The effect of resistance training on level of Leptin hormone in overweight females

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Research Paper 01/05/2014
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The effect of resistance training on level of Leptin hormone in overweight females

Kamyabnia Masoomeh, Shakeri Nader, Bakhshi Somayeh, Soheily Behzad
J. Bio. Env. Sci.4( 5), 366-372, May 2014.
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Obesity is associated with adverse changes in metabolic and cardiovascular risk factors, including high blood pressure, dyslipidemia, and insulin resistance, thereby leading to an increased risk of morbidity and mortality from cardiovascular disease and type 2 diabetes. Leptin had been noted to regulate energy balance and metabolism and thus to influence body weight. The present study is to determine the effect of resistance training on leptin in overweight females. Twenty overweight females subject (BMI ≥ 25) were randomly assigned to two groups (resistance training and control). The experimental training programs were performed three days a week for 12 weeks at a definite intensity and distance. Before and after 12 weeks intervention, Leptin, weight and body composition was measured for all subjects. Using independent T-test, the results showed that resistance training had significant effect on leptin, body weight and fat percentage (p ≤ 0.05). Our study finding demonstrated that resistance training leads to significant decrease of leptin levels.


Aminian-Razavi T, Gaeni A, Ravasi AA, Daryanosh F. 2007. The Effect of Two Methods of Alternative and Continuative Exercise on Changing Leptin in Non-Athlete Students of Tehran University. Harakat 31, 57- 69.

Ara J, Perez-Gomez G, Vicente-Rodriguez J, Chavarren C, Doradoand J. 2006. serum free testosterone, leptin and soluble leptin receptor changes in a 6-week strength-training programme. British Journal of Nutrition 96, 1053-59.

Benatti FB, Junior AH. 2007. Leptin and endurance exercise: implications of adiposity and insulin. Brazilian Journal of Sports Medicine 13 (4), 239E- 244E.

Fatouros IG, Tournis S, Leontsini D, Jamurtasn AZ, Sxina M, Thomakos P, et al. 2005. Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related”. Journal of Clinical Endocrinology & Metabolism 90, 5970-77.

Gil-Campos M, Aguilera C, Can RG. 2006. A Ghrelin: a hormone regulating food intake and energy homeostasis. British Journal of Nutrition 96, 201–226.

Gomez-Merino D, Chennaoui M, Drogou C, Bonneau D, Guezennec CY. 2002. Decrease in serum leptin after prolonged physical activity in men. Medicine and Science in Sports and Exercise 34(10), 1594-1599.

Haghighi AH, Hamedinia MR. 2008. The effect of 13 aerobic training on leptin obese men. Olampic 1(41), 89- 97.

Hamedinia MR, Porjahed J, Sardar MA, Haghighi AH. 2008. The effect of primary swimming training on leptin serum and related hormones in obese children and adolescents. Human Movement Science 2, 87- 96.

Hayase H, Nomura S, Abe T, Izawa T. 2002. Relation between fat distributions and several plasma adipocytokines alter exercise training in premenopausal and postmenopausal women. Journal of Physiological Anthropology and Applied Human Science 21(2), 105-113.

Houmard JA, Cox JH, Paul S. MacLean PS, Barakat HA. 2000. Effect of short-term  exercise training  on  leptin  and  insulin  action.  Metabolism 49(7), 858– 861.

Hsu Y, Wang P. 2007. Change of active ghrelin, leptin and female endocrine profiles at late follicular phase during 1 month endurance training in the chinese population. Biology of Reproduction 77, 104–104.

Imai T, Aizawa K, Hyun M, Iida K, Mural F, Kono I, et al. 2009. Acute effects of resistance exercise on adiponectin and leptin. Sports Medicine 58(2), 239- 246.

Inui A. 2001. Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nature Reviews Neuroscience 2(8), 551-560.

Kalra SP, Bagnasco M, Otukonyong EE, Dube MG, and Kalra PS. 2003. Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity. Regulatory Peptides 111(13), 1-11.

Kanaley J, Feicchia L, miller C, Ploutz synder L. 2001. “Resting leptin responses to acute and cronic resistance training in type 2 diabetic males and females”. International Journal of obesity 25, 1474-80.

Karen JA, Lorentzen C, Anderssen SA, Birkeland KI, Holme I, Lund-Larsen PG, et al. 2003. Promoting physical activity in a multi-ethnic district – methods and baseline results of a pseudo-experimental intervention study. European Journal of Cardiovascular  Prevention  &  Rehabilitation  10(5), 387-396.

Kojima M, Kangawa K. 2005. ghrelin: Structure and function. Physiological Reviews 85(2), 495-522.

Koutsari C, Karpe F, Humphreys S, Frayn K, Hardman A. 2003. Plasma leptin is influenced by diet composition and exercise. International Journal of Obesity 27, 901- 906.

Kraemer R, Chu H, Castracane V. 2002a. Leptin and exercise. Experimental Biology and Medicine 227(9), 701–708.

Kraemer W, Ratamess N, French D. 2002b. Resistance training for health and performance. Current Sports Medicine Reports 1, 165- 171.

Mager U. 2008. The role of ghrelin in obesity and insulin resistance. Kuopio University publications D. Medical Sciences 428, 123 p.

Ning Y, Williams M, Butler C, Muy-Rivera M, Frederick I, Sorensen T. 2005. Maternal recreational physical activity is associated with plasma leptin concentrations in early pregnancy. Human Reproduction 20(2), 382-389.

Ryan AS, Pratley RE, Goldberg AP. 2000. Changes  in  plasma  leptin  and  insulin  action  with resistive training in postmenopausal females. International journal of obesity and related metabolic disorders 24, 27–32.

Tsao TH, Hsu CH, Yang CB and Liou TL. 2009. The effect of exercise intensity on serum leptin and C reactive protein levels. Journal of Exercise Science and Fitness 7 (2), 98– 103.

Unal M, Unal DO, Baltaci AK, Mogulkoc. 2005. Investigation of serum leptin levels and VO2max value in trained young male athletes and healthy males.  Acta  Physiology  Hungary  92(2), 173-  179.

Unal M, Unal DO, Baltaci AK, Mogulkoc R, Kayserilioglu A2005b.  Investigation  of  serum leptin levels in professional male football players and healthy  sedentary  males.  Neuro  Endocrinology Letters 26(2), 148-151.

World Health Organisation. 2004. The  Global Burden of Disease update.

Zigman  JM,  Elmquist  JK.  2003.  Minireview: From anorexia to obesitythe yin and yang of body weight control. Endocrinology 144(9), 3749- 3756.