Int. J. Biosci.14(5), 63-76, May 2019
Cephalosporin is extensively used broad-spectrum antibiotic, containing β-lactam ring. However, due to overuse of this drug many bacteriological pathogens are now resistant. The study aim to prepare new derivatives of above drug, which will enhance biological activity against pathogens. In current study, cefixime was reacted with essential trace elements to synthesize respective metal complexes. It comprises formation of mixed ligand complexes of cefixime as primary ligand and glycine as secondary ligand with transition metals. The novel compounds were characterized physically like shape, color, melting point, solubility in different polar and non-polar solvents, pH and Rf value. Spectroscopic characterization like electronic spectra IR spectroscopy and antimicrobial screening against gram positive and gram negative bacterial strain. Biological screening of novel compounds was accomplished against diverse group of pathogens. Some of our novel compounds showed high efficacy against the pathogens as compare to parent composites.
Aiyelabola TO, Isaac O, Olugbenga A. 2012. Structural and antimicrobial studies of coordination compounds of phenylalanine and glycine. International Journal of Chemistry 4, p 49.
ALI A. 2003. H2-Antagonist Cephalosporin Interactions. University of Karachi, Karachi.
Anacona JR, Estacio J. 2006. Synthesis and antibacterial activity of cefixime metal complexes. Transition metal chemistry 31, 227-231. http://dx.doi.org/10.1007/s11243-005-6360-9
Arayne MS, Sultana N, Khanum F, Ali MA. 2002. Antibacterial studies of cefixime copper, zinc and cadmium complexes. Pakistan journal of pharmaceutical sciences 15, 1-8.
Auda S, Mrestani Y, Fetouh M, Neubert R. 2008. Characterization and activity of cephalosporin metal complexes. Die Pharmazie-An International Journal of Pharmaceutical Sciences 63, 555-561.
Cleare M, Hydes P, Hepburn D, Malerbi B, Prestayko A, Crooke S, Carter S. 1980. Cisplatin, Current Status and New Developments. New York, 149-170.
El-Said A, Aly A, El-Meligy M, Ibrahim M. 2009. Mixed ligand zinc (II) and cadmium (II) complexes containing ceftriaxone or cephradine antibiotics and different donors. The Journal of the Argentine Chemical Society 97.
Fountain R, Russell A. 1969. Studies on the mode of action of some cephalosporin derivatives. Journal of Applied Bacteriology 32, 312-321. http://dx.doi.org/10.1111/j.13652672.1969.tb00978.x
Hayes RL. The medical use of gallium radionuclides: a brief history with some comments. Seminars in nuclear medicine, 1978. Elsevier, 183-191.
Ingber DE. 1998. The architecture of life. Scientific American 278, 48-57.
Kaushal R, Sheetal RK, Nehra K. Syntheses, Characterizations and Biological Screening of Titanium (IV) Complexes Derived from Antibiotic Drug (S).
Li J, Chen F, Cona MM, Feng Y, Himmelreich U, Oyen R, Verbruggen A, NI Y. 2012. A review on various targeted anticancer therapies. Targeted oncology 7, 69-85. http://dx.doi.org/10.1007/s11523-012-0212-2
Li NC, Doody BE, White JM. 1957. Some Metal Complexes of Glycine Peptides, Histidine and Related Substances1. Journal of the American Chemical Society 79, 5859-5863. http://dx.doi.org/10.1021/ja01579a006
Mahmoud WH, Mohamed GG, EL-Dessouky MM. 2015. Synthesis, structural characterization, in vitro antimicrobial and anticancer activity studies of ternary metal complexes containing glycine amino acid and the anti-inflammatory drug lornoxicam. Journal of Molecular Structure 1082, 12-22. http://dx.doi.org/10.1016/j.molstruc.2014.10.014
O’callaghan CH. 1975. Classification of cephalosporins by their antibacterial activity and pharmacokinetic properties. Journal of Antimicrobial Chemotherapy 1, 1-12. http://dx.doi.org/10.1093/jac/1.suppl_3.1
Patil SS, Thakur GA, Shaikh MM. 2012. Synthesis, spectral, thermal and antibacterial investigations of mixed ligand complexes of thorium (IV) derived from 8-hydroxyquinoline and some amino acids. Acta poloniae pharmaceutica 69, 1087-1093.
Pillai MS, Latha SP. 2012. Designing of some novel metallo antibiotics tuning biochemical behaviour towards therapeutics: Synthesis, characterisation and pharmacological studies of metal complexes of cefixime. Journal of Saudi Chemical Society. http://dx.doi.org/10.1016/j.jscs.2012.09.004
Reilly RM. 2007. The radiopharmaceutical science of monoclonal antibodies and peptides for imaging and targeted in situ radiotherapy of malignancies. Pharmaceutical Sciences Encyclopedia.
Sanoja W, Martínez JD, Araujo ML, Brito F, Hernández L, Del Carpio E, Lubes V. 2014. Stability constants of mixed ligand complexes of vanadium (III) with 8-hydroxyquinoline and the amino acids glycine, proline, α-alanine and β-alanine. Journal of Molecular Liquids, 197, 223-225. http://dx.doi.org/10.1016/j.molliq.2014.05.012
Soliman M, Hindy A, Mohamed G. 2014. Thermal decomposition and biological activity studies of some transition metal complexes derived from mixed ligands sparfloxacin and glycine. Journal of Thermal Analysis and Calorimetry 115, 987-1001. http://dx.doi.org/10.1007/s10973-013-3466-8
Sugiura Y, Takita T, Umezawa H. 1985. Bleomycin antibiotics: metal complexes and their biological action, Marcel Dekker: New York.
Vaidyanathan VG, Nair BU. 2003. Photooxidation of DNA by a cobalt (II) tridentate complex. Journal of inorganic biochemistry 94, 121-126. http://dx.doi.org/10.1016/S0162-0134(02)00620-7