Welcome to International Network for Natural Sciences | INNSpub

Studies on the behavioral and clinical manifestation due to toxicity of some pyrethroid insecticides in male albino Rat, Rattus norvegicus (Berkenhout)

Research Paper | April 1, 2019

| Download 3

Nazia Khalil, Muhmmad Kashif Zahoor, Kausar Malik, Adnan Ahmad Qazi, Farhat Jabeen, Sumaira Parveen, Shumaila Saif, Sarfraz Hussain

Key Words:

Int. J. Biosci.14( 4), 409-417, April 2019

DOI: http://dx.doi.org/10.12692/ijb/14.4.409-417


IJB 2019 [Generate Certificate]


The current study was designed to evaluate the effects of some frequently used pyrethroid insecticides (Cypermethrin@ 0, 130,150 and 200mg/kg, Deltamethrin @0, 20, 25 and 30mg/kg, Permethrin@0, 150, 250 and 350mg/kg and Lambda Cyhalothrin @0, 30, 50 and 70mg/kg) on the behavior and clinical signs in albino rats, Rattus norvegicus underLab conditions. Feed intake, hind limb jerking, breathing problem, salivation, eye discharge, loss in body weight, lesion (internal organs), oedema, startle response, death were recorded at 7, 14 and 28 days of post application interval including a control (0-application of pyrethroid). The results revealed a reduction in feed intake and body weight against tested pyrethroid insecticides at all dose rates and post treatment intervals.


Copyright © 2019
By Authors and International Network for
Natural Sciences (INNSPUB)
This article is published under the terms of the Creative
Commons Attribution Liscense 4.0

Studies on the behavioral and clinical manifestation due to toxicity of some pyrethroid insecticides in male albino Rat, Rattus norvegicus (Berkenhout)

Adjrah Y, Karou SD, Agbonon A, Ameyapoh Y, De Souza C, Gbeassor M. 2013. Effect of cypermethrin treated lettuce (Lactuca sativa) on Wister rat liver. Journal Applied Pharmacolgical Sciences 39(1), 128-132.

Agriphar SA. 2010. Evaluation report according to Directive 98/8/EC of cypermethrin. Rapporteur Member State: Belgium 8, 10-15.

Ali A, Khan JA, Khaliq T, Javed I, Muhammad F, Aslam B, Khan Z. 2014. Hemato-Biochemical Disruptions by Lambda-cyhalothrin in Rats. Pak Veterinary Journal 34(1), 54-57.

Bhushan B, Saxena PN, Saxena N. 2013. Biochemical and histological changes in rat liver caused by cypermethrin and beta-cyfluthrin. Arch. Hig. RadaToksikol. 64(1), 57-67.

Elhalwagy ME, Abd-Alrahman SH, Nahas AA, Ziada RM, Mohamady AH. 2015. Hepatopancreatic intoxication of lambda cyhalothrin insecticide on albino rats. International Journal Clinical Expert Medical   8(5), 7297-7305.

Ibiang YB, Ekaluo UB, Nta AI, Ikpeme EV, Ekanem BE, Erem FA. 2013. Effect of deltamethrin and ridomil on serum biochemical parameters in the rat (Rattus norvegicus). Europe Journal Toxicological Sciences 5, 1-10.

Institoris L, Undeger U, Siroki O, Nehez M, Desi I. 1999. Comparison of detection sensitivity of immuno and genotoxicological effects of sub acute cypermethrin and permethrin exposure in rats. Toxicology 137, 47-5.

Iqbal MJ, Bollaert M, Chickris N, James B, Hig­ginbotham DA, Peterson R, Murphy L. 2007. Ginseng modifies the diabetic phenotype and genes as­sociated with diabetes in the male ZDF rat. Phytomedicine 14, 681-689.

Islam MS, Hoque MM. 2015. Clinico-haematological and histopathological features of the Swiss albino mice Musmusculus L. in response to chronic cypermethrin exposure. Scholar Academic Journal Biosciences 3(5), 421-428.

Kothari V, Stevens RJ, Adler AI, Stratton IM, Manley SE, Neil HA, Holman RR. 2002. Risk of stroke in type 2 diabetes estimated by the UK Prospective Diabetes Study risk engine Stroke 33, 1776-1781.

Kotli T, Yon ND. 2015. The effects of permethrin on rat ovarian tissue morphology. Expert Toxicological Pathology 67, 279285.

Lee DH, Lee IK, Song K, Steffes M, Toscano W, Baker B, Jacobs Dr Jr A. 2006. A strong dose-re­sponse relation between serum concentra­tions of persistent organic pollutants and dia­betes: results from the National Health and Examination Survey 1999-2002. Diabetes Care 29, 1638-1644.

Macan J, Varnai VM, Turk R. 2006. Health effects of pyrethrins and pyrethroids, Arh Hig Rada Toksiko 57, 237-43.

Madiha WMA, Mie MSG, Sally MSS, Zeinab AM. 2017. Study of Chronic Toxic Effect of Deltamethrin and Dimethoate On Brain Of Adult Male Albino Rats. Zagazig Journal of Forensic Medical & Toxicology 15, 1.

