The effect of regular exercise on insulin action in sedentary postmenopausal women

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Research Paper 01/12/2014
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The effect of regular exercise on insulin action in sedentary postmenopausal women

Masomeh Sarmadiyan, Davood Khorshidi, Mohammad Karimi
J. Bio. Env. Sci.5( 6), 173-178, December 2014.
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Abstract

The purpose of the present study was to investigate the influence of a ten-week of exercise training on insulin, glucose and insulin resistance in healthy sedentary postmenopausal women. Twenty four postmenopausal women (aged 54.6±3.9 years) voluntarily participated in the study and randomly assigned into training (n=14) and control (n=10) groups. Subjects of training group were performed 10 weeks of exercise training including aerobic exercise (two sessions per week with 65-75 % MHR) and resistance exercise (two sessions per week with 55-65 % 1RM). Fasting blood glucose, fasting serum insulin measured at baseline and after training program. Insulin resistance calculated using glucose and insulin values. Data were analyzed using analysis of covariance test. There were no significant differences in fasting blood glucose, fasting serum insulin and insulin resistance between training and control groups after 10 weeks (P>0.05). In conclusion it seems that ten weeks of exercise training program has no effect on insulin action in healthy sedentary postmenopausal women.

VIEWS 1

Behboudi L, Azarbayjani M, Aghaalinejad H, Salavati M. 2011. Effects of aerobic exercise and whole body vibration on glycaemia control in type 2diabetic Male. Asian Journal of Sport Medicine 2(2), 83-90.

Bordenave S, Brandon F, Manetto J, FedouC, Mercier J, Brun JF. 2008. Effects of acute exercise on insulin sensitivity, glucose effectiveness and disposition index in type 2 diabetic patients. Diabetes and Metabolism 34(3), 250-7. http://dx.doi.org/10.1016/j.diabet.2007.12.008

Broom DR, Stensel DJ, Bishop N, Burns SF, Miyashita M. 2007. Exercise-induced suppression of acylated ghrelin in humans. Journal of applied physiology 102(6), 2165-71. http://dx.doi.org/10.1152/japplphysiol.00759.2006

Cartee GD, Young DA, Sleeper MD, Zierath J, Wallberg-Henrikssn H, Holloszy JO. 1989. Prolonged increase in insulin-stimulated glucose transport in muscle after exercise. The American journal of physiolgy 256, 494-9.

Coon PJ, Rogus EM, Glodberg AP. 1992.Time course  of  plasma  free  fatty  acid  concentration  in response  to  insulin:  effect  of  obesity  and  physical fitness. Metabolism: clinical and experimental 41(7), 711-6. http://dx.doi.org/10.1016/0026-0495(92)90309-X

Fairey AS, Courneya KS, Field CJ, Bell GJ,Jones LW, Mackey JR. 2003. Effects of Exercise Training on Fasting Insulin, Insulin Resistance, Insulin-like Growth Factor Binding Proteins in Postmenopausal Breast Cancer Survivors: A Randomized Controlled Trial. Cancer Epidemiology, Biomarkers and Prevention 12(8), 721-727.

Frank LL, Sorensen BE, Yasui Y, Tworoger SS, Schwartz RS, Ulrich CM, Irwin ML, Rudolph RE, Rajan KB, Stanczyk F, Bowen D, Weigle DS, Potter JD, McTiernan A. 2005. Effects of exercise on metabolic risk variables in overweight postmenopausal women: a randomized clinical trial. Obesity research 13(3), 615-25. http://dx.doi.org/10.1038/oby.2005.66

Friedenreich CM, Neilson HK, Woolcott CG, McTiernan A, Wang Q, Ballard-Barbash R, Jones CA, Stanczyk FZ, Brant RF, Yasui Y, Irwin ML, Campbell KL, McNeely ML, Karvinen KH, Courneya KS. 2011. Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal women. Endocrine related cancer 18(3), 357-69. http://dx.doi.org/10.1530/ERC-10-0303

Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Rohan TE, Manson JE, Li J, Ho GY, Xue X, Anderson GL, Kaplan RC, Harris TG, Howard BV, Wylie-Rosett J, Burk RD, Strickler HD. 2009. Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women. Journal of the National Cancer Institute 101(1), 48–60. http://dx.doi.org/10.1093/jnci/djn415

Holten MK, Zacho M, Gaster M, Juel C, Wojtaszewski JF, Dela F. 2004. Strength training increase  insulin-mediated  glucose  uptake,  GLUT-4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes. Diabetes 53(2), 294-305. http://dx.doi.org/10.2337/diabetes.53.2.294

Kern M, Wells JA, Stephens JM, Elton CW, Friedman JE, Tapscott EB, Pekala PH, Dohm GL. 1990. Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level. Biochemical Journal 270(2), 397-400.

Kim ES, Im JA, Kim KC, Park JH, Suh SH, Kang ES, Kim SH, Jekal Y, Lee CW, Yoon YJ, Lee HC, and Jeon JY. 2007. Improved Insulin Sensitivity and Adiponectin Level after Exercise Training in Obese Korean Youth. Obesity; 15, 3023-3030. http://dx.doi.org/10.1038/oby.2007.360

Marliss EB, Vranic M. 2002. Intense exercise has unique effects on both insulin release and its roles in glucoregulation: implications for diabetes. Diabetes 51 Suppl 1, 271–83. http://dx.doi.org/10.2337/diabetes.51.2007.S271

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. 1985. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7), 412-419. http://dx.doi.org/10.1007/BF00280883

McBride A, Hardie DG. 2009. AMP-activated protein kinase-a sensor of glycogen as well as AMP and ATP? Acta Physiolgica (oxford, England) 196(1), 99-133.

Nuri R, Kordi MR, Moghaddasi M, Rahnama N, Damirchi A, Rahmani-Nia F, Emami H. 2012. Effect of combination exercise training on metabolic syndrome parameters in postmenopausal women with breast cancer. Journal of cancer research and therapeutics 8(2), 238-42. http://dx.doi.org/10.4103/0973-1482.98977

Poehlman ET, Rosen CJ, Copeland KC. 1994. The influence of endurance training on insulin-like growth factor-1 in older individuals. Metabolism: clinical and experimental 43(11),1401-5. http://dx.doi.org/10.1016/0026-0495(94)90035-3

Praet SFE, Loon LJC. 2009. Exercise therapy in type 2 diabetes. Acta diabetologia 46(4), 263-78. http://dx.doi.org/10.1007/s00592-009-0129-0

Sillanpää E, Laaksonen DE, Häkkinen A, Karavirta L, Jensen B, Kraemer WJ, Nyman K, and Häkkinen K. 2009. Body composition, fitness, and metabolic health during strength and endurance training and their combination in middle-aged and older women. European journal of applied physiology 106(2), 285-296. http://dx.doi.org/10.1007/s00421-009-1013-x

Sudhaa SH, Rupali B, Vishal R, Tandon, Annil Mahajan. 2008. Postmenopausal obesity. Journal of Medical Education and Research 10(3), 105-6.

Zou CH, Shao J. 2008. Role of adiposytokine in obesity associated insulin resistance. Journal of nutritional Biochemistry 19(5), 277 – 286. http://dx.doi.org/10.1016/j.jnutbio.2007.06.006