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Study of the analgesic activity of the aqueous extract of Pseudocedrela kotschyi (Schweinf.) Harms (Meliaceae) trunk bark

Soro Tianga Yaya, Coulibaly Sirabana, Mian Jean Claude, Ehoussou N’douffou Célestin

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Int. J. Biosci.21(6), 366-377, December 2022

DOI: http://dx.doi.org/10.12692/ijb/21.6.366-377

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Abstract

Pseudocedrela kotschyi is a traditional medicine plant used by people in sub-Saharan regions to cure several diseases. The main objective of this study is to evaluate the analgesic activity of the aqueous extract of Pseudocedrela kotschyi trunk bark. Phytochemical screening revealed the presence of alkaloids, flavonoids, catechic tannins, saponosides, polyphenols, quinones, terpenoids, oses and holosides whereas coumarins and gallic tannins are absent. In the acute toxicity study, oral administration of the aqueous extract of Pseudocedrela kotschyi trunk bark did not cause any death among the rats. According to the organisation for economic cooperation and development (OECD) 423 classification system (OECD, 2001), the lethal dose 50 (LD50) of such an extract is therefore greater than 5000mg/kg body weight. On the other hand, this aqueous extract administered intraperitoneally provoked the death of certain mice. Thus an LD50 of 230.08mg/kg body weight was calculated. According to the classification of Diezi (1989), the aqueous extract of the trunk bark of this Pseudocedrela kotschyi is toxic by the intraperitoneal administration. Evaluation of the analgesic activity shows that the aqueous extract of this plant induces a decrease in the number of abdominal cramps in the writhing test and an inhibition of pain in the second phase of the formaldehyde test. On the other hand, the extract has no inhibiting effect on pain in the tail flick test and in the first phase of the formaldehyde test. These results justify the traditional use of Pseudocedrela kotschyi bark against pain.

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Study of the analgesic activity of the aqueous extract of Pseudocedrela kotschyi (Schweinf.) Harms (Meliaceae) trunk bark

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