Serum TNF-a response to an acute bout of exercise in middle-aged men with chronic asthma

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Short Communications 01/04/2013
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Serum TNF-a response to an acute bout of exercise in middle-aged men with chronic asthma

Sohaily Shahram, Shafabakhsh Sayyed Rafi, Kaboli Mohamadzaman, Parsian Heshmatolah
J. Bio. Env. Sci.3( 4), 102-106, April 2013.
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In order to investigate whether short term exercise test can lead to improve inflammatory state, fifteen middle-aged men with mild to moderate asthma with mean age 39.6 ± 7.9 years (mean+/-s.e.m.) were enrolled to participate in this study by accessible sampling. For this purpose, blood samples were collected before and immediately after a cycling exercise test in order to determine serum TNF-α response to exercise test in studied subjects. Student’s t-tests for paired samples were performed to determine whether there is a signigcant change in the outcomes. The data showed a significant decrease in serum TNF-α by exercise test when compared to pre-test. Based on this data, we conclude that moderate exercise even one session cycling for short-time can be improved systemic inflammation in asthma patients.


Adner M, Rose AC, Zhang Y. 2002. An assay to evaluate the long-term effects of inflammatory mediators on murine airway smooth muscle: evidence that TNFalpha up-regulates 5-HT(2A)-mediated contraction. British Journal of Pharmacology 137(7), 971-82.

Aldhahi W, Hamdy O. 2003. Adipokines, inflammation, and the endothelium in diabetes. Current Diabetes Reports 3(4), 293-8.

Bradding P, Roberts JA, Britten KM. 1994. Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. American Journal of Respiratory Cell and Molecular Biology 10(5), 471-80.

Brightling CE, Bradding P, Symon FA, Holgate ST, Wardlaw AJ, Pavord ID. 2002. Mast-cell infiltration of airway smooth muscle in asthma. New England Journal of Medicine 346(22), 1699-705.

Coward WR, Okayama Y, Sagara H, Wilson SJ, Holgate ST, Church MK. 2002. NF-kappa B and TNF-alpha: a positive autocrine loop in human lung mast cells? Journal of Immunolojy 169(9), 5287-93.

Eizadi Mojtaba, Kohandel Mehdi, kasbparast JR Mehdi, Sarshin Amir. 2011. Hs-CRP and TNF-alpha in response to a stepwise incremental bicycle test in adult obese men. Journal of Biodiversity and Environmental Sciences 1(3), 35-43.

Hammett CJ, Prapavessis H, Baldi JC, Varo N, Schoenbeck U, Ameratunga R. 2006. Effects of exercise training on 5 inflammatory markers associated with cardiovascular risk. American Heart Journal 151(2), 367-70.

Huang H, Iida KT, Sone H, Ajisaka R. 2007. The regulation of adiponectin receptors expression by acute exercise in mice. Experimental and Clinical Endocrinology & Diabetes 115(7), 417-22.

Jung SH, Park HS, Kim KS, Choi WH, Ahn CW, Kim BT. 2008. Effect of weight loss on some serum cytokines in human obesity: increase in IL-10 after weight loss. Journal of Nutritional Biochemistry 19(6), 371-5.

Kips JC, Tavernier J, Pauwels RA. 1992. Tumor necrosis factor causes bronchial hyperresponsiveness in rats. American Review of Respiratory Disease 145, 332–336.

Meyer A, Wendt G, Taube K, Greten H. 1997. Ambulatory sports in asthma improve physical fitness and reduces asthma-induced hospital stay. Pneumologie journal 51(8), 845-9.

Mullis R, Campbell IT, Wearden AJ, Morriss RK, Pearson DJ. 1999. Prediction of peak oxygen uptake in chronic fatigue syndrome. British Journal of Sports Medicine 33(5), 352-6.

Ramazanoglu YM, Kraemer R. 1985. Cardiorespiratory response to physical conditioning in children with bronchial asthma. Pediatric Pulmonology 1(5), 272-7.

Sheu WH, Chang TM, Lee WJ, Ou HC, Wu CM, Tseng LN. 2008. Effect of weight loss on proinflammatory state of mononuclear cells in obese women. Obesity (Silver Spring) 16(5), 1033-8.

Thomas PS, Heywood G. 2002. Effects of inhaled tumour necrosis factor alpha in subjects with mild asthma. Thorax 57(9), 774-8.

Thomas PS, Yates DH, Barnes PJ. 1995. Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects. American Journal of Respiratory and Critical Care Medicine 152, 76–80.

Ying S, Robinson DS, Varney V. 1991. TNF alpha mRNA expression in allergic inflammation. Clinical & Experimental Allergy 21(6), 745-50.