocrinol 314(1), 84-9.
Manica-Cattani MF, Bittencourt L, Rocha MI, Algarve TD, Bodanese LC, Rech R. 2010. Association between interleukin-1 beta polymorphism (+3953) and obesity. Mol Cell Endocrinol 15, 314(1), 84-9.
Markovic O, O’Reilly G, Fussell HM. 2004. Role of single nucleotide polymorphisms of proinflammatory cytokine genes in the relationship between serum lipids and inflammatory parameters, and the lipid-lowering effect of fish oil in healthy males. Clin Nutr 23, 1084–95.
Martin-Cordero L, Garcia JJ, Giraldo E, De la Fuente M, Manso R, Ortega E. 2009. Influence of exercise on the circulating levels and macrophage production of IL-1beta and IFNgamma affected by metabolic syndrome: an obese Zucker rat experimental animal model. Eur J Appl Physiol 107(5), 535-43.
Maruyama Y, Nordfors L, Stenvinkel P. 2005. Interleukin-1 gene cluster polymorphisms are associated with nutritional status and inflammation in patients with end-stage renal disease. Blood Purif 23, 384–93.
Matsuki T, Horai R, Sudo K, Iwakura Y. 2003. IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions. J Exp Med 198(6), 877-88.
Nicklas BJ, Ambrosius W, Messier SP, Miller GD, Penninx BW, Loeser RF, Palla S, Bleecker E, Pahor M. 2004. Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial. Am J Clin Nutr 79, 544–551.
Saghizadeh M, Ong JM, Garvey WT, Henry RR, Kern PA. 1996. The expression of TNF alpha by human muscle. Relationship to insulin resistance. J Clin Invest 97, 1111–1116.
Trayhurn P, Wood IS. 2004. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J. Nutr. 92, 347–355.
Um JY, Chung HS, Song MY, Shin HD, Kim HM. 2004. Association of interleukin-1beta gene polymorphism with body mass index in women. Clin Chem 50, 647–650.
Wellen KE, Hotamisligil GS. 2005. Infl ammation, stress, and diabetes. J Clin Invest 115, 1111 -19.
White LJ, Castellano V, McCoy SC. 2006. Cytokine responses to resistance training in people with multiple sclerosis. J Sports Sci 24, 911–914.
Eizadi Mojtaba, Zand Alireza, Faraji Gholamreza, Parsian Heshmatolah, 2012. Serum interleukin-1beta and lipid profile responses to aerobic training in obese men. J. Biodiv. Environ. Sci., 2(6), 60-66.
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