Synthesis, analysis and biological studies of transition metal complexes of cefixime

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Research Paper 01/05/2019
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Synthesis, analysis and biological studies of transition metal complexes of cefixime

Yasir Mehmood, Sana Ghafoor, Humayun Riaz, Rana Khalid Mahmood, Abdulmannan Kashif, Abdulraheem Malik, Ayesha Tariq, Hammad Yousaf, Syed Atif Raza
Int. J. Biosci.14( 5), 63-76, May 2019.
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Cephalosporin is extensively used broad-spectrum antibiotic, containing β-lactam ring. However, due to overuse of this drug many bacteriological pathogens are now resistant. The study aim to prepare new derivatives of above drug, which will enhance biological activity against pathogens. In current study, cefixime was reacted with essential trace elements to synthesize respective metal complexes. It comprises formation of mixed ligand complexes of cefixime as primary ligand and glycine as secondary ligand with transition metals. The novel compounds were characterized physically like shape, color, melting point, solubility in different polar and non-polar solvents, pH and Rf value. Spectroscopic characterization like electronic spectra IR spectroscopy and antimicrobial screening against gram positive and gram negative bacterial strain. Biological screening of novel compounds was accomplished against diverse group of pathogens. Some of our novel compounds showed high efficacy against the pathogens as compare to parent composites.


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