The anti-inflammatory effect of acute exercise in asthma patients
Paper Details
The anti-inflammatory effect of acute exercise in asthma patients
Abstract
To investigate serum adiponectin response to acute cycling exercise and to determine the relationship between Changes in its levels with changes in respiratory function by exercise test. Venous blood samples and spirometry test were performed before and after a single bout l erogometer cycling exercise in order to measuring serum adiponectin, FEV1 and FVC in ninety middle-aged men (35. ±6 years mean ± standard deviation) with moderate asthma diagnosis that participated in this study by accessible sampling. Pre- to post training changes were determined by two-tailed t tests. The bivariate associations between changes in adiponectin concentrations with respiratory function were examined with the Pearson rank correlation analysis. Serum adiponectin was significantly increased in response to cycling exercise when compared with pretest (P < 0.05). FEV1 and FVC were also increased following by exercise test. After exercise test, serum adiponectin was positively correlated with FEVI (r= 0.83, p=0.000). These data suggest that exercise even for one session may be decrease systemic inflammation.
Cromwell O, Hamid Q, Corrigan CJ, Barkans J, Meng Q, Collins PD. 1992. Expression and generation of interleukin-8, IL-6 and granulocytemacrophage colony-stimulating factor by bronchial epithelial cells and enhancement by IL-1 beta and tumour necrosis factor-alpha. Immunology 77(3), 330-337.
Deetz DC, Jagielo PJ, Quinn TJ, Thorne PS, Bleuer SA, Schwartz DA. 1997. The kinetics of grain dust–induced inflammation of the lower respiratory tract. Am J Respir Crit Care Med 155, 254-259.
Georas SN, Guo J, De Fanis U, Casolaro V. 2005. T-helper cell type-2 regulation in allergic disease. Eur Respir J 26(6), 1119-1137.
Havel PJ. 2004. Update on adipocyte hormones. Regulation of energy balance and carbohydrate/lipid metabolism. Diabetes 53, 143-151.
Huang H, Iida KT, Sone H, Ajisaka R. 2005. The regulation of adiponectin receptors expression by acute exercise in mice. Exp Clin Endocrinol Diabetes 115(7), 417-22.
Impson KA, Fiatarone MA. 2008. Effects of exercise on adiponectin: a systematic review. Obesity 16(2), 241–56.
Jamurtas AZ, Theocharis V, Koukoulis G. 2006. The effects of acute exercise on serum adiponectin and resistin levels and their relation to insulin sensitivity in overweight males. Eur J Appl Physiol 97, 122–6.
Ju¨rima¨e J, Purge P, Ju¨rima¨e T. 2005. Adiponectin is altered after maximal exercise in highly trained male rowers. Eur J Appl Physiol 93, 502–5.
Kershaw EE, Flier JS. 2004. Adipose tissueas an endocrine organ. J Clin Endocrinol Metab 89, 2548-2556.
King C, Brennan S, Thompson PJ, Stewart GA. 1998. Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium. J Immunol 161(7), 3645-3651.
Kraemer RR, Aboudehen KS, Carruth AK. 2003. Adiponectin responses to continuous and progressively intense intermittent exercise. Med Sci Sports Exerc 35, 1320–5.
Mullis R, Campbell IT, Wearden AJ, Morriss RK, Pearson DJ. 1999. Prediction of peak oxygen uptake in chronic fatigue syndrome. British Journal of Sports Medicine 33(5), 352-6.
Nawrocki AR, Scherer PE. 2004. The delicate balance between fat and muscle: adipokines in metabolic disease andmusculoskeletal inflammation. Curr Opin Pharmacol 4, 281-289.
Neveu WA, Allard JL, Raymond DM, Bourassa LM, Burns SM, Bunn JY. 2010. Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function. Respir Res 11, 28.
Ouchi N, Kihara S, Funahashi T, Matsuzawa Y, Walsh K. 2003. Obesity, adiponectin and vascular inflammatory disease. Curr Opin Lipidol 14, 561-6.
Settin A, Zedan M, Farag M, Ezz El Regal M, Osman E. 2008. Gene polymorphisms of IL-6(-174) G/C and IL-1Ra VNTR in asthmatic children. Indian J Pediatr 75(10), 1019-23.
Shibata R, Ouchi N, Ito M, Kihara S, Shiojima I, Pimentel DRl. 2004. Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med 10, 1384-1389.
Shimada K, Miyazaki T, Daida H. 2004. Adiponectin and atherosclerotic disease. Clin Chim Acta 344, 1-12.
Shin JH, Kim JH, Lee WY, Shim JY. 2008. The Expression of Adiponectin Receptors and the Effects of Adiponectin and Leptin on Airway Smooth Muscle Cells. Yonsei Med J 49(5), 804-10.
Shore SA, Fredberg JJ. 2006. Obesity, smooth muscle, and airway hyperresponsiveness. J Allergy Clin Immunol 115, 925-7.
Shore SA, Johnston RA. 2006. Obesity and asthma. Pharmacol Ther 110, 83–102.
Shore SA, Terry RD, Flynt L. 2006. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 118, 389–95.
Shore SA. 2006. Obesity and asthma: cause for concern. Curr Opin Pharmacol 6, 230–6.
Sood A, Cui X, Qualls C, Beckett WS, Gross MD, Steffes MW. 2008. Association between asthma and serum adiponectin concentration in women. Thorax 63(10), 877-82.
Takahashi K, Mizuarai S, Araki H. 2003. Adiposity elevates plasma MCP-1 levels leading to the increased CD11b-positive monocytes in mice. J Biol Chem 278, 46654–60.
Tang Z, Yuan L, Gu C, Liu Y, Zhu L. 2005. Effect of exercise on the expression of adiponectin mRNA and GLUT4 mRNA in type 2 diabetic rats. J Huazhong Univ Sci Technolog Med Sci. 25(2), 191-3, 201.
Varady KA, Tussing L, Bhutani, Braunschweig CL. 2009. Degree of weight loss required to improve adipokine concentrations and decrease fat cell size in severely obese women. Metabolism 58(8), 1096-101.
Eizadi Mojtaba, Kohandel Mahdi, kasbparast JR Mehdi, Sarshin Amir, 2011. The anti-inflammatory effect of acute exercise in asthma patients. Int. J. Biosci., 1(3), 100-106.
Copyright © 2011 by the Authors. This article is an open access article and distributed under the terms and conditions of the Creative Commons Attribution 4.0 (CC BY 4.0) license.