Welcome to International Network for Natural Sciences | INNSpub

The effect of a cycling test on glucose and serum ghrelin in diabetic patients

Research Paper | November 1, 2012

| Download 5

Mehdi kasbparast JR, Hamid reza keshavarzi, Maryam Rostami, Saba Masoumi

Key Words:

J. Bio. Env. Sci.2( 11), 46-51, November 2012


JBES 2012 [Generate Certificate]


Previous studied have been shown higher serum ghrelin in diabetic patients than those without diabetic symptoms. In this study, we investigated serum ghrelin in response to an acute exercise test in adult men with type 2 diabetes. For this purpose, serum ghrelin, glucose and beta cell function were measured before and after a cycling test in nine males with type 2 diabetic (age 43 ± 7 yrs, body weight 91 ± 7 Kg). Student’s t-tests for paired samples were performed to determine significance of changes in variables by exercise test in studied patient. A p-value < 0.05 was considered to be statistically significant. Cycling exercise test resulted in significant decrease in ghrelin (0.012). Beta cell function was also increased after exercise test (0.038). Glucose concentration was decreased by exercise test in studied patients (0.008). Finally, it should be acknowledged that acute exercise with moderate intensity even for short-time can be decrease serum Ghrelin that is associated with an improvement in glucose in beta cell function in diabetic patients.


Copyright © 2012
By Authors and International Network for
Natural Sciences (INNSPUB)
This article is published under the terms of the Creative
Commons Attribution Liscense 4.0

The effect of a cycling test on glucose and serum ghrelin in diabetic patients

Ariga H, Imai K, Chen C, Mantyh C, Pappas TN, Takahashi T. 2008. Does ghrelin explain accelerated gastric emptying in the early stages of diabetes mellitus? Am J Physiol Regul Integr Comp Physiol 294(6), 1807-12.

Bergman R. Banting Lecture. 2006. Orchestration of glucose homeostasis: from a small acorn to the California Oak. Diabetes 56, 1489– 1500.

Broglio F, Arvat E, Benso A, Gottero C, Muccioli G, Papotti M, van der Lely AJ, Deghenghi R, Ghigo E. 2001. Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J Clin Endocrinol Metab 86, 5083–5086.

Broglio F, Gianotti L, Destefanis S, Fassino S, Abbate Daga G, Mondelli V. 2004. The endocrine response to acute ghrelin administration is blunted in patients with anorexia nervosa, a ghrelin hypersecretory state. Clin Endocrinol (Oxf) 60(5), 592-599.

Dezaki K, Sone H, Koizumi M, Nakata M, Kakei M, Nagai H, Hosoda H. 2006. Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance. Diabetes 55(12), 3486–3493.

Eizadi M, Khorshidi D, Dooaly H, Samarikhalaj H. 2011. Effects of exercise on glycemic control and insulin action in type II diabetes mellitus. International Journal of Biosciences 1(6), 147-154.

Ferrannini E, Gastaldelli A, Miayzaki Y, Matsuda M, Pettiti M, Natali A, Mari A, DeFronzo R. 2003. Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance. Diabetologia 46, 1211–1219.

Harsch IA, Koebnick C, Tasi AM, Hahn EG, Konturek PC. 2009. Ghrelin and Obestatin Levels in Type 2 Diabetic Patients With and Without Delayed Gastric Emptying. Dig Dis Sci 54(10), 2161-6.

Harsch IA, Koebnick C, Tasi AM, Hahn EG, Konturek PC. 2009. Ghrelin and Obestatin Levels in Type 2 Diabetic Patients With and Without Delayed Gastric Emptying. Dig Dis Sci. 54(10), 2161-6.

Kahn BB. 1998. Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance. Cell 92(5), 593–596.

Kahn S, Hull R, Utzschneider K. 2006. Mechanisms linking obesity to insulin resistance and to type 2 diabetes. Nature 444, 840-46.

Kelishadi R, Hashemipour M, Mohammadifard N, Alikhassy H, Adeli K. 2008. Short- and long-term relationships of serum ghrelin with changes in body composition and the metabolic syndrome in prepubescent obese children following two different weight loss programs. Clin Endocrinol (Oxf). [Epub ahead of print].

Knowler WC, Barrett-Connor E, Fowler SE. 2002. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346. 393–403.

Manson JE, Nathan DM, Krolewski AS, Stampfer MJ, Willett WC, and Hennekens CH. 1992. A prospective study of exercise and incidence of diabetes among United States male physicians. JAMA 268, 63–67.

Manson JE, Rimm EB, Stampfer MJ, Colditz GA, Willett WC, Krolewski AS, Rosner B, Hennekens CH, and Speizer FE. 1991. Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet 338, 774–7781.

Mullis R, Campbell IT, Wearden AJ, Morriss RK, Pearson DJ. 1999. Prediction of peak oxygen uptake in chronic fatigue syndrome. British Journal of Sports Medicine 33(5), 352-6.

O’Gorman DJ, Karlsson HK, McQuaid S. 2006. Exercise training increases insulin-stimulated glucose disposal and GLUT 4 (SLC2A4) protein content in patients with type 2 diabetes. Diabetologia 49, 2983–2992.

Pulkkinen L, Ukkola O, Kolehmainen M, Uusitupa M. 2010. Ghrelin in Diabetes and Metabolic Syndrome. Int J Pept. 3, 1-11.

Salehi A, Dornonville de la Cour C, Hakanson R, Lundquist I. 2004. Effects of ghrelin on insulin and glucagon secretion: a study of isolated pancreatic islets and intact mice. Regul Pept 118(3), 143–150.

Sun Y, Asnicar M, Saha PK, Chan L, Smith RG. 2006. Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab 3, 379–386.

Sun Y, Asnicar M, Smith RG. 2007. Central and peripheral roles of ghrelin on glucose homeostasis. Neuroendocrinology 86, 215–228.

Tuomilehto  J,    Lindstrom   J,   Eriksson   JG. 2001. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344, 1343–1350.

Ueno H, Shiiya T, Mizuta M, Mondal SM, Nakazato M. 2007. Plasma ghrelin concentrations in different clinical stages of diabetic complications and glycemic control in Japanese diabetics. Endocr J 54(6), 895-902.

Ukkola O, Kunnari A, Jokela M, Päivänsalo M, Kesäniemi YA. 2009. Ghrelin and metabolic disorders. Current Protein and Peptide Science 10 (1), 2–7.

Yada T, Dezaki K, Sone H, Koizumi M, Damdindorj B, Nakata M, Kakei M. 2008. Ghrelin regulates insulin release and glycemia: physiological role and therapeutic potential. Curr Diabetes Rev 4(1), 18-23.