Studies of the effects of aqueous extract of Garcinia kola on fatigue and memory in Wistar Rats

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Research Paper 09/08/2023
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Studies of the effects of aqueous extract of Garcinia kola on fatigue and memory in Wistar Rats

Augustin N’da Kouassi Kangah, Kakou Luc Gbalou, Seydou Silue, Rodrigue Bou, N’cho Arthur N’guessan, Léon Glin
Int. J. Biosci.23( 2), 264-276, August 2023.
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Abstract

The objective of this study is to evaluate the possible effects of the aqueous extract of Garcinia kola at the dose of 1000 mg/kg (EAGk) on the decrease of vigilance. This decrease in alertness is due to fatigue and memory impairment promoted by sleep deprivation for 7 consecutive days on wistar rats. 18 male rats aged 8 weeks weighing between 200 and 220g, divided into 3 groups of 6 rats, were subjected to sleep deprivation using a modified multiple platform. On the seventh day, the groups were subjected to different behavioral tests. It appears from our results that: In terms of fatigue, the analysis of the results of the openfield and the elevated cross labyrinth indicates that the rats treated with aqueous extract of Garcinia kola, present reduction of anxiety. The exhaustive nation test shows that the rats treated with aqueous extract of Garcinia kola have a good muscular performance. Regarding memory disorders, these rats treated with aqueous extract of Garcinia kola and deprived of sleep do not show any sign of memory impairment in the Y- labyrinth and objects recognition tests. In general, our results showed that the aqueous extract of Garcinia kola prevents the decrease in vigilance through its anxiolytic effects that eliminate anxiety and improves muscle performance but especially that allow increasing the learning capacity and the potential of memorization.

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