Mate MS, Ghosh RC, Mondal S, Karmakar DB. 2010. Effect of Lambda Cyhalothrin on Rats: An Acute Toxicity Study. JIST 06(01), 25-29.

Meister RT. 1992. Farm chemicals Handbook. Mister Pub. Co. Willoughby.

Mitchell RN, Kumar V, Abbas AK, Fausto N. 2006. Hemodynamic disorders, throb embolic diseases and shock. In Robbins and Cotran’s Pathologic Basis of Disease, 7th edn. Elsevier Publications, New Delhi, India 119-144.

Nair RR, Abraham MJ, Lalitha kunjamma CR, Nair ND, Aravindakshan CM. 2011. A pathomorphological study of the sublethal toxicity of cypermethrin in Sprague Dawley rats. International Journal Nutrition Pharmacology Neurological Disease 1(2), 179-183.

O’malley M. 1997. Clinical evaluation of pesticide exposure and poisonings, Lancet 349, 1161-1166.

Omotoso GO, Onanuga IO, Ibrahim RB. 2014. Histological effects of Permethrin Insecticide on the Testis of Adult Wistar Rats. Ibnosina Journal Medical Biomedical Sciences 125-129.

Paliwal A, Gurjar RK, Sharma HN. 2009. Analysis of liver enzymes in albino rat under stress of lambda-cyhalothrin and nuvan toxicity. BML 1(2), 70-73.

Patrick KC, Charles IA. 2014. Biochemical and histological changes in liver and kidney in male Wistar albino rats following exposure to Solignum: a permethrin-containing wood preservative. Journal Xenobiotics 4, 40-45.

Patrick-Iwuanyanwu KC, Udowelle NA, Okereke CJ. 2016. Testicular toxicity and sperm quality following exposure to solignum: A permethrin-containing wood preservative in adult male wistar rats. Journal Interdisciplinary Histopathology 4(1), 13-16.

Raj J, Mohineesh R, Dogra TD, Raina A. 2013. Acute oral toxicity and histopathological study of combination of endosulfan and cypermethrin in Wister rats. Toxicologicl International 20(1), 61-67.

Raj J, Mohineesh R, Dogra TD, Raina A. 2013. Acute oral toxicity and histopathological study of combination of endosulfan and cypermethrin in Wister rats. Toxicological International 20(1), 61-67.

Rehman H, Aziz A, Saggu S, Abbas ZK, Mohan A, Ansari A. 2014. Systemic review on pyrethroids toxicity with special reference to deltamethrin. Journal of Entomology and Zoological Studies 2(5), 01-06.

Sankar P, Telang. AGA. 2010. Manimaran. Curcumin protects against cypermethrin-induced genotoxicity in rats. Environment Toxicology Pharmacology, 30, 289-291.

Sarkar SN, Gupta PK. 1993. Fenvalerate-induced acute dermal toxicity in rats. Journal of Veterinary Physiology Allied Sciences 12, 17-22.

Saxena PN, Sharma DC. 2000. Effect of synthetic pyrethroid on behaviour pattern in Rattus norvegicus. Biological Sciences 70(1), 41-43.

Sayim F. 2007. Dimethoate induced biochemical and histopathological changes in the liver of rats. Expert Toxicology & Pathology 59, 237-243.

Sharma DC, Saxena PN, Singh VK, Sharma R. 2010. Assessment of DNA degradation in Lymphocytes of albino rat (Rattus norvegicus) under Lambda cyhalothrin stress. World Applied Sciences Journal 11(1), 24-28.

Sharma DC. 2004. Cytogenetic and biochemical alterations in blood of albino rat after synthetic pyrethroid intoxication. Ph. D. Thesis, Dr. B.R.A. University, Agra.

Singh VK. 2013. Synthetic pyrethroids: a brief review of effects on mammalian system toxicology. Indian Journal Biological Studies of Research 3(1), 1-27.

Soderlund DM, Clark JM, Sheets LP, Mullin LS, Piccirillo VJ, Sergeant D. 2002. Mechanism of pyrethroid neural toxicity implications for cumulative risk assessment. Toxicology 171, 53-59.

Tiwari VK, Suresh B, Pilo B. 2008. Evaluation of maternal toxicity in rats treated with deltamethrin 1% + triazophos 35% EC, ToxicolInt (Serial Online) 15, 127-131.

USEPA. 1999. Recognition and Management of Pesticide Poisoning 5th Ed.

Velmurugan B, Selvanayagama M, Cengiz Ei, Unlu E. 2007. Histopathology of lambda cyhalothrin on tissues (gill, kidney, liver and intestine) of Cirrhinus mrigala. Environment Toxicol Pharmacology 24, 286- 291.

Yuan C, Wang C, Gao SQ, Kong TT, Chen L, Li XF. 2010. Effects of permethrin, cypermethrin and 3-phenoxybenzoic acid on rat sperm motility in vitro evaluated with computer-assisted sperm analysis. ToxicolIn Vitro 24(2), 382-386.