Paper Details

Synthesis of chitosan based hydrogel nanocomposite  for controlled release of cisplatin drug

Hassan Fathinejad Jirandehi, Zahra Alimardan

DOI: http://dx.doi.org/10.12692/ijb/5.2.92-98

Int. J. Biosci. 5(2), 92-98. July, 2014. (PDF)

Abstract:

In this work, hydrogel nanocomposite was synthesized and studied targeted drug delivery by this hydrogel nanocomposite in pHs 1 to 6 and 7.4. The chitosan based hydrogel nanocomposite was synthesized via bonded acetaldehyde monomer on chitosan in presence MMT- Na+nanoclay. The superabsorbent nanocomposite structure was confirmed by FT-IR spectroscopy, SEM and XRD tests. The swelling behavior of superabsorbent nanocomposite examined in solutions with pH values 1 to 12. Then, cisplatin drug loaded in hydrogel nanocomposit and the amount of release drug was investigated in buffer solution with pH=7.4 via UV/Vis spectrophotometer.