home icon user icon
Welcome to International Network for Natural Sciences | INNS Pub.
Home My Account
Submit Manuscript
double_slash
breadcumb_bg

Serum lipid stabilising effect of sarabat (Diplazium asperum Blume) aqueous extract in diet-induced hyperlipidemic wistar albino rats

Paper Details

Research Paper 01/04/2022
Views (365) Download (47)
current_issue_feature_image
publication_file

Serum lipid stabilising effect of sarabat (Diplazium asperum Blume) aqueous extract in diet-induced hyperlipidemic wistar albino rats

Pablo M. Afidchao Jr., Michael B. Ples
Int. J. Biosci.20( 4), 97-105, April 2022.
Certificate: IJB 2022 [Generate Certificate]
Key: CholesterolDiplazium asperum Bl.Hyperlipidemialipid profileSaponins

Abstract

Hyperlipidemia remains an important modifiable risk factor in cardiovascular diseases. The aim of the present study was to investigate the potential role of the aqueous decoction of Sarabat (Diplazium asperum Blume) in lowering plasma lipid profile in albino rats fed a high-fat diet (HFD). Thirty Wistar albino rats were randomly divided into five groups of six rats and, for 42 days, were administered plain water and standard pellets (negative controls), lard and cholesterol (hypercholesterolemic animals), low and high dose Sarabat decoction (1 and 2 g/100ml water respectively) and Simvastatin as a positive control. The effects of D. asperum Bl. (Sarabat) decoction on rat lipid profiles was assessed by measuring the plasma Total cholesterol (TC), triglyceride (TG), Low-density Lipoprotein (LDL), High-Density Lipoprotein (HDL) and Very Low-Density Lipoprotein (VLDL). Administration of lard and cholesterol showed gradual elevation of total cholesterol and similarly for the other lipid parameters with an increasing lipid profile after a two-week metabolic adjustment period. Concurrent administration of Sarabat (D. asperum Bl.) decoction showed a promising decrease in total cholesterol serum concentration (p<0.006), and an increase in High-Density Lipoprotein (HDL) was notable. These findings suggest the cholesterol and lipid buffering or modulating effects of saponin-rich Sarabat as potentially useful in the management of hyperlipidemia as part of diet therapy.

VIEWS 62
Cover PDF

Akdogan M, Koyu A, Ciris M, Yidiz K. 2012. Anti-hypercholersterolemic Activity of Juniperus communis Linn oil in Rats: a biochemical and histopathological investigation. BioMed Research 23, 321-328.

Baron RB. 2018. Lipid Disorders, Current Medical Diagnosis and Treatment, chp.28.

Chai TT, Elamparuthi S, Yong AL, Quah Y, Ong HC, Wong FC. 2013. Antibacterial, anti-glucosidase, and antioxidant activities of selected highland ferns of Malaysia. Botanical Studies 54(1), BioMed Research 23, 321-328.

Chai TT, Kwek MT, Ong HC, Wong FC. 2015. Water fraction of edible medicinal fern Stenochlaena palustris is a potenta-glucosidase inhibitor with concurrent antioxidant activity. Food Chemistry 186, 26–31.

Chai TT, Panirchellvum E, Ong HC, Wong FC. 2012. Phenolic contents and antioxidant properties of Stenochlaena palustris, an edible medicinal fern. Botanical Studies 53(4), 439–446.

Chattopadhyaya R, Pathak D, Jindal DP. 1996. Anti-hyperlipidemic agents. A review. Ind Drugs 3, 85–98.

Dahanukar SA, Kulkarni RA, Rege NN. 2000. Pharmacology of medicinal plants and natural products. Indian Journal of Pharmacology 32, 81-118.

Ecobichon DJ. 1997. The Basis of Toxicology Testing. New York, CRC Press 43–86.

