Serum urea, uric acid and creatinine levels in diabetic mellitus patients attending Jos University Teaching Hospital, North central Nigeria

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Serum urea, uric acid and creatinine levels in diabetic mellitus patients attending Jos University Teaching Hospital, North central Nigeria

Ediale Joshua Richard, Adugba Oko Augustine, Celestine Okafor Ani, Paschal Uwadiegwu Chime, Uzoigwe Uzowulu Jide, Agu Uchenna Francis, Okorie Onyinye Pamela, Nworgu Choice Chinemerem, Adaobi Bisi Onyemaechi, Ebute Charles Paul
Int. J. Biosci.11( 4), 68-72, October 2017.
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Assay of Serum urea, uric acid and creatinine concentrations are important in the management of chronic diseases such as diabetes mellitus. Diabetes mellitus has an effect on the excretion of uric acid and creatinine in different sexes of diabetes mellitus (DM) patients attending Jos University Teaching Hospital (JUTH). This study also compared between urea, uric acid and creatinine concentration in the serum of diabetic (control group). 150 individuals were recruited for this study, seventy four (74) apparently healthy (non-diabetic) subjects were recruited as control and seventy six (76) diabetic subjects. The diabetic consist of thirty eight (38) male and thirty eight (38) females. The non diabetics consist of equal number of thirty seven (37) females and males respectively. The subjects were enlightened and given informed consents prior to the research. They were fasted overnight (12hr) and 5ml pre-prandial blood were collected from cubital vein in the arm the following morning with a sterile syringe, tourniquet and 75% alcohol and needle and the blood transferred to an Ethylenediaminetetraacetic acid (EDTA) bottle and kept at temperature of 20C and later analyzed. The result shows the level of serum (7.9±3.8) and creatinine (200±7.8) uMol/L significantly increased (p<0.05) in diabetic subjects. In male diabetic subjects the serum urea (7.4±3.2) uMol/l and creatinine (218±7.9) were significant. There was also a significant increase (p>0.05) in the female diabetic subjects. Though the serum uric acid level was higher in male diabetic (243±10.6) than the female diabetic (222±10.8), yet there was no significant difference (p>0.05). These values were also higher in male non-diabetic (179±8.4). This study therefore confirms that the assay of serum urea and creatinine concentrations have an important role in the management of diabetic mellitus patients.


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