The effect of nickel sulphate on bone composition in mice

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Research Paper 01/01/2019
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The effect of nickel sulphate on bone composition in mice

Khalid H. Gathwan, Ahmed Anwar Albir
Int. J. Biosci.14( 1), 183-185, January 2019.
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To find the effect of Nickel sulphate of the bone of mice.In this study the animals were divided into control and three experimental groups I, II and III according to the dose of nickel sulphate (NiSO4) administered orally to them i.e. 5.1, 11.7 and 24.2 mg/kg body weight, respectively. The femur bones were obtained by sacrificing the animals three weeks after weaning them once a week. The percentage loss between the wet weight and dry weight of femur in experimental groups I, II and III, the percentage loss was 31.6+1.6, 34.2+1.9 and 36.8+2.6 respectively, while in control animals was found to be 29.5+1.5. In the three experimental groups the percentage loss between the wet weight in wet water and dry weight in wet water was in the three 38.6+1.7, 41.5+2.8 and 49.1+2.9 respectively in the three experimental groups and 33.1+2.4 in the control group. Results indicates that there was a low deposition of bone mass (10-16%) due to the effect of nickel sulphate.


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