Ghule BV, Ghante MH, Saoji AN, Yeole PG. 2006. Hypolipidemic and anti-hyperlipidemic effects of Lagenariasi ceraria (Mol) fruit extracts. Indian Journal of Experimental Biology 4, 905-909.

Gumaraes PR, Galavao AMP, Batista CM.  2000. Eggplant (Solanum melongena) infusion has modest and transitory effect on hyper cholesterolemic subjects. Brazilian Journal of Medical and Biological Research 33, 1027.

Kaup RS, Arunkumar N, Bernhardt LK, Vasavi RG, Shetty SS, Pai SR, Arunkumar B. 2011. Antihyperlipedemic activity of Cynodon dactylon extract in high-cholesterol diet fed Wistar rats. Genomic Medicine, Biomarkers, and Health Sciences 3, 98-102.

Kuppusamy P, Raj RS, Ilavenil S, Kaleeswaran B, Govindan N, Maniam GP, Ravikumar S. 2015. Evaluation of antihypercholesterolemic effect using Meme cylonedule Roxb. ethanolic extract in cholesterol-induced Swiss albino mice. Journal of Acute Medicine 5, 85-91.

Leontowicz H, Gorinstein S, Lojek A, Leontowicz M, Ciz M, Soliva-Fortuny R. 2002. Comparative content of some bioactive compounds in apples, peaches, and pears and their influence on lipids and antioxidant capacity in rats. Journal of Nutrition Biochemistry 13, 603–610.

Lusis AJ. 2008. Review article. Atherosclerosis. Nature 407, 233–241.

Malloy MJ, Kane JP. 2012. Used in Dyslipidemia; Katzung B.G. et al, Basic and Clinical Pharmacology 12th edition Mc Graw Hill Co.

Matsui Y, Kobayashi K, Masuda H. 2009. Quantitative analysis of saponins in a tea leaf extract and their antihypercholesterolemic activity. Biosci Biotechnol Biochem 73, 90003-90007.

Odinga T, Essien EB, Akaninwor JO. 2020. Anti-hyperlipidemic potency of the seed extract of Ricinodendron heudelotii in Wistar Alnino Rats. Asian J.Biol.Sci 13, 341-345.

Pendurkar SR, Mengi SA. 2009. Anti-hyperlipidemic effect of aqueous extract of Plumbagozey lanicaroots in diet-induced hyperlipidemic rat. Pharmaceutical Biology 47(10), 1004-1010.

Rupasinghe HP, Jackson CJ, Poysa V. DiBerado C, Bewely JD, Jenkinson J. 2003. Soyasapogenol A and B distribution in Soybean (Glycine max L. Merr) in relation to seed physiology, genetic variability and growing location. Journal of Agricultural and Food Chemistry 51, 5888-5894.

Scartezzini P, Speroni E. 2000. Review on some plants of Indian traditional medicine with antioxidant activity. Journal of Ethnopharmacology 71, 23-43.

Sidhu GS, Oakenful DG. 1990. Could saponins be a useful treatment for hypercholesterolemia?. European Journal of Clinical Nutrition 44, 79.

Singh RB, Mengi S, Xu YJ, Arneja AS, Dhalla NS. 2002. Pathogenesis of atherosclerosis: A multifactorial process. Experimental & Clinical Cardiology 7, 40–53.

Tongco JV, Villaber RAP, Aguda RM, Razal R. A. 2014. Nutritional and phytochemical screening, and total phenolic and flavonoid content of Diplazium esculentum (Retz.) Sw. from Philippines. Journal of Chemical and Pharmaceutical Research  6(8), 238-242.

Wei HA, Lian TW, Tu YC, Hong JT, Kou MC, Wu MJ. 2007. Inhibition of low-density lipoprotein oxidation and oxidative burst in polymorpho nuclear neutrophils by caffeic acid and hispidin derivates isolated from sword brake ferns (Pterisensi formis Burm.). Journal of Agricultural and Food Chemistry 55, 10579-10584.

Submit Manuscript